Entity Details

Primary name RASA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP20936
EntryNameRASA1_HUMAN
FullNameRas GTPase-activating protein 1
TaxID9606
Evidenceevidence at protein level
Length1047
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesRASA1

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000281 mitotic cytokinesis
GO:0001570 vasculogenesis
GO:0001726 ruffle
GO:0001784 phosphotyrosine residue binding
GO:0001953 negative regulation of cell-matrix adhesion
GO:0005096 GTPase activator activity
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007162 negative regulation of cell adhesion
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
GO:0019870 potassium channel inhibitor activity
GO:0030833 regulation of actin filament polymerization
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0048013 ephrin receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0051020 GTPase binding
GO:0051252 regulation of RNA metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001936 Ras GTPase-activating domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR023152 Ras GTPase-activating protein, conserved siteSiteConserved site
IPR028554 Ras GTPase-activating protein 1FamilyFamily
IPR035652 RasGAP, SH3 domainDomainDomain
IPR035841 Ras GTPase-activating protein 1, N-terminal SH2 domainDomainDomain
IPR035842 Ras GTPase-activating protein 1, C-terminal SH2 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR039360 Ras GTPase-activating proteinFamilyFamily

Diseases

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Disease IDSourceNameDescription
608354 OMIMCapillary malformation-arteriovenous malformation 1 (CMAVM1)A disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome. CMAVM1 inheritance is autosomal dominant. The disease is caused by variants affecting the gene represented in this entry.

