Entity Details

Primary name PARN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95453
EntryNamePARN_HUMAN
FullNamePoly(A)-specific ribonuclease PARN
TaxID9606
Evidenceevidence at protein level
Length639
SequenceStatuscomplete
DateCreated2005-03-01
DateModified2021-06-02

Ontological Relatives

GenesPARN

GO terms

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GOName
GO:0000175 3'-5'-exoribonuclease activity
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000495 box H/ACA RNA 3'-end processing
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004518 nuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0007292 female gamete generation
GO:0009451 RNA modification
GO:0010587 miRNA catabolic process
GO:0016607 nuclear speck
GO:0019901 protein kinase binding
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0043169 cation binding
GO:0043488 regulation of mRNA stability
GO:0046872 metal ion binding
GO:0051973 positive regulation of telomerase activity
GO:0070034 telomerase RNA binding
GO:0071051 polyadenylation-dependent snoRNA 3'-end processing
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:0090669 telomerase RNA stabilization
GO:0110008 ncRNA deadenylation
GO:1904872 regulation of telomerase RNA localization to Cajal body

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001374 R3H domainDomainDomain
IPR006941 Ribonuclease CAF1FamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR014789 Poly(A)-specific ribonuclease, RNA-bindingDomainDomain
IPR034042 PARN, R3H domainDomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR036867 R3H domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616353 OMIMDyskeratosis congenita, autosomal recessive, 6 (DKCB6)A form of dyskeratosis congenita, a rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. The disease is caused by variants affecting the gene represented in this entry.
616371 OMIMPulmonary fibrosis, and/or bone marrow failure, telomere-related, 4 (PFBMFT4)A disease associated with shortened telomeres. Pulmonary fibrosis is the most common manifestation. Other manifestations include aplastic anemia due to bone marrow failure, hepatic fibrosis, and increased cancer risk, particularly myelodysplastic syndrome and acute myeloid leukemia. Phenotype, age at onset, and severity are determined by telomere length. The disease is caused by variants affecting the gene represented in this entry.

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
PARN_HUMANMPH6_HUMANHPRD, IntAct15231747 details
PARN_HUMANSPC1L_HUMANBioGRID, HPRD, IntAct15231747 details
PARN_HUMANBARD1_HUMANBioGRID, MINT20379136 details
PARN_HUMANNCBP1_HUMANMINT20379136 details
PARN_HUMANMAPK2_HUMANBioGRID20932473 details
PARN_HUMANPALS2_HUMANBioGRID15231747 details
PARN_HUMANSUMO2_HUMANBioGRID19394292 details
PARN_HUMANCSTF2_HUMANBioGRID, MINT20379136 details
PARN_HUMANPABP1_HUMANIntAct17595167 details
PARN_HUMANZCCHV_HUMANDIP21876179 details
PARN_HUMANFUBP2_HUMANBioGRID, HPRD15175153 details
PARN_HUMANRENT1_HUMANBioGRID14527413 details
PARN_HUMANRENT2_HUMANBioGRID14527413 details
PARN_HUMANREN3A_HUMANBioGRID14527413 details
PARN_HUMANCSTF1_HUMANBioGRID20379136 details
PARN_HUMANPARN_HUMANBioGRID20379136 details
PARN_HUMANNXF1_HUMANBioGRID29395067 details
PARN_HUMANFANCI_HUMANBioGRID29395067 details
PARN_HUMANJHD2C_HUMANBioGRID29395067 details
PARN_HUMANGWL_HUMANBioGRID29395067 details
PARN_HUMANNCOR1_HUMANBioGRID29395067 details
PARN_HUMANRS15A_HUMANBioGRID29395067 details
PARN_HUMANRRP12_HUMANBioGRID29395067 details
PARN_HUMANSIR1_HUMANBioGRID29395067 details
PARN_HUMANUT14A_HUMANBioGRID29395067 details
PARN_HUMANYETS2_HUMANBioGRID29395067 details
PARN_HUMANSMG7_HUMANBioGRID29395067 details
PARN_HUMANBCOR_HUMANBioGRID29395067 details
PARN_HUMANDACH1_HUMANBioGRID29395067 details
PARN_HUMANESS2_HUMANBioGRID29395067 details
PARN_HUMANZBT21_HUMANBioGRID29395067 details
PARN_HUMANZSC18_HUMANBioGRID29395067 details
PARN_HUMANCSTF3_HUMANBioGRID29395067 details
PARN_HUMANBRE1B_HUMANBioGRID29395067 details
PARN_HUMANF207A_HUMANBioGRID29395067 details
PARN_HUMANH31_HUMANBioGRID29395067 details
PARN_HUMANNCOR2_HUMANBioGRID29395067 details
PARN_HUMANNFIC_HUMANBioGRID29395067 details
PARN_HUMANRBM5_HUMANBioGRID29395067 details
PARN_HUMANNADAP_HUMANBioGRID29395067 details
PARN_HUMANTRPS1_HUMANBioGRID29395067 details
PARN_HUMANSHLD2_HUMANBioGRID30154076 details