Entity Details

Primary name ITB3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05106
EntryNameITB3_HUMAN
FullNameIntegrin beta-3
TaxID9606
Evidenceevidence at protein level
Length788
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesITGB3

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0001968 fibronectin binding
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0003756 protein disulfide isomerase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007596 blood coagulation
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010888 negative regulation of lipid storage
GO:0014909 smooth muscle cell migration
GO:0015026 coreceptor activity
GO:0016477 cell migration
GO:0019899 enzyme binding
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031092 platelet alpha granule membrane
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0031528 microvillus membrane
GO:0031589 cell-substrate adhesion
GO:0032147 activation of protein kinase activity
GO:0032369 negative regulation of lipid transport
GO:0032587 ruffle membrane
GO:0032880 regulation of protein localization
GO:0032991 protein-containing complex
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034683 integrin alphav-beta3 complex
GO:0035295 tube development
GO:0035866 alphav-beta3 integrin-PKCalpha complex
GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex
GO:0035868 alphav-beta3 integrin-HMGB1 complex
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042060 wound healing
GO:0042470 melanosome
GO:0042802 identical protein binding
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043235 receptor complex
GO:0043277 apoptotic cell clearance
GO:0045124 regulation of bone resorption
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0046718 viral entry into host cell
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048333 mesodermal cell differentiation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050748 negative regulation of lipoprotein metabolic process
GO:0050839 cell adhesion molecule binding
GO:0050840 extracellular matrix binding
GO:0050900 leukocyte migration
GO:0050919 negative chemotaxis
GO:0051611 regulation of serotonin uptake
GO:0060055 angiogenesis involved in wound healing
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0071062 alphav-beta3 integrin-vitronectin complex
GO:0098978 glutamatergic synapse
GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization
GO:1905598 negative regulation of low-density lipoprotein receptor activity

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR027068 Integrin beta-3 subunitFamilyFamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR040622 Integrin beta, epidermal growth factor-like domain 1DomainDomain

Diseases

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Disease IDSourceNameDescription
273800 OMIMGlanzmann thrombasthenia (GT)A common inherited disease of platelet aggregation. It is characterized by mucocutaneous bleeding of mild-to-moderate severity. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels, have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The disease is caused by variants affecting the gene represented in this entry.
187800 OMIMBleeding disorder, platelet-type 16 (BDPLT16)An autosomal dominant form of congenital macrothrombocytopenia associated with platelet anisocytosis. It is a disorder of platelet production. Affected individuals may have no or only mildly increased bleeding tendency. In vitro studies show mild platelet functional abnormalities. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00054 AbciximabDrugbankbiotech
DB00063 EptifibatideDrugbankbiotech
DB00098 Antithymocyte immunoglobulin (rabbit)Drugbankbiotech
DB00451 LevothyroxineDrugbanksmall molecule
DB00775 TirofibanDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB04863 LefradafibanDrugbanksmall molecule
DB05787 LM-609Drugbankbiotech
DB06472 FradafibanDrugbanksmall molecule
DB13949 Ferric cationDrugbanksmall molecule
DB14520 Tetraferric tricitrate decahydrateDrugbanksmall molecule
DB15598 Ferric maltolDrugbanksmall molecule

Interactions

71 interactions

InteractorPartnerSourcesPublicationsLink
ITB3_HUMANITAV_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT10891446 11546839 11884718 15299032 16099422 1694173 20639902 22178926 24658351 25792870 9686320 details
ITB3_HUMANEPS8_HUMANHPRD, MINT12606711 details
ITB3_HUMANRBGP1_HUMANMINT12606711 details
ITB3_HUMANANS1B_HUMANMINT12606711 details
ITB3_HUMANGULP1_HUMANMINT12606711 details
ITB3_HUMANRGS12_HUMANMINT12606711 details
ITB3_HUMANJIP1_HUMANMINT12606711 details
ITB3_HUMANTNS2_HUMANHPRD, MINT12606711 details
ITB3_HUMANITB3_HUMANDIP, HPRD, IntAct11606749 12606711 14681217 22178926 details
ITB3_HUMANITA2B_HUMANBioGRID, DIP, HPRD, IntAct, MINT10358085 10891446 11412103 11606749 1429573 14681217 15067009 15219201 15379538 17032655 18791937 19279667 19805198 22178926 25849143 30804189 9351872 details
ITB3_HUMANTLN1_HUMANBioGRID, HPRD, MINT10497223 11412103 11932255 12606711 16546176 19843520 details
ITB3_HUMANFINC_HUMANBioGRID, DIP, HPRD, IntAct11478883 1694173 24658351 24789099 details
ITB3_HUMANLYN_HUMANmbinfo14593208 details
ITB3_HUMANFIBG_HUMANBioGRID, HPRD, IntAct10747940 16877710 24789099 25398877 details
ITB3_HUMANX3CL1_HUMANIntAct23125415 24789099 details
ITB3_HUMANFLNA_HUMANBioGRID, DIP11807098 25849143 details
ITB3_HUMANFAK1_HUMANBioGRID11927607 19889638 9169439 details
ITB3_HUMANFLNB_HUMANBioGRID11807098 details
ITB3_HUMANCENPR_HUMANBioGRID, HPRD11864709 7593198 details
ITB3_HUMANTSP1_HUMANBioGRID, HPRD14963009 2478219 details
ITB3_HUMANFAK2_HUMANBioGRID, HPRD11683411 details
ITB3_HUMANPAXI_HUMANBioGRID11683411 details
ITB3_HUMANITA5_HUMANBioGRID, HPRD10358085 1694173 22470492 26344197 details
ITB3_HUMANPDIA1_HUMANBioGRID21670307 details
ITB3_HUMANPA24A_HUMANBioGRID18840708 details
ITB3_HUMANMK03_HUMANBioGRID23640055 details
ITB3_HUMANSHC1_HUMANBioGRID, HPRD10896934 10964917 19889638 details
ITB3_HUMANPA2GA_HUMANBioGRID18635536 details
ITB3_HUMANDOK1_HUMANBioGRID, HPRD12606711 19843520 details
ITB3_HUMANFIBA_HUMANBioGRID, HPRD11460491 9058485 details
ITB3_HUMANSRC_HUMANBioGRID, HPRD10896934 11723131 details
ITB3_HUMANAKT1_HUMANBioGRID, HPRD10896934 details
ITB3_HUMANPDK1_HUMANBioGRID10896934 details
ITB3_HUMANCDK1_HUMANBioGRID10896934 details
ITB3_HUMANFGFR1_HUMANBioGRID27371729 details
ITB3_HUMANA4_HUMANBioGRID27221710 details
ITB3_HUMANRASH_HUMANBioGRID30655611 details
ITB3_HUMANGRIA2_HUMANBioGRID22232691 details
ITB3_HUMANPTN1_HUMANMINT16115959 details
ITB3_HUMANPTN11_HUMANMINT12791772 details
ITB3_HUMANPTPRZ_HUMANBioGRID, I2D19141530 20639902 details
ITB3_HUMANILK_HUMANBioGRID, HPRD12372433 details
ITB3_HUMANPECA1_HUMANBioGRID, HPRD10982404 details
ITB3_HUMANPGFRB_HUMANBioGRID, HPRD10964931 details
ITB3_HUMANPGFRA_HUMANBioGRID, HPRD11953315 details
ITB3_HUMANCD36_HUMANBioGRID, HPRD11238109 details
ITB3_HUMANKSYK_HUMANBioGRID11042121 details
ITB3_HUMANEPHA2_HUMANBioGRID23874206 details
ITB3_HUMANVIME_HUMANBioGRID18840708 details
ITB3_HUMANKPCB_HUMANBioGRID18840708 details
ITB3_HUMANVGFR2_HUMANBioGRID, HPRD10022831 25644401 details
ITB3_HUMANPAK4_HUMANBioGRID23254288 details
ITB3_HUMANMMP2_HUMANBioGRID23254288 details
ITB3_HUMANITA4_HUMANBioGRID25792870 details
ITB3_HUMANITB1_HUMANBioGRID25792870 details
ITB3_HUMANCIB1_HUMANBioGRID24163826 details
ITB3_HUMANURP2_HUMANBioGRID25609252 details
ITB3_HUMANPTN_HUMANBioGRID19141530 details
ITB3_HUMANTGM2_HUMANHPRD10684262 details
ITB3_HUMANP2RY2_HUMANHPRD11331301 details
ITB3_HUMANDAB2_HUMANHPRD12606711 details
ITB3_HUMANDAB1_HUMANHPRD12606711 details
ITB3_HUMANNUMB_HUMANHPRD12606711 details
ITB3_HUMANPDPK1_HUMANHPRD10896934 details
ITB3_HUMANANGL3_HUMANHPRD11877390 details
ITB3_HUMANVTNC_HUMANHPRD16195248 details
ITB3_HUMANCAN1_HUMANHPRD7592818 details
ITB3_HUMANTHY1_HUMANHPRD15897908 details
ITB3_HUMANCO1A2_HUMANHPRD1693626 details
ITB3_HUMANNID1_HUMANHPRD8831898 9686320 details
ITB3_HUMANFBLN2_HUMANHPRD10848816 details