Entity Details

Primary name ISK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00995
EntryNameISK1_HUMAN
FullNameSerine protease inhibitor Kazal-type 1
TaxID9606
Evidenceevidence at protein level
Length79
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesSPINK1

GO terms

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GOName
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0048240 sperm capacitation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0060046 regulation of acrosome reaction
GO:0070062 extracellular exosome
GO:0090281 negative regulation of calcium ion import
GO:1900004 negative regulation of serine-type endopeptidase activity
GO:2001256 regulation of store-operated calcium entry

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001239 Proteinase inhibitor I1, Kazal-type, metazoaFamilyFamily
IPR002350 Kazal domainDomainDomain
IPR036058 Kazal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
167800 OMIMPancreatitis, hereditary (PCTT)A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks. Disease susceptibility is associated with variants affecting the gene represented in this entry.
608189 OMIMTropical calcific pancreatitis (TCP)Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer. Disease susceptibility is associated with variants affecting the gene represented in this entry.