Entity Details

Primary name STAT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42224
EntryNameSTAT1_HUMAN
FullNameSignal transducer and activator of transcription 1-alpha/beta
TaxID9606
Evidenceevidence at protein level
Length750
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesSTAT1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001937 negative regulation of endothelial cell proliferation
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002230 positive regulation of defense response to virus by host
GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006952 defense response
GO:0007221 positive regulation of transcription of Notch receptor target
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0008015 blood circulation
GO:0010742 macrophage derived foam cell differentiation
GO:0016032 viral process
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019899 enzyme binding
GO:0030424 axon
GO:0030425 dendrite
GO:0032727 positive regulation of interferon-alpha production
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034097 response to cytokine
GO:0035035 histone acetyltransferase binding
GO:0035456 response to interferon-beta
GO:0035458 cellular response to interferon-beta
GO:0038113 interleukin-9-mediated signaling pathway
GO:0038114 interleukin-21-mediated signaling pathway
GO:0042127 regulation of cell population proliferation
GO:0042393 histone binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043434 response to peptide hormone
GO:0044389 ubiquitin-like protein ligase binding
GO:0045296 cadherin binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046725 negative regulation by virus of viral protein levels in host cell
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051591 response to cAMP
GO:0051607 defense response to virus
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060337 type I interferon signaling pathway
GO:0061326 renal tubule development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070757 interleukin-35-mediated signaling pathway
GO:0071346 cellular response to interferon-gamma
GO:0072136 metanephric mesenchymal cell proliferation involved in metanephros development
GO:0072162 metanephric mesenchymal cell differentiation
GO:0072308 negative regulation of metanephric nephron tubule epithelial cell differentiation
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001217 Transcription factor STATFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR012345 STAT transcription factor, DNA-binding, N-terminalFamilyHomologous superfamily
IPR013799 STAT transcription factor, protein interactionDomainDomain
IPR013800 STAT transcription factor, all-alpha domainDomainDomain
IPR013801 STAT transcription factor, DNA-bindingDomainDomain
IPR015988 STAT transcription factor, coiled coilFamilyHomologous superfamily
IPR022752 Signal transducer and activation of transcription 1, TAZ2 binding domain, C-terminalDomainDomain
IPR035859 STAT1, SH2 domainDomainDomain
IPR036535 STAT transcription factor, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR038295 STAT1, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
614892 OMIMImmunodeficiency 31A (IMD31A)A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD31A has low penetrance, and affected individuals have relatively mild disease and good prognosis. IMD31A confers a predisposition to mycobacterial infections only, with no increased susceptibility to viral infections. The disease is caused by variants affecting the gene represented in this entry.
613796 OMIMImmunodeficiency 31B (IMD31B)A disorder characterized by susceptibility to severe mycobacterial and viral infections. Affected individuals can develop disseminated infections and die of viral illness. The disease is caused by variants affecting the gene represented in this entry.
614162 OMIMImmunodeficiency 31C (IMD31C)A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. The disease is caused by variants affecting the gene represented in this entry. STAT1 mutations in patients with autosomal dominant candidiasis lead to defective responses of type 1 and type 17 helper T-cells, characterized by reduced production of interferon-alpha, interleukin-17, and interleukin-22. These cytokines are crucial for the antifungal defense of skin and mucosa (PubMed:21714643).