Interactions

109 interactions

InteractorPartnerSourcesPublicationsLink
RASA1_HUMANERBB3_HUMANBioGRID, MINT16273093 22973453 details
RASA1_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 24412244 details
RASA1_HUMANEGFR_HUMANBioGRID, HPRD, MINT1385407 16273093 1633149 1850098 22973453 8647858 details
RASA1_HUMANERBB4_HUMANBioGRID, MINT16273093 22973453 details
RASA1_HUMANRASH_HUMANBioGRID, HPRD, IntAct11389730 26721396 2833817 7628625 8663024 9219684 details
RASA1_HUMANTSC1_HUMANIntAct17355907 details
RASA1_HUMANGAB1_HUMANBioGRID, IntAct, MINT15574420 24728074 details
RASA1_HUMANRHG07_HUMANBioGRID, MINT19151751 24412244 details
RASA1_HUMANKHDR1_HUMANBioGRID, HPRD, IntAct11604231 1385407 1545818 7537265 8189062 8419471 9743338 details
RASA1_HUMANCPNS1_HUMANMINT18761085 details
RASA1_HUMANABI1_HUMANMINT20598684 details
RASA1_HUMANIGF1R_HUMANBioGRID, HPRD, MINT7642582 details
RASA1_HUMANCAV1_HUMANDIP, MINT15504032 20808760 details
RASA1_HUMANSOCS3_HUMANBioGRID, HPRD, MINT11331873 details
RASA1_HUMANNCK1_HUMANBioGRID, HPRD, IntAct10508618 21664272 9233798 details
RASA1_HUMANBBS10_HUMANBioGRID, MINT21900206 details
RASA1_HUMANEIF1_HUMANBioGRID, MINT21900206 details
RASA1_HUMANEZH2_HUMANBioGRID, MINT21900206 details
RASA1_HUMANKAIN_HUMANBioGRID, MINT21900206 details
RASA1_HUMANTRM2A_HUMANBioGRID, MINT21900206 details
RASA1_HUMANXRCC6_HUMANBioGRID, MINT21900206 details
RASA1_HUMANZN579_HUMANBioGRID, MINT21900206 details
RASA1_HUMANAPC_HUMANBioGRID, MINT24412244 details
RASA1_HUMANAURKA_HUMANBioGRID, MINT24412244 details
RASA1_HUMANBCL10_HUMANBioGRID, MINT24412244 details
RASA1_HUMANBMR1A_HUMANBioGRID, MINT24412244 details
RASA1_HUMANBUB1_HUMANBioGRID, MINT24412244 details
RASA1_HUMANARF_HUMANBioGRID, MINT24412244 details
RASA1_HUMANDCC_HUMANBioGRID, MINT24412244 details
RASA1_HUMANMLH3_HUMANBioGRID, MINT24412244 details
RASA1_HUMANRASN_HUMANBioGRID, MINT24412244 details
RASA1_HUMANPMS2_HUMANBioGRID, MINT24412244 details
RASA1_HUMANPTPRJ_HUMANBioGRID, MINT24412244 details
RASA1_HUMANRB_HUMANBioGRID, MINT24412244 details
RASA1_HUMANSMAD2_HUMANBioGRID, MINT24412244 details
RASA1_HUMANSTK11_HUMANBioGRID, MINT24412244 details
RASA1_HUMANANDR_HUMANBioGRID, IntAct24728074 details
RASA1_HUMANKIT_HUMANBioGRID, HPRD, IntAct11071635 24728074 details
RASA1_HUMANMET_HUMANBioGRID, IntAct24728074 details
RASA1_HUMANOLIG1_HUMANBioGRID, IntAct25814554 details
RASA1_HUMANGMCL1_HUMANBioGRID, IntAct32296183 details
RASA1_HUMANFLT3_HUMANMINT28086240 details
RASA1_HUMANHD_HUMANBioGRID, HPRD, IntAct32814053 9079622 details
RASA1_HUMANDOK1_HUMANBioGRID, HPRD10688886 10799545 10822173 11551902 15151996 22974441 9008161 9478921 9822717 details
RASA1_HUMANSL9A2_HUMANBioGRID, HPRD10187839 details
RASA1_HUMANRHG35_HUMANBioGRID8189062 8419471 9034330 details
RASA1_HUMANEPHB2_HUMANBioGRID, HPRD10644995 9233798 details
RASA1_HUMANSRC_HUMANBioGRID, HPRD11389730 1717825 details
RASA1_HUMANANXA6_HUMANBioGRID, HPRD10571081 8798684 details
RASA1_HUMANEPHB3_HUMANBioGRID, HPRD9674711 details
RASA1_HUMANDNJA3_HUMANBioGRID, HPRD11116152 details
RASA1_HUMANCSK_HUMANBioGRID, HPRD7544435 details
RASA1_HUMANCAV2_HUMANBioGRID, HPRD12091389 15504032 details
RASA1_HUMANHCK_HUMANBioGRID, HPRD7782336 details
RASA1_HUMANRACK1_HUMANBioGRID, HPRD11350068 details
RASA1_HUMANFAK2_HUMANBioGRID, HPRD10708762 10713673 details
RASA1_HUMANLCK_HUMANBioGRID, HPRD11389730 1850098 details
RASA1_HUMANA4_HUMANBioGRID21832049 details
RASA1_HUMANFGFR1_HUMANBioGRID8321198 details
RASA1_HUMANRASA1_HUMANBioGRID, HPRD11976319 31980649 details
RASA1_HUMANCDN2A_HUMANBioGRID24412244 details
RASA1_HUMANPDE6D_HUMANHPRD11786539 details
RASA1_HUMANAURKB_HUMANHPRD11976319 details
RASA1_HUMANPLCG1_HUMANBioGRID, MINT8977179 9020117 9743338 details
RASA1_HUMANINSR_HUMANBioGRID, HPRD, MINT1331107 9593725 details
RASA1_HUMANATF7_HUMANIntAct20195357 details
RASA1_HUMANPGFRB_HUMANBioGRID, HPRD, MINT10697503 11896619 1314164 1375321 8382774 details
RASA1_HUMANCD5_HUMANBioGRID, HPRD, MINT9603468 details
RASA1_HUMANSDC2_HUMANMolecular Connections22471946 details
RASA1_HUMANTE2IP_HUMANDIP25531777 details
RASA1_HUMANEPHA4_HUMANIntAct31413325 details
RASA1_HUMANDOK2_HUMANBioGRID, HPRD10428862 10508618 10799545 10822173 9478921 details
RASA1_HUMANM4K4_HUMANBioGRID, HPRD10669731 details
RASA1_HUMANPAXI_HUMANBioGRID, HPRD10092539 details
RASA1_HUMANZAP70_HUMANBioGRID, HPRD7760813 details
RASA1_HUMANYES_HUMANBioGRID, HPRD1544885 details
RASA1_HUMANVGFR2_HUMANBioGRID, HPRD10319320 details
RASA1_HUMANGRB2_HUMANBioGRID, HPRD12441060 details
RASA1_HUMANG3BP1_HUMANBioGRID, HPRD9632780 details
RASA1_HUMANSPSB1_HUMANBioGRID, HPRD15713673 details
RASA1_HUMANSOCS1_HUMANBioGRID18556463 29991678 details
RASA1_HUMANABL1_HUMANBioGRID, HPRD1383690 1571536 details
RASA1_HUMANNTRK1_HUMANBioGRID, HPRD25921289 8384556 details
RASA1_HUMANPGFRA_HUMANBioGRID7682895 details
RASA1_HUMANBCR_HUMANHPRD1383690 details
RASA1_HUMANCH60_HUMANHPRD1347942 details
RASA1_HUMANEPHA2_HUMANHPRD16051609 details
RASA1_HUMANLYN_HUMANHPRD8395016 details
RASA1_HUMANKSYK_HUMANHPRD9218456 details
RASA1_HUMANSHC1_HUMANHPRD8155326 details
RASA1_HUMANAF1L2_HUMANHPRD17412687 details
RASA1_HUMANPTPRC_HUMANHPRD8570203 details
RASA1_HUMANCSF1R_HUMANHPRD2172781 details
RASA1_HUMANP85A_HUMANHPRD1336372 details
RASA1_HUMANRAB5A_HUMANHPRD11536198 details
RASA1_HUMANRAP1A_HUMANHPRD2164710 details
RASA1_HUMANFES_HUMANHPRD7691175 details
RASA1_HUMANSYN1_HUMANHPRD10899172 details
RASA1_HUMANCASP3_HUMANHPRD10200531 details
RASA1_HUMANSTAU1_HUMANHPRD15121898 details
RASA1_HUMANCASP7_HUMANHPRD10200531 details
RASA1_HUMANWWP1_HUMANHPRD9169421 details
RASA1_HUMANWWP2_HUMANHPRD9169421 details
RASA1_HUMANMAGI1_HUMANHPRD9169421 details
RASA1_HUMANRHG05_HUMANHPRD8537347 details
RASA1_HUMANRHG01_HUMANHPRD9034330 details
RASA1_HUMANBIRC5_HUMANHPRD11976319 details
RASA1_HUMANPHAG1_HUMANHPRD10790433 details
RASA1_HUMANDOK4_HUMANHPRD12730241 details