Entity Details

Primary name ITAM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11215
EntryNameITAM_HUMAN
FullNameIntegrin alpha-M
TaxID9606
Evidenceevidence at protein level
Length1152
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesITGAM

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001851 complement component C3b binding
GO:0005178 integrin binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0007155 cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010668 ectodermal cell differentiation
GO:0019221 cytokine-mediated signaling pathway
GO:0030198 extracellular matrix organization
GO:0030900 forebrain development
GO:0031072 heat shock protein binding
GO:0032930 positive regulation of superoxide anion generation
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034688 integrin alphaM-beta2 complex
GO:0035579 specific granule membrane
GO:0038024 cargo receptor activity
GO:0043312 neutrophil degranulation
GO:0043315 positive regulation of neutrophil degranulation
GO:0044853 plasma membrane raft
GO:0045087 innate immune response
GO:0045963 negative regulation of dopamine metabolic process
GO:0046872 metal ion binding
GO:0050900 leukocyte migration
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:0097190 apoptotic signaling pathway
GO:0097242 amyloid-beta clearance
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:0110090 positive regulation of hippocampal neuron apoptotic process
GO:0150062 complement-mediated synapse pruning
GO:0150064 vertebrate eye-specific patterning
GO:1901216 positive regulation of neuron death
GO:1904151 positive regulation of microglial cell mediated cytotoxicity
GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling
GO:2000363 positive regulation of prostaglandin-E synthase activity

Subcellular Location

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Subcellular Location
Cell membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR000413 Integrin alpha chainFamilyFamily
IPR002035 von Willebrand factor, type ADomainDomain
IPR013517 FG-GAP repeatRepeatRepeat
IPR013519 Integrin alpha beta-propellorRepeatRepeat
IPR013649 Integrin alpha-2DomainDomain
IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved siteSiteConserved site
IPR028994 Integrin alpha, N-terminalFamilyHomologous superfamily
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
609939 OMIMSystemic lupus erythematosus 6 (SLEB6)A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
ITAM_HUMANSOAT_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANKCNJ6_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANKI2L3_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANTMX2_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANCXA8_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANTM52B_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANCERS4_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANSYT2_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANCXB1_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANRUSF1_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANGORAB_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANMGST3_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANDHB13_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANPIGP_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANDKK4_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANPGRC2_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANSCN3B_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANMUC1_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANCLRN1_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANREEP4_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANT229B_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANKASH5_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANCR3L1_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANGPR42_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANMRM1_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANREEP2_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANEMC5_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANAR13B_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANABHGA_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
ITAM_HUMANPTN_HUMANUniProt28939773 details
ITAM_HUMANAUP1_HUMANBioGRID12042322 details
ITAM_HUMANUPAR_HUMANBioGRID, HPRD10744708 details
ITAM_HUMANICAM1_HUMANBioGRID, HPRD11073102 12208882 9488691 details
ITAM_HUMANJAM3_HUMANBioGRID, HPRD12208882 details
ITAM_HUMANBAP31_HUMANBioGRID15294914 details
ITAM_HUMANSHRPN_HUMANBioGRID24210817 details
ITAM_HUMANLMNA_HUMANBioGRID24623722 details
ITAM_HUMANTMM31_HUMANBioGRID32296183 details
ITAM_HUMANCLC4M_HUMANMINT16246332 details
ITAM_HUMANCD177_HUMANUniProt21193407 details
ITAM_HUMANITB2_HUMANHPRD, IntAct18083624 2454931 details
ITAM_HUMANPRTN3_HUMANBioGRID12960243 details
ITAM_HUMANIRAK1_HUMANBioGRID, HPRD11701612 details
ITAM_HUMANCO3_HUMANBioGRID, HPRD11073102 23134465 4062888 details
ITAM_HUMANAPOE_HUMANBioGRID23134465 details
ITAM_HUMANA4_HUMANBioGRID23134465 details
ITAM_HUMANICAM4_HUMANHPRD10846180 details
ITAM_HUMANELNE_HUMANHPRD15718918 details
ITAM_HUMANTHY1_HUMANHPRD15004192 details
ITAM_HUMANCFAH_HUMANHPRD9558116 details
ITAM_HUMANFIBG_HUMANHPRD11073102 9712878 details
ITAM_HUMANHPT_HUMANHPRD11967116 details
ITAM_HUMANICAM2_HUMANHPRD10352278 details
ITAM_HUMANGP1BA_HUMANHPRD10899906 details
ITAM_HUMANCD209_HUMANHPRD16246332 details