Interactions

163 interactions

InteractorPartnerSourcesPublicationsLink
STAT1_HUMANRBTN2_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
STAT1_HUMANEIF1A_HUMANBioGRID, HPRD, IntAct16189514 25416956 details
STAT1_HUMANERBB2_HUMANBioGRID, IntAct, MINT16273093 25241761 details
STAT1_HUMANNMI_HUMANBioGRID, HPRD, IntAct9989503 details
STAT1_HUMANSTAT2_HUMANBioGRID, HPIDb, HPRD, IntAct, MINT10446176 10490982 12048190 15825084 17923090 24065129 26966684 28514442 31836668 8605877 8621447 9724754 details
STAT1_HUMANIRF9_HUMANBioGRID, HPRD, IntAct, MINT17923090 24065129 8943351 details
STAT1_HUMANE2F1_HUMANBioGRID, IntAct20195357 details
STAT1_HUMANINGR1_HUMANBioGRID, HPRD, MINT10848598 15494521 15780933 21689637 7514165 8156998 8662591 details
STAT1_HUMANEGFR_HUMANBioGRID, HPRD, IntAct, MINT10358079 10918587 11294897 11839738 12070153 12637327 12817007 15284024 15322115 23956138 24658140 24797263 25402006 31980649 7543024 7657660 7690989 details
STAT1_HUMANINAR2_HUMANBioGRID, HPRD, MINT11301323 29997210 32123171 9121453 details
STAT1_HUMANSTAT1_HUMANBioGRID, DIP, HPRD, MINT12873986 14704793 15284440 15780933 16007122 18591661 21914072 32814877 8605877 8621447 9630226 details
STAT1_HUMANIL6RB_HUMANMINT8662591 details
STAT1_HUMANSTAT3_HUMANBioGRID, DIP, HPRD, IntAct, MINT11594781 11722592 12070153 16007122 25241761 25609649 26966684 28514442 31462771 8662591 details
STAT1_HUMANACTN4_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANDCTN1_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANGFAP_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANHS90B_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANSHAN1_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANSPTN1_HUMANBioGRID, IntAct, MINT20936779 26966684 details
STAT1_HUMANSPTB2_HUMANBioGRID, IntAct20936779 details
STAT1_HUMANDDB1_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANHCDH_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANHLAB_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANNU4LM_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANNCPR_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANRXRA_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANNOMO1_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANNOMO2_HUMANBioGRID, IntAct21988832 details
STAT1_HUMANMAVS_HUMANBioGRID, IntAct21903422 details
STAT1_HUMANKIT_HUMANBioGRID, HPRD, IntAct25241761 9355737 details
STAT1_HUMANFAK1_HUMANBioGRID, IntAct11278462 20576130 25241761 details
STAT1_HUMANPIAS1_HUMANBioGRID, HPRD, IntAct10805787 11257227 12171910 12855578 17371985 18566411 25241761 9724754 details
STAT1_HUMANJAK2_HUMANBioGRID, HPRD, MINT10918587 11152457 11294897 11839738 12637327 12817007 14978237 15284024 15322115 19834108 20353823 24255956 7543024 7657660 7690989 details
STAT1_HUMANSPTB1_HUMANBioGRID, IntAct25814554 details
STAT1_HUMANIRF1_HUMANBioGRID, HPRD, IntAct, NTNU10764778 16512786 17525742 19124747 8810328 details
STAT1_HUMANOTUD4_HUMANBioGRID, IntAct25416956 details
STAT1_HUMANIMA5_HUMANBioGRID, HPRD, MINT10964507 12048190 17596301 26966684 details
STAT1_HUMANJAK1_HUMANBioGRID, HPRD, IntAct10918587 10982844 11294897 11722592 11839738 12637327 12817007 14978237 15284024 15322115 32123171 32814877 32953130 7543024 7657660 7690989 details
