Entity Details

Primary name GFAP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14136
EntryNameGFAP_HUMAN
FullNameGlial fibrillary acidic protein
TaxID9606
Evidenceevidence at protein level
Length432
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesGFAP

GO terms

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GOName
GO:0005200 structural constituent of cytoskeleton
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0042802 identical protein binding
GO:0043254 regulation of protein-containing complex assembly
GO:0045109 intermediate filament organization
GO:0045111 intermediate filament cytoskeleton
GO:1904714 regulation of chaperone-mediated autophagy

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR006821 Intermediate filament head, DNA-binding domainDomainDomain
IPR018039 Intermediate filament protein, conserved siteSiteConserved site
IPR027701 Glial fibrillary acidic proteinFamilyFamily
IPR039008 Intermediate filament, rod domainDomainDomain

Diseases

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Disease IDSourceNameDescription
203450 OMIMAlexander disease (ALXDRD)A rare disorder of the central nervous system. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death within the first decade. Infants with Alexander disease develop a leukodystrophy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes. The disease is caused by variants affecting the gene represented in this entry.

Interactions

240 interactions

InteractorPartnerSourcesPublicationsLink
GFAP_HUMANPDLI1_HUMANBioGRID, HPRD, IntAct16189514 29892012 31515488 details
GFAP_HUMANK0408_HUMANBioGRID, HPRD, IntAct16189514 31515488 32814053 details
GFAP_HUMANPDLI7_HUMANBioGRID, HPRD, IntAct16189514 details
GFAP_HUMANVIME_HUMANBioGRID, HPRD, IntAct16189514 28514442 32296183 32814053 34079125 details
GFAP_HUMANSH3Y1_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
GFAP_HUMANP121A_HUMANBioGRID, HPRD, IntAct16189514 details
GFAP_HUMANGRAP2_HUMANBioGRID, HPRD, IntAct16189514 details
GFAP_HUMANRIBC2_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
GFAP_HUMANNHRF3_HUMANBioGRID, HPRD, IntAct16189514 32814053 details
GFAP_HUMANCEP76_HUMANBioGRID, HPRD, IntAct16189514 details
GFAP_HUMANA4_HUMANBioGRID, IntAct16049941 21832049 details
GFAP_HUMANSTAT1_HUMANBioGRID, IntAct20936779 details
GFAP_HUMANNEMO_HUMANBioGRID, IntAct21988832 details
GFAP_HUMANHD_HUMANIntAct17500595 32814053 details
GFAP_HUMANAKT1_HUMANBioGRID, MINT25640309 details
GFAP_HUMANMOS_HUMANBioGRID, IntAct25416956 details
GFAP_HUMANPIAS2_HUMANBioGRID, IntAct25416956 25910212 32296183 details
GFAP_HUMANTRI27_HUMANBioGRID, IntAct25416956 25910212 details
GFAP_HUMANK1C15_HUMANBioGRID, IntAct25416956 25910212 32296183 details
GFAP_HUMANRORA_HUMANBioGRID, IntAct25416956 details
GFAP_HUMANGOGA2_HUMANBioGRID, IntAct25416956 25910212 32296183 details
GFAP_HUMANRBTN2_HUMANBioGRID, IntAct25416956 details
GFAP_HUMANTLE5_HUMANBioGRID, IntAct25416956 details
GFAP_HUMANBIRC2_HUMANBioGRID, IntAct25416956 details
GFAP_HUMANZC21C_HUMANBioGRID, IntAct25416956 32814053 details
GFAP_HUMANCF206_HUMANBioGRID, IntAct25416956 details
GFAP_HUMANPPL13_HUMANBioGRID, IntAct25416956 31515488 32296183 details
GFAP_HUMANPIHD2_HUMANBioGRID, IntAct25416956 31515488 details
GFAP_HUMANNXF1_HUMANBioGRID, IntAct25416956 31515488 32296183 details
