Entity Details

Primary name AKT2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31751
EntryNameAKT2_HUMAN
FullNameRAC-beta serine/threonine-protein kinase
TaxID9606
Evidenceevidence at protein level
Length481
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesAKT2

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006417 regulation of translation
GO:0006464 cellular protein modification process
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0008286 insulin receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010907 positive regulation of glucose metabolic process
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0018105 peptidyl-serine phosphorylation
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0031340 positive regulation of vesicle fusion
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0032287 peripheral nervous system myelin maintenance
GO:0032587 ruffle membrane
GO:0032869 cellular response to insulin stimulus
GO:0032991 protein-containing complex
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045444 fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0046326 positive regulation of glucose import
GO:0046872 metal ion binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060644 mammary gland epithelial cell differentiation
GO:0065002 intracellular protein transmembrane transport
GO:0071486 cellular response to high light intensity
GO:0072659 protein localization to plasma membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:0090630 activation of GTPase activity
GO:0097473 retinal rod cell apoptotic process
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000147 positive regulation of cell motility

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Early endosome
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR034677 Protein Kinase B beta, catalytic domainDomainDomain
IPR039026 Protein Kinase B, pleckstrin homology domainDomainDomain

Diseases

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Disease IDSourceNameDescription
125853 OMIMDiabetes mellitus, non-insulin-dependent (NIDDM)A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. The disease is caused by variants affecting the gene represented in this entry.
240900 OMIMHypoinsulinemic hypoglycemia with hemihypertrophy (HIHGHH)A disorder characterized by hypoglycemia, low insulin levels, low serum levels of ketone bodies and branched-chain amino acids, left-sided hemihypertrophy, neonatal macrosomia, reduced consciousness and hypoglycemic seizures. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB07812 N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamideDrugbanksmall molecule
DB07859 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDrugbanksmall molecule
DB07947 ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDrugbanksmall molecule
DB08073 (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDrugbanksmall molecule

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
AKT2_HUMANPRKDC_HUMANBioGRID15678105 16221682 details
AKT2_HUMANMTCP1_HUMANBioGRID, HPRD10983986 11707444 details
AKT2_HUMANGSK3B_HUMANBioGRID, HPRD, IntAct12434148 details
AKT2_HUMANPICK1_HUMANBioGRID, IntAct32296183 details
AKT2_HUMANDP13A_HUMANBioGRID, HPRD10490823 17030088 details
AKT2_HUMANTCL1A_HUMANBioGRID, HPRD10983986 11707444 details
AKT2_HUMANCCL14_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANREL_HUMANBioGRID, IntAct32296183 details
AKT2_HUMANPKHO1_HUMANBioGRID17942896 details
AKT2_HUMANAP2C_HUMANIntAct24835590 details
AKT2_HUMANCASP3_HUMANMINT17544405 details
AKT2_HUMANOFUT1_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANTMED2_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANSTEA4_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANESR1_HUMANBioGRID, HPRD11139588 11432835 11507039 9528769 details
AKT2_HUMANHS90A_HUMANBioGRID, HPRD11988487 22939624 details
AKT2_HUMANMEOX2_HUMANBioGRID32296183 details
AKT2_HUMANABCG8_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANSH3R1_HUMANBioGRID, HPRD, IntAct14504284 17535800 32296183 details
AKT2_HUMANAPOB_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANLRRK2_HUMANIntAct24947832 details
AKT2_HUMANCLIP3_HUMANBioGRID19139280 details
AKT2_HUMANPI51C_HUMANBioGRID26149501 details
AKT2_HUMANSNAI1_HUMANBioGRID22158034 details
AKT2_HUMANSPR2A_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANRPA2_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANPDK1_HUMANIntAct27505672 details
AKT2_HUMANUCHL1_HUMANBioGRID28636190 details
AKT2_HUMANA4_HUMANBioGRID21832049 details
AKT2_HUMANBIEA_HUMANBioGRID27166089 details
AKT2_HUMANAPOA1_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANTTC3_HUMANBioGRID, UniProt20059950 details
AKT2_HUMANSNX27_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANNAMPT_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANVHL_HUMANBioGRID27563096 details
AKT2_HUMANVINEX_HUMANBioGRID, IntAct32296183 details
AKT2_HUMANH31_HUMANBioGRID22158034 details
AKT2_HUMANPLPL3_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANSRBS2_HUMANBioGRID, IntAct21988832 details
AKT2_HUMANCDN1A_HUMANBioGRID16982699 details
AKT2_HUMANTCL1B_HUMANBioGRID, HPRD10983986 11707444 details
AKT2_HUMANTRIB3_HUMANBioGRID, HPRD12791994 30071535 details
AKT2_HUMANSKI_HUMANBioGRID19875456 details
AKT2_HUMANAKT1_HUMANBioGRID, HPRD, IntAct11278835 11445557 11546794 12149249 12176337 14500673 28514442 9736715 details
AKT2_HUMANFSHR_HUMANBioGRID, HPRD15070827 details
AKT2_HUMANEGLN1_HUMANBioGRID27563096 details
AKT2_HUMANHS90B_HUMANIntAct22939624 details
AKT2_HUMANAKT2_HUMANHPRD12434148 details
AKT2_HUMANPDPK1_HUMANBioGRID, HPRD12048203 27563096 9374542 9512493 details
AKT2_HUMANTSC2_HUMANHPRD12167664 details
AKT2_HUMANPFKAP_HUMANBioGRID29038421 details
AKT2_HUMANAKTS1_HUMANHPRD12524439 14973226 details
AKT2_HUMANGLUT4_HUMANHPRD11500317 details
AKT2_HUMANVIME_HUMANBioGRID, I2D20856200 details
AKT2_HUMANGBB1_HUMANBioGRID26895380 details
AKT2_HUMANSETB1_HUMANBioGRID, IntAct17577629 details
AKT2_HUMANCCNA2_HUMANDIP24670654 details
AKT2_HUMANKPCZ_HUMANBioGRID18353613 details
AKT2_HUMANFOXO4_HUMANHPRD11313479 details
AKT2_HUMANXIAP_HUMANHPRD14645242 details
AKT2_HUMANARRB2_HUMANDIP19122674 details
AKT2_HUMANPP2AA_HUMANBioGRID27563096 details
AKT2_HUMANRAB3D_HUMANHPRD11903042 details
AKT2_HUMANIKKA_HUMANHPRD12048203 details
AKT2_HUMANCUL1_HUMANBioGRID29103612 details
AKT2_HUMANFKBP5_HUMANBioGRID28363942 details
AKT2_HUMANCDC37_HUMANIntAct12176997 details
AKT2_HUMANWDR26_HUMANBioGRID26895380 details