Entity Details

Primary name ERCC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19447
EntryNameERCC3_HUMAN
FullNameGeneral transcription and DNA repair factor IIH helicase subunit XPB
TaxID9606
Evidenceevidence at protein level
Length782
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesERCC3

GO terms

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GOName
GO:0000112 nucleotide-excision repair factor 3 complex
GO:0000439 transcription factor TFIIH core complex
GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005675 transcription factor TFIIH holo complex
GO:0006265 DNA topological change
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0008022 protein C-terminus binding
GO:0008104 protein localization
GO:0008134 transcription factor binding
GO:0009411 response to UV
GO:0016032 viral process
GO:0016887 ATP hydrolysis activity
GO:0033683 nucleotide-excision repair, DNA incision
GO:0035315 hair cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043138 3'-5' DNA helicase activity
GO:0047485 protein N-terminus binding
GO:0048568 embryonic organ development
GO:0070911 global genome nucleotide-excision repair
GO:0097550 transcription preinitiation complex
GO:1901990 regulation of mitotic cell cycle phase transition

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001161 Helicase XPB/Ssl2FamilyFamily
IPR001650 Helicase, C-terminalDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032438 ERCC3/RAD25/XPB helicase, C-terminal domainDomainDomain
IPR032830 Helicase XPB/Ssl2, N-terminal domainDomainDomain

Diseases

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Disease IDSourceNameDescription
610651 OMIMXeroderma pigmentosum complementation group B (XP-B)An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. Some XP-B patients present features of Cockayne syndrome, including cachectic dwarfism, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. The phenotype combining xeroderma pigmentosum and Cockayne syndrome traits is referred to as XP-CS complex. The disease is caused by variants affecting the gene represented in this entry.
616390 OMIMTrichothiodystrophy 2, photosensitive (TTD2)A form of trichothiodystrophy, an autosomal recessive disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. The disease is caused by variants affecting the gene represented in this entry.

Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
ERCC3_HUMANPRS8_HUMANBioGRID, HPRD, IntAct9173976 details
ERCC3_HUMANANDR_HUMANBioGRID, MINT21157430 details
ERCC3_HUMANGOGA2_HUMANBioGRID, MINT21516116 details
ERCC3_HUMANIMA4_HUMANBioGRID, IntAct21988832 32296183 details
ERCC3_HUMANMSD2_HUMANBioGRID, IntAct21988832 details
ERCC3_HUMANXPC_HUMANBioGRID, DIP, HPRD, UniProt10734143 26278177 details
ERCC3_HUMANCDK7_HUMANBioGRID, HPRD, IntAct10082552 15220921 17643375 23602568 26340423 28514442 28977422 29568061 8521393 8692841 9130708 details
ERCC3_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
ERCC3_HUMANXIAP_HUMANBioGRID, IntAct25416956 31515488 details
ERCC3_HUMANCEP70_HUMANBioGRID, IntAct25416956 details
ERCC3_HUMANTF2H5_HUMANBioGRID, DIP, HPRD, IntAct15220921 16669699 19172752 24981860 26340423 26496610 28514442 details
ERCC3_HUMANMAGD1_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANCEP76_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANATL4_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANROP1A_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANFXR1_HUMANIntAct32296183 details
ERCC3_HUMANGO45_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANSNW1_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANTRI14_HUMANBioGRID, IntAct32296183 details
ERCC3_HUMANTRI27_HUMANBioGRID, IntAct31515488 32296183 details
ERCC3_HUMANTF2H4_HUMANBioGRID, DIP, HPRD, IntAct15220921 19172752 22939629 24981860 26340423 26344197 28514442 9118947 details
ERCC3_HUMANTF2H2_HUMANBioGRID, HPRD, IntAct15220921 17643375 19934020 24981860 26340423 26344197 28514442 28977422 8194529 9118947 details
ERCC3_HUMANMAT1_HUMANBioGRID, HPRD, IntAct15220921 17643375 26340423 28514442 8692842 9118947 details
ERCC3_HUMANBCR_HUMANBioGRID, HPRD, IntAct10403766 17643375 28514442 9874796 details
ERCC3_HUMANERCC2_HUMANBioGRID, DIP, HPRD, IntAct15220921 16669699 19934020 22678362 22939629 26340423 27193682 8152490 8652557 9118947 details
ERCC3_HUMANEFHC2_HUMANIntAct31515488 details
ERCC3_HUMANZSCA1_HUMANBioGRID, IntAct20211142 details
ERCC3_HUMANT2EA_HUMANBioGRID, HPRD25492609 7926747 8152490 details
ERCC3_HUMANT2EB_HUMANBioGRID, HPRD7926747 8152490 details
ERCC3_HUMANP53_HUMANBioGRID, HPRD12379483 32807901 7663514 8612585 details
ERCC3_HUMANE2F1_HUMANBioGRID9400991 details
ERCC3_HUMANCDK8_HUMANBioGRID10993082 details
ERCC3_HUMANCCNC_HUMANBioGRID10993082 details
ERCC3_HUMANMCF2_HUMANBioGRID10403766 details
ERCC3_HUMANCDC42_HUMANBioGRID10403766 details
ERCC3_HUMANTF2H1_HUMANBioGRID, HPRD, IntAct10403766 11259578 15220921 17643375 19934020 22939629 24981860 26340423 26344197 28514442 8194528 8652557 8692842 9118947 9130708 9173976 details
ERCC3_HUMANSMAD2_HUMANIntAct20195357 details
ERCC3_HUMANCCNH_HUMANBioGRID, HPRD, IntAct, UniProt10734143 15220921 17643375 19934020 26186194 26340423 28514442 8692842 9118947 details
ERCC3_HUMANRD23B_HUMANUniProt10734143 details
ERCC3_HUMANMLF1_HUMANIntAct25036637 details
ERCC3_HUMANMLF2_HUMANIntAct25036637 details
ERCC3_HUMANCHIP_HUMANIntAct25036637 details
ERCC3_HUMANTF2H3_HUMANBioGRID, HPRD, IntAct, MINT15220921 17643375 22939629 24981860 26340423 26344197 28514442 8194529 9118947 details
ERCC3_HUMANMCAF1_HUMANBioGRID19106100 details
ERCC3_HUMANRPB1_HUMANBioGRID16916636 32355176 details
ERCC3_HUMANERPG3_HUMANBioGRID16916636 details
ERCC3_HUMANERCC6_HUMANBioGRID16916636 details
ERCC3_HUMANCSN2_HUMANBioGRID17438371 details
ERCC3_HUMANMMS19_HUMANBioGRID11071939 details
ERCC3_HUMANRAD52_HUMANBioGRID, HPRD12372413 details
ERCC3_HUMANUVSSA_HUMANBioGRID22902626 32355176 details
ERCC3_HUMANUBXN7_HUMANBioGRID26389662 details
ERCC3_HUMANSPTA1_HUMANBioGRID16889989 details