GFAP_HUMANFA50B_HUMANBioGRID, IntAct25416956 details
GFAP_HUMANGFAP_HUMANBioGRID, IntAct25416956 25910212 32296183 details
GFAP_HUMANNFL_HUMANBioGRID, IntAct26871637 32296183 32814053 details
GFAP_HUMANK1C19_HUMANBioGRID, IntAct25910212 32296183 32814053 34079125 details
GFAP_HUMANTBC21_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANLENG1_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANDESM_HUMANBioGRID, IntAct28514442 32296183 32814053 34079125 details
GFAP_HUMANK1C13_HUMANBioGRID, IntAct25416956 25910212 32296183 details
GFAP_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANZN774_HUMANBioGRID, IntAct32296183 32814053 details
GFAP_HUMANK1C27_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANNEK6_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANCCD57_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANK1C39_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANPP16B_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANC19L2_HUMANBioGRID, IntAct32296183 32814053 details
GFAP_HUMANTB22B_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANCDC37_HUMANBioGRID, IntAct24189400 32296183 details
GFAP_HUMANABI2_HUMANBioGRID, IntAct32296183 32814053 details
GFAP_HUMANTFP11_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANCT55_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANCAR10_HUMANBioGRID, IntAct32296183 34079125 details
GFAP_HUMANEPMIP_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANPPR18_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANUBS3A_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANMK09_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANYES_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANENKD1_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANZN655_HUMANBioGRID, IntAct32296183 details
GFAP_HUMANMBPHL_HUMANBioGRID, IntAct32296183 32814053 details
GFAP_HUMANSYNCI_HUMANBioGRID, IntAct28514442 32814053 details
GFAP_HUMANUBP10_HUMANBioGRID, IntAct28514442 32814053 details
GFAP_HUMANGCP4_HUMANBioGRID, HPRD, IntAct16189514 31515488 details
GFAP_HUMANFYN_HUMANIntAct32814053 details
GFAP_HUMANFANCG_HUMANIntAct32814053 details
GFAP_HUMANEXTL2_HUMANIntAct32814053 details
GFAP_HUMANDDIT3_HUMANIntAct32814053 details
GFAP_HUMANCTNB1_HUMANIntAct32814053 details
GFAP_HUMANERCC8_HUMANIntAct32814053 details
GFAP_HUMANCCNC_HUMANIntAct32814053 details
GFAP_HUMANCASP1_HUMANIntAct32814053 details
GFAP_HUMANCALM2_HUMANIntAct32814053 details
GFAP_HUMANVATB2_HUMANIntAct32814053 details
GFAP_HUMANAPLP2_HUMANIntAct32814053 details
GFAP_HUMANAL1A1_HUMANIntAct32814053 details
GFAP_HUMANAP2B1_HUMANIntAct32814053 details
GFAP_HUMANZSC9_HUMANIntAct32814053 details
GFAP_HUMANZNF20_HUMANIntAct32814053 details
GFAP_HUMANBRK1_HUMANIntAct32814053 details
GFAP_HUMANTHIO_HUMANIntAct32814053 details
GFAP_HUMANTSNAX_HUMANIntAct32814053 details
GFAP_HUMANBACD2_HUMANIntAct32814053 details
GFAP_HUMANSMRD1_HUMANIntAct32814053 details
GFAP_HUMANSNF5_HUMANBioGRID, IntAct27229929 32814053 details
GFAP_HUMANZNF19_HUMANIntAct32814053 details
GFAP_HUMANPER1_HUMANIntAct32814053 details
GFAP_HUMANPNPH_HUMANIntAct32814053 details
GFAP_HUMANNFX1_HUMANIntAct32814053 details
GFAP_HUMANNP1L3_HUMANIntAct32814053 details
GFAP_HUMANLASP1_HUMANIntAct32814053 details
GFAP_HUMANKT33B_HUMANIntAct32814053 details
