Entity Details

Primary name PSB8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28062
EntryNamePSB8_HUMAN
FullNameProteasome subunit beta type-8
TaxID9606
Evidenceevidence at protein level
Length276
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPSMB8

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0006521 regulation of cellular amino acid metabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019774 proteasome core complex, beta-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0045444 fat cell differentiation
GO:0050852 T cell receptor signaling pathway
GO:0052548 regulation of endopeptidase activity
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060337 type I interferon signaling pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990111 spermatoproteasome complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000243 Peptidase T1A, proteasome beta-subunitFamilyFamily
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR016050 Proteasome beta-type subunit, conserved siteSiteConserved site
IPR023333 Proteasome B-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR035705 Proteasome subunit beta type 8FamilyFamily

Diseases

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Disease IDSourceNameDescription
256040 OMIMProteasome-associated autoinflammatory syndrome 1 (PRAAS1)An autosomal recessive autoinflammatory disorder characterized by early childhood onset of recurrent fever, joint stiffness and severe contractures of the hands and feet, and erythematous skin lesions with subsequent development of lipodystrophy and laboratory evidence of immune dysregulation. Accompanying features may include muscle weakness and atrophy, hepatosplenomegaly, and microcytic anemia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB08889 CarfilzomibDrugbanksmall molecule

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
PSB8_HUMANLSM1_HUMANBioGRID, HPRD, IntAct15231747 32296183 details
PSB8_HUMANTAP1_HUMANBioGRID, HPRD, IntAct15488952 details
PSB8_HUMANTAP2_HUMANBioGRID, HPRD, IntAct15488952 details
PSB8_HUMANPSB7_HUMANBioGRID, IntAct16423992 17948026 20723761 22863883 22939629 26344197 details
PSB8_HUMANGNA1_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANREL_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANPCH2_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANTRAF3_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANUBAP2_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANRPB7_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANZMY12_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANDUS23_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANSNX5_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANYJEN3_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANPFD5_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANWWOX_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANTET5B_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANGRN_HUMANIntAct32814053 details
PSB8_HUMANHSPB1_HUMANIntAct32814053 details
PSB8_HUMANWFS1_HUMANIntAct32814053 details
PSB8_HUMANKIF1B_HUMANIntAct32814053 details
PSB8_HUMANRNF11_HUMANIntAct32814053 details
PSB8_HUMANSODC_HUMANIntAct32814053 details
PSB8_HUMANA4_HUMANIntAct32814053 details
PSB8_HUMANHD_HUMANIntAct32814053 details
PSB8_HUMANATX1_HUMANIntAct32814053 details
PSB8_HUMANTADBP_HUMANIntAct32814053 details
PSB8_HUMANPSB1_HUMANBioGRID17506986 17948026 22863883 22939629 26344197 details
PSB8_HUMANPSB9_HUMANBioGRID17506986 17948026 details
PSB8_HUMANPOMP_HUMANBioGRID15944226 17948026 details
PSB8_HUMANMDR1_HUMANBioGRID15488952 details
PSB8_HUMANPSB4_HUMANBioGRID17948026 22863883 22939629 26344197 details
PSB8_HUMANPSB3_HUMANBioGRID17948026 22939629 26344197 details
PSB8_HUMANPSB6_HUMANBioGRID11745344 17948026 22863883 22939629 26344197 details
PSB8_HUMANPSB8_HUMANBioGRID, HPRD1429565 17948026 details
PSB8_HUMANPSB10_HUMANBioGRID17948026 details
PSB8_HUMANPSA6_HUMANBioGRID17948026 22863883 22939629 26344197 details
PSB8_HUMANMEOX2_HUMANBioGRID32296183 details
PSB8_HUMANPSA2_HUMANBioGRID, IntAct15887188 19193609 20937868 22863883 22939629 26344197 31114588 details
PSB8_HUMANPSA1_HUMANBioGRID, IntAct22863883 22939629 26344197 29568061 8206875 details
PSB8_HUMANPSA4_HUMANBioGRID15303969 22863883 22939629 26344197 9311996 details
PSB8_HUMANUBP7_HUMANBioGRID19193609 details
PSB8_HUMANPSME1_HUMANBioGRID11745344 details
PSB8_HUMANPSME2_HUMANBioGRID11745344 details