Entity Details

Primary name C2TA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP33076
EntryNameC2TA_HUMAN
FullNameMHC class II transactivator
TaxID9606
Evidenceevidence at protein level
Length1130
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCIITA

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0003713 transcription coactivator activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008022 protein C-terminus binding
GO:0016605 PML body
GO:0016746 acyltransferase activity
GO:0032966 negative regulation of collagen biosynthetic process
GO:0034341 response to interferon-gamma
GO:0044877 protein-containing complex binding
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046597 negative regulation of viral entry into host cell
GO:0046677 response to antibiotic
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR008095 MHC class II transactivatorFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
209920 OMIMBare lymphocyte syndrome 2 (BLS2)A severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections. The disease is caused by variants affecting the gene represented in this entry.

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
C2TA_HUMANZXDC_HUMANHPRD, UniProt16600381 17493635 details
C2TA_HUMANZXDA_HUMANUniProt17493635 details
C2TA_HUMANRFX5_HUMANBioGRID, HPRD, IntAct10938133 11003667 12697811 26871568 9177217 details
C2TA_HUMANNCOA1_HUMANBioGRID, HPRD12933903 details
C2TA_HUMANRFXK_HUMANBioGRID, HPRD11003667 11463838 details
C2TA_HUMANXPO1_HUMANBioGRID, HPRD12517958 18245089 details
C2TA_HUMANMK01_HUMANBioGRID18245089 details
C2TA_HUMANCDK1_HUMANBioGRID18245089 details
C2TA_HUMANHDAC2_HUMANBioGRID12697811 17991736 19041327 details
C2TA_HUMANHDAC1_HUMANBioGRID12697811 details
C2TA_HUMANSMCA4_HUMANBioGRID12077331 details
C2TA_HUMANGSK3B_HUMANBioGRID17991736 details
C2TA_HUMANPRS8_HUMANBioGRID18215421 20351748 26871568 details
C2TA_HUMANTF2B_HUMANBioGRID9177216 details
C2TA_HUMANTAF9_HUMANBioGRID9177216 details
C2TA_HUMANKAT2B_HUMANBioGRID, HPRD11046145 28286521 details
C2TA_HUMANSIR1_HUMANUniProt21890893 details
C2TA_HUMANMK03_HUMANBioGRID18245089 details
C2TA_HUMANHDAC4_HUMANBioGRID, HPRD15964851 details
C2TA_HUMANHDAC5_HUMANBioGRID, HPRD15964851 details
C2TA_HUMANSIN3B_HUMANBioGRID17991736 details
C2TA_HUMANPRS7_HUMANBioGRID20351748 details
C2TA_HUMANPRS6A_HUMANBioGRID20351748 details
C2TA_HUMANPPARG_HUMANBioGRID17611194 details
C2TA_HUMANEP300_HUMANBioGRID26871568 details
C2TA_HUMANEP400_HUMANBioGRID26871568 details
C2TA_HUMANTBP_HUMANBioGRID26871568 details
C2TA_HUMANTRI22_HUMANBioGRID28555140 details
C2TA_HUMANPML_HUMANBioGRID28555140 details
C2TA_HUMANCCNT1_HUMANBioGRID28555140 details
C2TA_HUMANNFYB_HUMANHPRD11003667 details
C2TA_HUMANKAPCA_HUMANHPRD11416140 details
C2TA_HUMANTAF6_HUMANHPRD9177216 details