GFAP_HUMANKIFC3_HUMANIntAct32814053 details
GFAP_HUMANIL16_HUMANIntAct32814053 details
GFAP_HUMANHNRPK_HUMANIntAct32814053 details
GFAP_HUMANGRB10_HUMANIntAct32814053 details
GFAP_HUMANDNJA3_HUMANIntAct32814053 details
GFAP_HUMANCDC23_HUMANIntAct32814053 details
GFAP_HUMANHYAL2_HUMANIntAct32814053 details
GFAP_HUMANTELT_HUMANIntAct32814053 details
GFAP_HUMANESS2_HUMANIntAct32814053 details
GFAP_HUMANDPF1_HUMANIntAct32814053 details
GFAP_HUMANUBXN8_HUMANIntAct32814053 details
GFAP_HUMANZN232_HUMANIntAct32814053 details
GFAP_HUMANPDLI5_HUMANIntAct32814053 details
GFAP_HUMANSLU7_HUMANIntAct32814053 details
GFAP_HUMANNEBL_HUMANIntAct32814053 details
GFAP_HUMANBAIP2_HUMANIntAct32814053 details
GFAP_HUMANMCRS1_HUMANIntAct32814053 details
GFAP_HUMANNOD1_HUMANIntAct32814053 details
GFAP_HUMANSPF27_HUMANIntAct32814053 details
GFAP_HUMANTOM1_HUMANIntAct32814053 details
GFAP_HUMANSPAT2_HUMANIntAct32814053 details
GFAP_HUMANRASF2_HUMANIntAct32814053 details
GFAP_HUMANJADE3_HUMANIntAct32814053 details
GFAP_HUMANMICA2_HUMANIntAct32814053 details
GFAP_HUMANSNR40_HUMANIntAct32814053 details
GFAP_HUMANPCSK7_HUMANIntAct32814053 details
GFAP_HUMANPKP3_HUMANIntAct32814053 details
GFAP_HUMANRASF1_HUMANIntAct32814053 details
GFAP_HUMANCPSF5_HUMANIntAct32814053 details
GFAP_HUMANDBF4A_HUMANIntAct32814053 details
GFAP_HUMANCRLF3_HUMANIntAct32814053 details
GFAP_HUMANASB3_HUMANIntAct32814053 details
GFAP_HUMANSCAPE_HUMANIntAct32814053 details
GFAP_HUMANMLRS_HUMANIntAct32814053 details
GFAP_HUMANKLH20_HUMANIntAct32814053 details
GFAP_HUMANSTK36_HUMANIntAct32814053 details
GFAP_HUMANPHF19_HUMANIntAct32814053 details
GFAP_HUMANZN500_HUMANIntAct32814053 details
GFAP_HUMANNSMF_HUMANIntAct32814053 details
GFAP_HUMANTM186_HUMANIntAct32814053 details
GFAP_HUMANST4A1_HUMANIntAct32814053 details
GFAP_HUMANRAB38_HUMANIntAct32814053 details
GFAP_HUMANZKSC5_HUMANIntAct32814053 details
GFAP_HUMANJIP2_HUMANIntAct32814053 details
GFAP_HUMANRYBP_HUMANIntAct32814053 details
GFAP_HUMANFOG2_HUMANIntAct32814053 details
GFAP_HUMANMLC1_HUMANIntAct32814053 details
GFAP_HUMANDIP2A_HUMANIntAct32814053 details
GFAP_HUMANLPIN1_HUMANIntAct32814053 details
GFAP_HUMANZHX3_HUMANIntAct32814053 details
GFAP_HUMANSNW1_HUMANIntAct32814053 details
GFAP_HUMANMSRB2_HUMANIntAct32814053 details
GFAP_HUMANOTUB1_HUMANIntAct32814053 details
GFAP_HUMANASIC4_HUMANIntAct32814053 details
GFAP_HUMANZN444_HUMANIntAct32814053 details
GFAP_HUMANTHAP1_HUMANIntAct32814053 details
GFAP_HUMANTASO2_HUMANIntAct32814053 details
GFAP_HUMANWWOX_HUMANIntAct32814053 details
GFAP_HUMANZN581_HUMANIntAct32814053 details
GFAP_HUMANBAHD1_HUMANIntAct32814053 details
GFAP_HUMANMTF2_HUMANIntAct32814053 details
GFAP_HUMANRASF8_HUMANIntAct32814053 details
GFAP_HUMANFAKD1_HUMANIntAct32814053 details
GFAP_HUMANTUT7_HUMANIntAct32814053 details
GFAP_HUMANNAA16_HUMANIntAct32814053 details
GFAP_HUMANPERP_HUMANIntAct32814053 details
GFAP_HUMANZN410_HUMANIntAct32814053 details
GFAP_HUMANELAP1_HUMANIntAct32814053 details
GFAP_HUMANOTU7B_HUMANIntAct32814053 details
GFAP_HUMANSKT_HUMANIntAct32814053 details
GFAP_HUMANZN302_HUMANIntAct32814053 details
GFAP_HUMANARFG1_HUMANIntAct32814053 details
GFAP_HUMANLEG9C_HUMANIntAct32814053 details
GFAP_HUMANFOXA2_HUMANIntAct32814053 details
GFAP_HUMANZSC22_HUMANIntAct32814053 details
GFAP_HUMANVSX2_HUMANIntAct32814053 details
GFAP_HUMANRUFY4_HUMANIntAct32814053 details
GFAP_HUMANOD3L2_HUMANIntAct32814053 details
GFAP_HUMANSPRE2_HUMANIntAct32814053 details
GFAP_HUMANLONF2_HUMANIntAct32814053 details
GFAP_HUMANSPRE1_HUMANIntAct32814053 details
GFAP_HUMANSAXO1_HUMANIntAct32814053 details
GFAP_HUMANMET27_HUMANIntAct32814053 details
GFAP_HUMANIQUB_HUMANIntAct32814053 details
GFAP_HUMANSAMD3_HUMANIntAct32814053 details
GFAP_HUMANPLB1_HUMANIntAct32814053 details
GFAP_HUMANLS14B_HUMANIntAct32814053 details
GFAP_HUMANTRI69_HUMANIntAct32814053 details
GFAP_HUMANZN572_HUMANIntAct32814053 details
GFAP_HUMANCF141_HUMANIntAct32814053 details
GFAP_HUMANICA1L_HUMANIntAct32814053 details
GFAP_HUMANPPR21_HUMANIntAct32814053 details
GFAP_HUMANH32_HUMANIntAct32814053 details
GFAP_HUMANSPA2L_HUMANIntAct32814053 details
GFAP_HUMANZN488_HUMANIntAct32814053 details
GFAP_HUMANRAB3I_HUMANIntAct32814053 details
GFAP_HUMANPNMA5_HUMANIntAct32814053 details
GFAP_HUMANLENG8_HUMANIntAct32814053 details
GFAP_HUMANRHPN1_HUMANIntAct32814053 details
GFAP_HUMANIFT20_HUMANIntAct32814053 details
GFAP_HUMANCC120_HUMANIntAct32814053 details
GFAP_HUMANPP16A_HUMANIntAct32814053 details
GFAP_HUMANLNX1_HUMANIntAct32814053 details
GFAP_HUMANSPT22_HUMANIntAct32814053 details
GFAP_HUMANABLM2_HUMANIntAct32814053 details
GFAP_HUMANDDI2_HUMANIntAct32814053 details
GFAP_HUMANWDR83_HUMANIntAct32814053 details
GFAP_HUMANRASF5_HUMANIntAct32814053 details
GFAP_HUMANZN436_HUMANIntAct32814053 details
GFAP_HUMANWDR61_HUMANIntAct32814053 details
GFAP_HUMANZKSC3_HUMANIntAct32814053 details
GFAP_HUMANPECA1_HUMANIntAct32814053 details
GFAP_HUMANP85A_HUMANIntAct32814053 details
GFAP_HUMANRAB5A_HUMANIntAct32814053 details
GFAP_HUMANWFS1_HUMANIntAct32814053 details
GFAP_HUMANJPH3_HUMANIntAct32814053 details
GFAP_HUMANMY15B_HUMANBioGRID16189514 details
GFAP_HUMANPSN1_HUMANBioGRID, HPRD12058025 details
GFAP_HUMANPSN2_HUMANBioGRID12058025 details
GFAP_HUMANMEN1_HUMANBioGRID, HPRD12169273 details
GFAP_HUMANHGS_HUMANBioGRID19019082 details
GFAP_HUMANCRYAB_HUMANBioGRID17590381 details
GFAP_HUMANAURKB_HUMANBioGRID12686604 details
GFAP_HUMANKPCG_HUMANBioGRID20395553 details
GFAP_HUMANUBE3A_HUMANBioGRID26506232 details
GFAP_HUMANASPP2_HUMANBioGRID32296183 details
GFAP_HUMANHOMEZ_HUMANBioGRID32296183 details
GFAP_HUMANCOGA1_HUMANMINT18804107 details
GFAP_HUMANSMAD2_HUMANIntAct20195357 details
GFAP_HUMANHMGB1_HUMANBioGRID, IntAct28514442 29382328 details
GFAP_HUMANCDK1_HUMANBioGRID, HPRD, IntAct12177195 29128334 7822264 details
GFAP_HUMANFXR1_HUMANMINT21653829 details
GFAP_HUMANFXR2_HUMANMINT21653829 details
GFAP_HUMANSMCA2_HUMANMINT21653829 details
GFAP_HUMANTSC1_HUMANMINT21653829 details
GFAP_HUMANPDC6I_HUMANBioGRID12771190 details
GFAP_HUMANBIP_HUMANBioGRID24189400 details
GFAP_HUMANAP2M1_HUMANBioGRID24189400 details
GFAP_HUMANUBS3B_HUMANBioGRID24189400 details
GFAP_HUMANERRFI_HUMANBioGRID24189400 details
GFAP_HUMANATOH1_HUMANBioGRID27542412 details
GFAP_HUMANTLR4_HUMANBioGRID29382328 details
GFAP_HUMANS10A1_HUMANHPRD10510252 details
GFAP_HUMANKPCA_HUMANHPRD2114109 2155236 7822264 9099667 details
GFAP_HUMANS100B_HUMANHPRD10510252 details
GFAP_HUMANSRC_HUMANHPRD11379820 details
GFAP_HUMANKAPCA_HUMANHPRD2114109 2155236 7822264 9099667 details
GFAP_HUMANROCK1_HUMANHPRD2114109 2155236 7822264 9099667 details