Entity Details

Primary name VINC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18206
EntryNameVINC_HUMAN
FullNameVinculin
TaxID9606
Evidenceevidence at protein level
Length1134
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesVCL

GO terms

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GOName
GO:0051893 regulation of focal adhesion assembly
GO:0032991 protein-containing complex
GO:1990357 terminal web
GO:0006936 muscle contraction
GO:0043297 apical junction assembly
GO:0002009 morphogenesis of an epithelium
GO:0005916 fascia adherens
GO:0070062 extracellular exosome
GO:0090136 epithelial cell-cell adhesion
GO:0002162 dystroglycan binding
GO:0034333 adherens junction assembly
GO:1903140 regulation of establishment of endothelial barrier
GO:0007155 cell adhesion
GO:0008013 beta-catenin binding
GO:0034774 secretory granule lumen
GO:0035633 maintenance of blood-brain barrier
GO:0005903 brush border
GO:0030336 negative regulation of cell migration
GO:0031625 ubiquitin protein ligase binding
GO:0005198 structural molecule activity
GO:0045294 alpha-catenin binding
GO:0090637 inner dense plaque of desmosome
GO:0070527 platelet aggregation
GO:1904813 ficolin-1-rich granule lumen
GO:0005576 extracellular region
GO:0005915 zonula adherens
GO:0044291 cell-cell contact zone
GO:0005829 cytosol
GO:0002102 podosome
GO:0030032 lamellipodium assembly
GO:0005912 adherens junction
GO:0007160 cell-matrix adhesion
GO:0035580 specific granule lumen
GO:0090636 outer dense plaque of desmosome
GO:0045296 cadherin binding
GO:0042383 sarcolemma
GO:0005886 plasma membrane
GO:0043312 neutrophil degranulation
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:1903561 extracellular vesicle
GO:0002576 platelet degranulation
GO:0030055 cell-substrate junction
GO:0043034 costamere
GO:0005911 cell-cell junction
GO:0045121 membrane raft
GO:1904702 regulation of protein localization to adherens junction
GO:0003779 actin binding
GO:0034394 protein localization to cell surface
GO:0048675 axon extension

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000633 Vinculin, conserved siteSiteConserved site
IPR006077 Vinculin/alpha-cateninFamilyFamily
IPR017997 VinculinFamilyFamily
IPR036723 Alpha-catenin/vinculin-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613255 OMIMCardiomyopathy, familial hypertrophic 15 (CMH15)A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. The disease is caused by variants affecting the gene represented in this entry.
611407 OMIMCardiomyopathy, dilated 1W (CMD1W)A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. The disease is caused by variants affecting the gene represented in this entry.

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
VINC_HUMANPR40A_HUMANBioGRID, HPRD, MINT15231748 details
VINC_HUMANPSME1_HUMANBioGRID, IntAct16169070 details
VINC_HUMANABI2_HUMANBioGRID, HPRD, IntAct16189514 29892012 details
VINC_HUMANBRME1_HUMANBioGRID, HPRD, IntAct16189514 details
VINC_HUMANTRIP6_HUMANBioGRID, HPRD, IntAct, MINT16189514 21516116 34079125 details
VINC_HUMANLPXN_HUMANBioGRID, IntAct, MINT21516116 32296183 details
VINC_HUMANBIRC6_HUMANBioGRID, IntAct23414517 details
VINC_HUMANPOMP_HUMANBioGRID, IntAct23414517 details
VINC_HUMANPAXI_HUMANBioGRID, HPRD, mbinfo10330411 20308429 26344197 30120307 34079125 7525621 7534286 8922390 9054445 details
VINC_HUMANTEKT1_HUMANBioGRID, IntAct25416956 details
VINC_HUMANVINC_HUMANBioGRID, IntAct25416956 details
VINC_HUMANTLN1_HUMANBioGRID, HPRD, IntAct15070891 15988023 18056416 26496610 26923917 details
VINC_HUMANCTNA1_HUMANBioGRID, DIP, HPRD, IntAct23292143 26496610 34079125 9700171 details
VINC_HUMANSAPC2_HUMANBioGRID, IntAct32296183 details
VINC_HUMANBCAR1_HUMANBioGRID, IntAct11577104 32296183 34079125 details
VINC_HUMANNEBL_HUMANBioGRID, IntAct32296183 details
VINC_HUMANVINEX_HUMANBioGRID, IntAct32296183 34079125 details
VINC_HUMANRAVR1_HUMANDIP, HPRD11724819 19523901 details
VINC_HUMANPRKN_HUMANIntAct32814053 details
VINC_HUMANOPTN_HUMANIntAct32814053 details
VINC_HUMANFUS_HUMANIntAct32814053 details
VINC_HUMANTGFI1_HUMANBioGRID9858471 details
VINC_HUMANNRAP_HUMANBioGRID, HPRD10320340 details
VINC_HUMANVASP_HUMANBioGRID, HPRD10882740 21451103 34079125 details
VINC_HUMANSRBS1_HUMANBioGRID, HPRD10085297 12765336 17082770 34079125 details
VINC_HUMANSRBS2_HUMANBioGRID, HPRD10521485 details
VINC_HUMANCLH1_HUMANBioGRID, HPRD8276759 details
VINC_HUMANDAG1_HUMANBioGRID18341635 details
VINC_HUMANTBA1A_HUMANBioGRID18341635 details
VINC_HUMANLYAM2_HUMANBioGRID, HPRD8609175 details
VINC_HUMANTRI15_HUMANBioGRID25450970 details
VINC_HUMANITA5_HUMANBioGRID18056416 details
VINC_HUMANENOX2_HUMANBioGRID32296183 details
VINC_HUMAN1433Z_HUMANBioGRID, MINT15161933 22863883 details
VINC_HUMANARPC2_HUMANmbinfo12473693 details
VINC_HUMANTT21B_HUMANBioGRID, IntAct27173435 unassigned1312 details
VINC_HUMANUBE2N_HUMANBioGRID, IntAct27173435 unassigned1312 details
VINC_HUMANCADH1_HUMANBioGRID25468996 9405455 9535896 details
VINC_HUMANCTNB1_HUMANBioGRID22720799 27684187 9405455 details
VINC_HUMANCOR2B_HUMANBioGRID, HPRD10224093 details
VINC_HUMANGELS_HUMANBioGRID, HPRD11577104 details
VINC_HUMANPAK4_HUMANBioGRID26598620 details
VINC_HUMANFOCAD_HUMANBioGRID22427331 details
VINC_HUMANVGFR2_HUMANBioGRID12820653 details
VINC_HUMANCADH5_HUMANBioGRID26923917 details
VINC_HUMANPHIP_HUMANBioGRID32273388 details
VINC_HUMANKPCA_HUMANHPRD11741957 details
VINC_HUMANACTN1_HUMANHPRD15988023 details
VINC_HUMANSRC_HUMANHPRD15229287 details
VINC_HUMANPKD1_HUMANHPRD11113628 details
VINC_HUMANACTS_HUMANHPRD7816144 details