STAT1_HUMANLZTR1_HUMANBioGRID, IntAct20211142 details
STAT1_HUMANFANCC_HUMANBioGRID, HPRD10848598 11520787 14499622 details
STAT1_HUMANRACK1_HUMANBioGRID, HPRD11301323 12960323 details
STAT1_HUMANTYK2_HUMANBioGRID, HPRD10918587 11294897 11839738 12637327 12817007 12960323 15322115 7543024 7657660 7690989 details
STAT1_HUMANI27RA_HUMANBioGRID, HPRD12734330 details
STAT1_HUMANCBP_HUMANBioGRID, HPRD10848577 15695802 15894584 16481475 19915063 25451029 25733689 8986769 9037008 details
STAT1_HUMANE2AK2_HUMANBioGRID, HPRD11278865 9135145 details
STAT1_HUMANIL2RB_HUMANBioGRID, HPRD10602027 details
STAT1_HUMANMCM5_HUMANBioGRID, HPRD11248027 9843502 details
STAT1_HUMANVDR_HUMANBioGRID, HPRD11909970 details
STAT1_HUMANTRADD_HUMANBioGRID, HPRD10848577 details
STAT1_HUMANKPCD_HUMANBioGRID, HPRD11839738 11972023 12637327 12807916 12817007 14963018 15322115 19553685 7543024 7690989 9355737 details
STAT1_HUMANELP2_HUMANBioGRID, HPRD10954736 details
STAT1_HUMANGTF2I_HUMANBioGRID, HPRD9584171 details
STAT1_HUMANBRCA1_HUMANBioGRID, HPRD10792030 details
STAT1_HUMANATF3_HUMANBioGRID19647793 details
STAT1_HUMANDOT1L_HUMANBioGRID22002246 details
STAT1_HUMANUBC9_HUMANBioGRID, HPRD12356736 14517261 details
STAT1_HUMANANM1_HUMANBioGRID, HPRD11257227 12171910 details
STAT1_HUMANANM3_HUMANBioGRID11257227 details
STAT1_HUMANPK3CA_HUMANBioGRID11438544 details
STAT1_HUMANXPO1_HUMANBioGRID, HPRD22833565 26673895 9205132 details
STAT1_HUMANCASP3_HUMANBioGRID18723680 details
STAT1_HUMANCASP7_HUMANBioGRID18723680 details
STAT1_HUMANSTAT4_HUMANBioGRID21826217 details
STAT1_HUMANPTN11_HUMANBioGRID, HPRD12270932 27229929 details
STAT1_HUMANHSP7C_HUMANBioGRID19299420 27684187 details
STAT1_HUMANDUS2_HUMANBioGRID12270932 details
STAT1_HUMANSHPS1_HUMANBioGRID19299420 details
STAT1_HUMANFRIH_HUMANBioGRID19299420 details
STAT1_HUMANDDX6_HUMANBioGRID19299420 details
STAT1_HUMANCDC42_HUMANBioGRID31478661 details
STAT1_HUMANTP4A3_HUMANIntAct17353931 details
STAT1_HUMANUBE2F_HUMANIntAct17353931 details
STAT1_HUMANGSTK1_HUMANIntAct17353931 details
STAT1_HUMANINAR1_HUMANMINT9121453 details
STAT1_HUMANDNJA3_HUMANIntAct21106534 details
STAT1_HUMANPGFRA_HUMANBioGRID, HPRD, IntAct25241761 9484840 details
STAT1_HUMANMTOR_HUMANBioGRID, IntAct12807916 19553685 25241761 details
STAT1_HUMANFOS_HUMANBioGRID, HPRD, IntAct12788789 25241761 details
STAT1_HUMANTF65_HUMANBioGRID, HPRD, IntAct16481475 25241761 details
STAT1_HUMANSTA5A_HUMANBioGRID, HPRD, IntAct10358045 25241761 details
STAT1_HUMANCNOT7_HUMANMINT23386060 details
STAT1_HUMANPGFRB_HUMANHPRD, IntAct23397142 8549654 9484840 details
STAT1_HUMANDDX58_HUMANIntAct24360797 details
STAT1_HUMANKPCE_HUMANBioGRID, IntAct20353823 24825907 details
STAT1_HUMANKDM3A_HUMANDIP25535969 details
STAT1_HUMANIMA7_HUMANHPRD, MINT16298512 26966684 details
STAT1_HUMANEP300_HUMANBioGRID, HPRD10464260 11134049 11923478 12403783 15824515 18566411 19915063 26479788 26504087 8986769 9843502 details
STAT1_HUMANSRC_HUMANBioGRID, HPRD10358079 14978237 9344858 details
STAT1_HUMANHSF1_HUMANBioGRID, HPRD9880553 details
STAT1_HUMANTNR1A_HUMANBioGRID, HPRD10848577 details
STAT1_HUMANJUN_HUMANBioGRID, HPRD10490649 details
STAT1_HUMANRNF11_HUMANBioGRID19131965 details
STAT1_HUMANPTN2_HUMANBioGRID, HPRD12138178 12171910 14600148 19171783 details
