Entity Details

Primary name PAK3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75914
EntryNamePAK3_HUMAN
FullNameSerine/threonine-protein kinase PAK 3
TaxID9606
Evidenceevidence at protein level
Length559
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesPAK3

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007409 axonogenesis
GO:0010763 positive regulation of fibroblast migration
GO:0014069 postsynaptic density
GO:0016358 dendrite development
GO:0017124 SH3 domain binding
GO:0030833 regulation of actin filament polymerization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031267 small GTPase binding
GO:0031295 T cell costimulation
GO:0032147 activation of protein kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0046872 metal ion binding
GO:0048013 ephrin receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0050808 synapse organization
GO:0050852 T cell receptor signaling pathway
GO:0060997 dendritic spine morphogenesis
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0071407 cellular response to organic cyclic compound
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033923 p21 activated kinase binding domainDomainDomain
IPR035063 p21-activated kinase 3, catalytic domainDomainDomain
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
300558 OMIMMental retardation, X-linked 30 (MRX30)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule