Entity Details

Primary name THA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10827
EntryNameTHA_HUMAN
FullNameThyroid hormone receptor alpha
TaxID9606
Evidenceevidence at protein level
Length490
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTHRA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0002154 thyroid hormone mediated signaling pathway
GO:0002155 regulation of thyroid hormone mediated signaling pathway
GO:0003700 DNA-binding transcription factor activity
GO:0004879 nuclear receptor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0007611 learning or memory
GO:0008016 regulation of heart contraction
GO:0008050 female courtship behavior
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0009409 response to cold
GO:0009755 hormone-mediated signaling pathway
GO:0017025 TBP-class protein binding
GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030878 thyroid gland development
GO:0031490 chromatin DNA binding
GO:0033032 regulation of myeloid cell apoptotic process
GO:0044877 protein-containing complex binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050994 regulation of lipid catabolic process
GO:0060509 type I pneumocyte differentiation
GO:0070324 thyroid hormone binding
GO:0120162 positive regulation of cold-induced thermogenesis
GO:2000143 negative regulation of DNA-templated transcription, initiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000536 Nuclear hormone receptor, ligand-binding domainDomainDomain
IPR001628 Zinc finger, nuclear hormone receptor-typeDomainDomain
IPR001723 Nuclear hormone receptorFamilyFamily
IPR001728 Thyroid hormone receptorFamilyFamily
IPR013088 Zinc finger, NHR/GATA-typeFamilyHomologous superfamily
IPR035500 Nuclear hormone receptor-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614450 OMIMHypothyroidism, congenital, non-goitrous, 6 (CHNG6)A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00279 LiothyronineDrugbanksmall molecule
DB00451 LevothyroxineDrugbanksmall molecule
DB00509 DextrothyroxineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01583 LiotrixDrugbanksmall molecule
DB03176 KB-141Drugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB05035 EprotiromeDrugbanksmall molecule
DB05235 NRP409Drugbanksmall molecule
DB09100 Thyroid, porcineDrugbankbiotech

Interactions

95 interactions

InteractorPartnerSourcesPublicationsLink
THA_HUMANNCOA6_HUMANBioGRID, HPRD, IntAct10567404 10681503 10847592 10866662 11158331 details
THA_HUMANCEP76_HUMANBioGRID, IntAct, MINT21516116 32296183 details
THA_HUMANCLIC1_HUMANBioGRID, IntAct21988832 details
THA_HUMANFOXJ1_HUMANBioGRID, IntAct21988832 details
THA_HUMANBUB3_HUMANBioGRID, IntAct21988832 details
THA_HUMANAMOT_HUMANBioGRID, IntAct23414517 details
THA_HUMANAKP13_HUMANBioGRID, HPRD, UniProt9627117 details
THA_HUMANMED1_HUMANBioGRID, HPRD, UniProt10037764 10733574 11117530 16799563 18391015 21868449 8710870 9653119 details
THA_HUMANTRXR1_HUMANBioGRID, IntAct15199063 details
THA_HUMANLMBL3_HUMANBioGRID, IntAct25416956 details
THA_HUMANAMOL2_HUMANBioGRID, IntAct25416956 32296183 details
THA_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
THA_HUMANSYAP1_HUMANBioGRID, IntAct32296183 details
THA_HUMANKAP1_HUMANBioGRID, IntAct32296183 details
THA_HUMANTACC1_HUMANBioGRID, IntAct32296183 details
THA_HUMANBY55_HUMANBioGRID, IntAct32296183 details
THA_HUMANZBTB3_HUMANIntAct20211142 details
THA_HUMANNRIP1_HUMANBioGRID, IntAct10379889 15130509 20211142 21868449 9626662 details
THA_HUMANTDG_HUMANBioGRID, HPRD12874288 details
THA_HUMANMEF2A_HUMANBioGRID, HPRD12371907 details
THA_HUMAN1433T_HUMANBioGRID11266503 details
THA_HUMANCENPR_HUMANBioGRID10490654 11713274 details
THA_HUMANPO2F1_HUMANBioGRID, HPRD10480874 details
THA_HUMANRT29_HUMANBioGRID10903152 details
THA_HUMANNR0B2_HUMANBioGRID8650544 details
THA_HUMANMED21_HUMANBioGRID, HPRD10198638 15249124 details
THA_HUMANTIF1A_HUMANBioGRID, HPRD31753913 9115274 details
THA_HUMANCSN2_HUMANBioGRID, HPRD10207062 10877839 details
THA_HUMANTRIPB_HUMANBioGRID9256431 details
THA_HUMANRXRA_HUMANBioGRID, HPRD11117530 1314167 1331778 15604093 19422879 details
THA_HUMANFUS_HUMANBioGRID, HPRD9440806 details
THA_HUMANHDAC3_HUMANBioGRID11889044 17242407 details
THA_HUMANNCOR1_HUMANBioGRID, HPRD11889044 15131262 15604093 17242407 7566114 9804773 9849963 details
THA_HUMANSUV91_HUMANBioGRID12138181 details
THA_HUMANNCOA1_HUMANBioGRID, HPRD10379889 11117530 11435616 15140878 15249124 9804773 9849963 details
THA_HUMANNCOA2_HUMANBioGRID11117530 11435616 details
THA_HUMANTAF11_HUMANBioGRID10744685 details
THA_HUMANGRIP1_HUMANBioGRID10379889 9849963 details
THA_HUMANNCOR2_HUMANBioGRID, HPRD16219912 17242407 7566127 9415406 details
THA_HUMANPRKDC_HUMANBioGRID17242407 details
THA_HUMANTBL1X_HUMANBioGRID17242407 details
THA_HUMANCUL1_HUMANBioGRID, HPRD15604093 details
THA_HUMANRGN_HUMANBioGRID, HPRD15604093 details
THA_HUMANSEPP1_HUMANBioGRID15604093 details
THA_HUMANCDK7_HUMANBioGRID, HPRD15249124 details
THA_HUMANMED25_HUMANBioGRID17641689 details
THA_HUMANARI5A_HUMANBioGRID15941852 details
THA_HUMANTF2B_HUMANBioGRID, HPRD7609079 details
THA_HUMANC1D_HUMANBioGRID9405624 details
THA_HUMANTHA_HUMANBioGRID19422879 details
THA_HUMANTEBP_HUMANBioGRID10691735 details
THA_HUMANRANB9_HUMANBioGRID16595702 details
THA_HUMANUBC9_HUMANBioGRID22930759 details
THA_HUMANTRI63_HUMANBioGRID26862156 details
THA_HUMANCREB1_HUMANBioGRID, HPRD12805224 details
THA_HUMANMEOX2_HUMANBioGRID32296183 details
THA_HUMANOASL_HUMANHPRD7776974 details
THA_HUMANESR1_HUMANHPRD9717844 details
THA_HUMANMED17_HUMANBioGRID, IntAct14576168 8710870 details
THA_HUMANP85A_HUMANDIP16966610 details
THA_HUMANCCND1_HUMANBioGRID, HPRD12048199 details
THA_HUMANEP300_HUMANBioGRID12371907 details
THA_HUMANHAIR_HUMANBioGRID11641275 details
THA_HUMANMED12_HUMANBioGRID10198638 8710870 details
THA_HUMANMED16_HUMANBioGRID10198638 8710870 details
THA_HUMANMED6_HUMANBioGRID10198638 details
THA_HUMANMED24_HUMANBioGRID10198638 11117530 8710870 details
THA_HUMANCDK8_HUMANBioGRID10198638 details
THA_HUMANPARP1_HUMANBioGRID15808511 17242407 details
THA_HUMANNCOA3_HUMANBioGRID11117530 details
THA_HUMANTAF7_HUMANBioGRID10409738 details
THA_HUMANEMD_HUMANBioGRID17620012 details
THA_HUMANSMC1A_HUMANBioGRID17242407 details
THA_HUMANDNLI3_HUMANBioGRID17242407 details
THA_HUMANXRCC5_HUMANBioGRID17242407 details
THA_HUMANXRCC6_HUMANBioGRID17242407 details
THA_HUMANHSP74_HUMANBioGRID17242407 details
THA_HUMANTBL1R_HUMANBioGRID17242407 details
THA_HUMANGPS2_HUMANBioGRID17242407 details
THA_HUMANMED14_HUMANBioGRID8710870 details
THA_HUMANTR150_HUMANBioGRID8710870 details
THA_HUMANIMA5_HUMANBioGRID31319097 details
THA_HUMANIMB1_HUMANBioGRID31319097 details
THA_HUMANIPO7_HUMANBioGRID31319097 details
THA_HUMANRXRB_HUMANHPRD1331778 details
THA_HUMANCBP_HUMANHPRD8616895 details
THA_HUMAN1433F_HUMANHPRD11266503 details
THA_HUMANPML_HUMANHPRD10610177 details
THA_HUMANHDAC2_HUMANHPRD10508171 details
THA_HUMANNSD1_HUMANHPRD9628876 details
THA_HUMANBTG1_HUMANHPRD15674337 details
THA_HUMANMOT8_HUMANHPRD12871948 details
THA_HUMANRXRG_HUMANHPRD8127707 details
THA_HUMANSRC_HUMANHPRD15140878 details
THA_HUMANCOT1_HUMANHPRD1331778 details