STAT1_HUMANMBD1_HUMANBioGRID19074829 details
STAT1_HUMANBCL3_HUMANBioGRID16306601 details
STAT1_HUMANSMCA4_HUMANBioGRID16195385 20353823 21079652 details
STAT1_HUMANTIF1B_HUMANBioGRID18037959 18381204 details
STAT1_HUMANCTBL1_HUMANBioGRID21385873 details
STAT1_HUMANSMCA2_HUMANBioGRID21079652 details
STAT1_HUMANSMUF1_HUMANBioGRID22474288 details
STAT1_HUMANPRS6A_HUMANBioGRID19853614 details
STAT1_HUMANH32_HUMANBioGRID21689637 details
STAT1_HUMANHDAC4_HUMANBioGRID21571862 details
STAT1_HUMANISG15_HUMANBioGRID16009940 33024031 details
STAT1_HUMANIRAK1_HUMANBioGRID12856330 details
STAT1_HUMANIKBA_HUMANBioGRID16481475 details
STAT1_HUMANHDAC1_HUMANBioGRID16481475 details
STAT1_HUMANHDAC3_HUMANBioGRID16481475 details
STAT1_HUMANIGBP1_HUMANBioGRID19553685 details
STAT1_HUMANLST8_HUMANBioGRID19553685 details
STAT1_HUMANPTPA_HUMANBioGRID19553685 details
STAT1_HUMANKS6B1_HUMANBioGRID19553685 details
STAT1_HUMANUBP13_HUMANBioGRID23940278 details
STAT1_HUMANDTX3L_HUMANBioGRID24886089 26479788 details
STAT1_HUMANGBB2_HUMANBioGRID23326349 details
STAT1_HUMANPML_HUMANBioGRID25733689 25812002 details
STAT1_HUMANPARP9_HUMANBioGRID23487038 26479788 details
STAT1_HUMANH2B1J_HUMANBioGRID26479788 details
STAT1_HUMANPPARA_HUMANBioGRID26504087 details
STAT1_HUMANPPARD_HUMANBioGRID26504087 details
STAT1_HUMANPPARG_HUMANBioGRID26504087 details
STAT1_HUMANFANCE_HUMANBioGRID26277624 details
STAT1_HUMANU2AF2_HUMANBioGRID26641092 details
STAT1_HUMANITAV_HUMANBioGRID23640055 details
STAT1_HUMANENPL_HUMANBioGRID18662321 details
STAT1_HUMANACK1_HUMANBioGRID28739485 details
STAT1_HUMANUBP2_HUMANBioGRID27434509 details
STAT1_HUMANNR1H3_HUMANBioGRID27485016 details
STAT1_HUMANNR1H2_HUMANBioGRID27485016 details
STAT1_HUMANMAGA3_HUMANBioGRID30588194 details
STAT1_HUMANRNF31_HUMANBioGRID32123171 details
STAT1_HUMANOTUL_HUMANBioGRID32123171 details
STAT1_HUMANRN220_HUMANBioGRID32814877 details
STAT1_HUMANATG5_HUMANBioGRID33024031 details
STAT1_HUMANTNR1B_HUMANHPRD10848577 details
STAT1_HUMANBMX_HUMANHPRD9373245 details
STAT1_HUMANIL2RG_HUMANHPRD11418623 details
STAT1_HUMANXPO2_HUMANHPRD11927559 details
STAT1_HUMANKS6A5_HUMANHPRD14963018 details
STAT1_HUMANZN467_HUMANHPRD12426389 details
STAT1_HUMANMK14_HUMANHPRD11226159 details
STAT1_HUMANDUS3_HUMANHPRD11238845 details
STAT1_HUMANIL3RB_HUMANHPRD8631962 details
STAT1_HUMANMCM3_HUMANHPRD9843502 details
STAT1_HUMANKCC2D_HUMANHPRD11972023 details
STAT1_HUMANRAC1_HUMANHPRD15494521 details
STAT1_HUMANCXCR4_HUMANHPRD10506573 details
STAT1_HUMANVGFR2_HUMANHPRD10961983 details
STAT1_HUMANVGFR1_HUMANHPRD15703780 details
STAT1_HUMANCCR1_HUMANHPRD14674010 details
STAT1_HUMANCCR5_HUMANHPRD14674010 details
STAT1_HUMANFYN_HUMANHPRD9804857 details
STAT1_HUMANIRF2_HUMANHPRD15778351 details
STAT1_HUMANAKT1_HUMANHPRD15284024 details
STAT1_HUMANFADD_HUMANHPRD10848577 details
STAT1_HUMANSTA5B_HUMANHPRD10358045 details
STAT1_HUMANKSYK_HUMANHPRD15467722 details
STAT1_HUMANSUMO4_HUMANHPRD16236267 details
STAT1_HUMANFGFR3_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1_HUMANFGFR4_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1_HUMANADA1B_HUMANHPRD10652206 details
STAT1_HUMANLCK_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
STAT1_HUMANMK_HUMANHPRD9452495 details