Entity Details

Primary name TYK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29597
EntryNameTYK2_HUMAN
FullNameNon-receptor tyrosine-protein kinase TYK2
TaxID9606
Evidenceevidence at protein level
Length1187
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesTYK2

GO terms

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GOName
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005131 growth hormone receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006468 protein phosphorylation
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0031702 type 1 angiotensin receptor binding
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0070062 extracellular exosome
GO:0070106 interleukin-27-mediated signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016045 Tyrosine-protein kinase, non-receptor, TYK2, N-terminalDomainDomain
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

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Disease IDSourceNameDescription
611521 OMIMImmunodeficiency 35 (IMD35)A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB08895 TofacitinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
TYK2_HUMANINAR1_HUMANBioGRID, DIP, HPRD, MINT10523853 15337770 15356134 18474601 24704786 95059042 9677371 9733772 details
TYK2_HUMANUBE2F_HUMANIntAct19549727 details
TYK2_HUMANKHDR2_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
TYK2_HUMANDYN2_HUMANBioGRID, MINT21900206 details
TYK2_HUMANKITH_HUMANBioGRID, MINT21900206 details
TYK2_HUMANFHL3_HUMANBioGRID, IntAct21516116 25416956 32296183 details
TYK2_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
TYK2_HUMANHNRPK_HUMANBioGRID, IntAct25416956 29892012 32296183 details
TYK2_HUMANTRAF4_HUMANBioGRID, IntAct25416956 details
TYK2_HUMANKHDR3_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANGG6L9_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANAKP8L_HUMANIntAct32296183 details
TYK2_HUMANAGR2_HUMANIntAct32296183 details
TYK2_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANPRDM5_HUMANBioGRID, IntAct32296183 details
TYK2_HUMANRACK1_HUMANBioGRID, HPRD12960323 details
TYK2_HUMANSTAT1_HUMANBioGRID, HPRD10918587 11294897 11839738 12637327 12817007 12960323 15322115 7543024 7657660 7690989 details
TYK2_HUMANANM5_HUMANBioGRID, HPRD10531356 details
TYK2_HUMANLYN_HUMANBioGRID, HPRD9633884 details
TYK2_HUMANPTN6_HUMANBioGRID, HPRD7629131 8780698 details
TYK2_HUMANFYN_HUMANBioGRID, HPRD9196040 details
TYK2_HUMANIRS2_HUMANBioGRID, HPRD8550573 details
TYK2_HUMANSOCS1_HUMANBioGRID21757742 29674694 29991678 details
TYK2_HUMANE2AK2_HUMANBioGRID, HPRD17290288 details
TYK2_HUMANCSN5_HUMANBioGRID24043623 details
TYK2_HUMANSIVA_HUMANBioGRID20727854 details
TYK2_HUMANASPP2_HUMANBioGRID32296183 details
TYK2_HUMANJKIP1_HUMANHPRD15277531 details
TYK2_HUMANKPCA_HUMANMINT17290288 details
TYK2_HUMANPTN1_HUMANBioGRID, HPRD, MINT11694501 details
TYK2_HUMANHS90B_HUMANIntAct22939624 details
TYK2_HUMANJAK2_HUMANIntAct26175413 details
TYK2_HUMANSTAT2_HUMANHPRD, IntAct32953130 8605877 details
TYK2_HUMANXRCC5_HUMANBioGRID, HPRD10673353 details
TYK2_HUMANVAV_HUMANBioGRID, HPRD10673353 details
TYK2_HUMANCRKL_HUMANBioGRID, HPRD9374471 details
TYK2_HUMANJAK1_HUMANBioGRID, HPRD7589562 8702790 details
TYK2_HUMANTYK2_HUMANBioGRID, HPRD7589562 details
TYK2_HUMANELP2_HUMANBioGRID10954736 details
TYK2_HUMANI13R1_HUMANBioGRID, HPRD10409622 details
TYK2_HUMANCBL_HUMANBioGRID, HPRD8780698 details
TYK2_HUMANUPAR_HUMANBioGRID, HPRD9417082 9974409 details
TYK2_HUMANIL6RB_HUMANBioGRID, HPRD9388212 details
TYK2_HUMANSTAM2_HUMANBioGRID, HPRD10899310 details
TYK2_HUMANGHR_HUMANBioGRID, HPRD10502458 details
TYK2_HUMANKLF10_HUMANBioGRID21471442 details
TYK2_HUMANLNX1_HUMANBioGRID22087225 details
TYK2_HUMANPTAFR_HUMANBioGRID, HPRD14500680 details
TYK2_HUMANHS90A_HUMANBioGRID22939624 details
TYK2_HUMANJAK3_HUMANBioGRID12207328 details
TYK2_HUMANSIAH2_HUMANBioGRID24833526 details
TYK2_HUMANUB2L6_HUMANBioGRID24833526 details
TYK2_HUMANPTN11_HUMANBioGRID9794795 details
TYK2_HUMANSOCS2_HUMANBioGRID28496097 details
TYK2_HUMANP85A_HUMANHPRD10995743 details
TYK2_HUMANINAR2_HUMANHPRD12960323 details
TYK2_HUMANPGFRB_HUMANHPRD8657151 9484840 details
TYK2_HUMANIRS1_HUMANHPRD8550573 details
TYK2_HUMANPTPRC_HUMANHPRD11201744 details