Entity Details

Primary name INS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01308
EntryNameINS_HUMAN
FullNameInsulin
TaxID9606
Evidenceevidence at protein level
Length110
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesINS

GO terms

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GOName
GO:0005576 extracellular region
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006953 acute-phase response
GO:0008284 positive regulation of cell population proliferation
GO:0030133 transport vesicle
GO:0031954 positive regulation of protein autophosphorylation
GO:0042311 vasodilation
GO:0042593 glucose homeostasis
GO:0043410 positive regulation of MAPK cascade
GO:0045597 positive regulation of cell differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0045861 negative regulation of proteolysis
GO:0048167 regulation of synaptic plasticity
GO:0050709 negative regulation of protein secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0055089 fatty acid homeostasis
GO:0060267 positive regulation of respiratory burst
GO:0090336 positive regulation of brown fat cell differentiation
GO:1902952 positive regulation of dendritic spine maintenance
GO:1903076 regulation of protein localization to plasma membrane
GO:1903427 negative regulation of reactive oxygen species biosynthetic process
GO:1990535 neuron projection maintenance
GO:0000139 Golgi membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006521 regulation of cellular amino acid metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0008286 insulin receptor signaling pathway
GO:0010750 positive regulation of nitric oxide mediated signal transduction
GO:0022898 regulation of transmembrane transporter activity
GO:0030307 positive regulation of cell growth
GO:0031904 endosome lumen
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032880 regulation of protein localization
GO:0038060 nitric oxide-cGMP-mediated signaling pathway
GO:0042060 wound healing
GO:0045840 positive regulation of mitotic nuclear division
GO:0046631 alpha-beta T cell activation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0050890 cognition
GO:0050995 negative regulation of lipid catabolic process
GO:0051897 positive regulation of protein kinase B signaling
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000252 negative regulation of feeding behavior
GO:0005159 insulin-like growth factor receptor binding
GO:0005179 hormone activity
GO:0005615 extracellular space
GO:0006006 glucose metabolic process
GO:0032148 activation of protein kinase B activity
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0034774 secretory granule lumen
GO:0042177 negative regulation of protein catabolic process
GO:0045818 negative regulation of glycogen catabolic process
GO:0045821 positive regulation of glycolytic process
GO:0046326 positive regulation of glucose import
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0050708 regulation of protein secretion
GO:1990000 amyloid fibril formation
GO:0001819 positive regulation of cytokine production
GO:0002020 protease binding
GO:0002674 negative regulation of acute inflammatory response
GO:0005158 insulin receptor binding
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0010628 positive regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030335 positive regulation of cell migration
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0042802 identical protein binding
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045922 negative regulation of fatty acid metabolic process
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0090277 positive regulation of peptide hormone secretion
GO:1900182 positive regulation of protein localization to nucleus
GO:1900273 positive regulation of long-term synaptic potentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR004825 InsulinFamilyFamily
IPR016179 Insulin-likeDomainDomain
IPR022352 Insulin familyFamilyFamily
IPR022353 Insulin, conserved siteSiteConserved site
IPR036438 Insulin-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
125852 OMIMDiabetes mellitus, insulin-dependent, 2 (IDDM2)A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. The disease is caused by variants affecting the gene represented in this entry.
613370 OMIMMaturity-onset diabetes of the young 10 (MODY10)A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. The disease is caused by variants affecting the gene represented in this entry.
616214 OMIMHyperproinsulinemia (HPRI)An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material. The disease is caused by variants affecting the gene represented in this entry.
618858 OMIMDiabetes mellitus, permanent neonatal, 4 (PNDM4)A form of permanent neonatal diabetes mellitus, a type of diabetes characterized by onset of persistent hyperglycemia within the first six months of life. Initial clinical manifestations include intrauterine growth retardation, hyperglycemia, glycosuria, osmotic polyuria, severe dehydration, and failure to thrive. PNDM4 transmission pattern is consistent with autosomal dominant or autosomal recessive inheritance. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB01776 M-CresolDrugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
INS_HUMANINS_HUMANBioGRID, DIP, HPRD, MINT, UniProt10508408 12021212 17472440 20738396 22854022 23106816 23416304 23510797 32457219 8844841 details
INS_HUMANMK06_HUMANBioGRID, MINT21900206 details
INS_HUMANPGS2_HUMANmatrixdb24389353 details
INS_HUMANNT2NC_HUMANBioGRID, IntAct32296183 details
INS_HUMANATL4_HUMANBioGRID, IntAct32296183 details
INS_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
INS_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
INS_HUMANIDE_HUMANBioGRID, DIP, HPRD11145591 17051221 29273204 details
INS_HUMANINSR_HUMANDIP, HPRD23302862 2550426 29512653 details
INS_HUMANTXD17_HUMANBioGRID, HPRD14607844 details
INS_HUMANKMT2A_HUMANBioGRID14607844 details
INS_HUMANCCN3_HUMANBioGRID, HPRD10084601 details
INS_HUMANIBP7_HUMANBioGRID, HPRD9388210 details
INS_HUMANCRYAB_HUMANBioGRID17487982 details
INS_HUMANA4_HUMANBioGRID21832049 details
INS_HUMANHSPB1_HUMANBioGRID10383393 details
INS_HUMANITF2_HUMANBioGRID25416956 details
INS_HUMANRGS20_HUMANBioGRID25416956 details
INS_HUMANPTEN_HUMANBioGRID11439092 details
INS_HUMANHSP7C_HUMANBioGRID29764935 32457219 details
INS_HUMANHS71A_HUMANBioGRID29764935 details
INS_HUMANHS71B_HUMANBioGRID29764935 details
INS_HUMANKRA13_HUMANBioGRID32296183 details
INS_HUMANNT2NA_HUMANBioGRID32296183 details
INS_HUMANRB_HUMANBioGRID, HPRD10938588 7818556 details
INS_HUMANPRDX4_HUMANBioGRID32457219 details
INS_HUMANCATB_HUMANBioGRID, HPRD32457219 6351842 details
INS_HUMANBIP_HUMANBioGRID32457219 details
INS_HUMANMY18A_HUMANBioGRID32457219 details
INS_HUMANDJC10_HUMANBioGRID32457219 details
INS_HUMANENPL_HUMANBioGRID32457219 details
INS_HUMANLRP2_HUMANHPRD9773776 details
INS_HUMANDQB1_HUMANHPRD11376336 details
INS_HUMANSYTL4_HUMANHPRD10497219 details
INS_HUMANDQA2_HUMANHPRD11376336 details
INS_HUMANCBPE_HUMANHPRD10966857 7477119 details
INS_HUMANCATD_HUMANHPRD11779865 details
INS_HUMANCATE_HUMANHPRD195962 1959628 details
INS_HUMANHXK4_HUMANHPRD12101177 details
INS_HUMANIGF1R_HUMANHPRD1851182 details