Entity Details

Primary name PDYN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01213
EntryNamePDYN_HUMAN
FullNameProenkephalin-B
TaxID9606
Evidenceevidence at protein level
Length254
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPDYN

GO terms

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GOName
GO:0001515 opioid peptide activity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007600 sensory perception
GO:0030425 dendrite
GO:0031628 opioid receptor binding
GO:0043025 neuronal cell body
GO:0043679 axon terminus

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000750 Proenkephalin BFamilyFamily
IPR006024 Opioid neuropeptide precursorFamilyFamily

Diseases

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Disease IDSourceNameDescription
610245 OMIMSpinocerebellar ataxia 23 (SCA23)Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an adult-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. The disease is caused by variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PDYN_HUMANA4_HUMANBioGRID21832049 details
PDYN_HUMANNRDC_HUMANHPRD12590613 details