Entity Details

Primary name ATP7B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35670
EntryNameATP7B_HUMAN
FullNameCopper-transporting ATPase 2
TaxID9606
Evidenceevidence at protein level
Length1465
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesATP7B

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005375 copper ion transmembrane transporter activity
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0006825 copper ion transport
GO:0006878 cellular copper ion homeostasis
GO:0015677 copper ion import
GO:0016020 membrane
GO:0032588 trans-Golgi network membrane
GO:0034220 ion transmembrane transport
GO:0043682 P-type divalent copper transporter activity
GO:0046688 response to copper ion
GO:0051208 sequestering of calcium ion
GO:0060003 copper ion export
GO:0140581 P-type monovalent copper transporter activity
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus
Golgi apparatus membrane
Late endosome
Mitochondrion

Domains

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DomainNameCategoryType
IPR001757 P-type ATPaseFamilyFamily
IPR006121 Heavy metal-associated domain, HMADomainDomain
IPR006122 Heavy metal-associated domain, copper ion-bindingDomainDomain
IPR008250 P-type ATPase, A domain superfamilyFamilyHomologous superfamily
IPR017969 Heavy-metal-associated, conserved siteSiteConserved site
IPR018303 P-type ATPase, phosphorylation sitePTMPTM
IPR023298 P-type ATPase, transmembrane domain superfamilyFamilyHomologous superfamily
IPR023299 P-type ATPase, cytoplasmic domain NFamilyHomologous superfamily
IPR027256 P-type ATPase, subfamily IBFamilyFamily
IPR036163 Heavy metal-associated domain superfamilyFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR044492 P-type ATPase, haloacid dehalogenase domainDomainDomain

Diseases

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Disease IDSourceNameDescription
277900 OMIMWilson disease (WD)An autosomal recessive disorder of copper metabolism in which copper cannot be incorporated into ceruloplasmin in liver, and cannot be excreted from the liver into the bile. Copper accumulates in the liver and subsequently in the brain and kidney. The disease is characterized by neurologic manifestations and signs of cirrhosis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB09130 CopperDrugbanksmall molecule