Entity Details

Primary name WASP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42768
EntryNameWASP_HUMAN
FullNameWiskott-Aldrich syndrome protein
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesWAS

GO terms

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GOName
GO:0002625 regulation of T cell antigen processing and presentation
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006952 defense response
GO:0006955 immune response
GO:0007596 blood coagulation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0008544 epidermis development
GO:0010591 regulation of lamellipodium assembly
GO:0012506 vesicle membrane
GO:0015629 actin cytoskeleton
GO:0016197 endosomal transport
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0030041 actin filament polymerization
GO:0030048 actin filament-based movement
GO:0030695 GTPase regulator activity
GO:0031267 small GTPase binding
GO:0032488 Cdc42 protein signal transduction
GO:0035861 site of double-strand break
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042110 T cell activation
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0045335 phagocytic vesicle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050852 T cell receptor signaling pathway
GO:0051492 regulation of stress fiber assembly
GO:0051497 negative regulation of stress fiber assembly
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0071346 cellular response to interferon-gamma
GO:1905168 positive regulation of double-strand break repair via homologous recombination
GO:2000146 negative regulation of cell motility
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000697 WH1/EVH1 domainDomainDomain
IPR003124 WH2 domainDomainDomain
IPR011026 Wiscott-Aldrich syndrome protein, C-terminalFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR027641 Wiskott-Aldrich syndrome proteinFamilyFamily
IPR033927 WASP family, EVH1 domainDomainDomain
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
301000 OMIMWiskott-Aldrich syndrome (WAS)An X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10. The disease is caused by variants affecting the gene represented in this entry.
313900 OMIMThrombocytopenia 1 (THC1)A form of thrombocytopenia, a hematologic disorder defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. The disease is caused by variants affecting the gene represented in this entry.
300299 OMIMNeutropenia, severe congenital, X-linked (XLN)A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01731 (S)-wiskostatinDrugbanksmall molecule

Interactions

85 interactions

InteractorPartnerSourcesPublicationsLink
WASP_HUMANCDC42_HUMANBioGRID, DIP, HPRD, IntAct, mbinfo, MINT10068673 10360578 10360579 10684602 10713100 10724160 10802735 12235133 12769846 15075243 15361624 20936779 22252508 25502805 28539360 31515488 8625410 8643625 9422512 9660763 9742969 details
WASP_HUMANFGR_HUMANBioGRID, HPRD, MINT10358777 7565724 8805332 8824280 details
WASP_HUMANNCK1_HUMANBioGRID, HPRD, MINT10747096 11340081 12135674 24287595 7565724 details
WASP_HUMANFYN_HUMANBioGRID, HPRD, MINT10224664 10532312 12431372 14707117 7565724 8805332 details
WASP_HUMANARC1B_HUMANHPRD, mbinfo, MINT10861055 11943145 details
WASP_HUMANHCK_HUMANBioGRID, HPRD, mbinfo, MINT10068673 12029088 12235133 12769846 19234535 9742969 details
WASP_HUMANPPIP1_HUMANBioGRID, HPRD, MINT14707117 19041431 9488710 details
WASP_HUMANPTN12_HUMANHPRD, IntAct, MINT11711533 14707117 15588985 19167335 details
WASP_HUMANWASP_HUMANDIP, HPRD, IntAct10724160 12769847 18650809 details
WASP_HUMANCSK21_HUMANBioGRID, HPRD, IntAct12769847 details
WASP_HUMANARPC3_HUMANBioGRID, IntAct12769847 23148219 9889097 details
WASP_HUMANWIPF1_HUMANBioGRID, DIP, HPRD, IntAct, mbinfo10202051 12591280 16055720 16488394 17213309 19805221 19817875 21988832 25416956 32296183 9405671 9694849 details
WASP_HUMANGAS7_HUMANBioGRID, MINT16055720 26506240 details
WASP_HUMANWBP4_HUMANBioGRID, MINT16055720 details
WASP_HUMANPTPRC_HUMANIntAct19167335 details
WASP_HUMANPTPRG_HUMANIntAct19167335 details
WASP_HUMANPTPRZ_HUMANIntAct19167335 details
WASP_HUMANPTPRB_HUMANIntAct19167335 details
WASP_HUMANPTPRJ_HUMANIntAct19167335 details
WASP_HUMANPTPRO_HUMANIntAct19167335 details
WASP_HUMANPTN22_HUMANIntAct19167335 details
WASP_HUMANLCK_HUMANBioGRID, MINT16107303 16293614 details
WASP_HUMANSNX9_HUMANBioGRID, DIP, MINT17242350 19487689 details
WASP_HUMANDVL2_HUMANBioGRID, MINT21516116 details
WASP_HUMANABI3_HUMANBioGRID, IntAct, MINT21516116 25416956 details
WASP_HUMANFCSD2_HUMANBioGRID, IntAct21988832 details
WASP_HUMANRGS14_HUMANBioGRID, IntAct21988832 details
WASP_HUMANWIPF2_HUMANBioGRID, HPRD, IntAct12213210 16055720 21988832 details
WASP_HUMANRHOJ_HUMANBioGRID, HPRD, mbinfo10967094 14521508 details
WASP_HUMANROBO4_HUMANmbinfo18948384 details
WASP_HUMANBTK_HUMANbhf-ucl, BioGRID, HPRD10068673 10427990 12235133 12769846 8892607 9742969 details
WASP_HUMANPLCG1_HUMANbhf-ucl, BioGRID, HPRD8805332 8824280 8892607 details
WASP_HUMANITK_HUMANbhf-ucl, BioGRID, HPRD8810341 8892607 details
WASP_HUMANTEC_HUMANbhf-ucl, BioGRID, HPRD8892607 details
WASP_HUMANGRB2_HUMANbhf-ucl, BioGRID, HPRD10224664 8805332 8892607 9307968 details
WASP_HUMANNCK2_HUMANBioGRID, IntAct24287595 25416956 details
WASP_HUMANSRBS2_HUMANBioGRID, IntAct25416956 details
WASP_HUMANAPBP2_HUMANBioGRID, IntAct25416956 details
WASP_HUMANUBS3A_HUMANBioGRID, IntAct32296183 details
WASP_HUMANCIP4_HUMANBioGRID, HPRD10713100 21516116 details
WASP_HUMANP85A_HUMANBioGRID, HPRD10358777 17242350 8805332 details
WASP_HUMANSRC_HUMANBioGRID, HPRD8805332 8824280 details
WASP_HUMANCRKL_HUMANBioGRID, HPRD11313252 details
WASP_HUMANVASP_HUMANBioGRID, HPRD11598004 16055720 details
WASP_HUMANRAC1_HUMANBioGRID, HPRD8643625 details
WASP_HUMANITSN2_HUMANBioGRID, HPRD11748279 22558309 details
WASP_HUMANACK1_HUMANBioGRID16257963 details
WASP_HUMANARPC2_HUMANBioGRID11943145 details
WASP_HUMANBI2L1_HUMANBioGRID22921828 details
WASP_HUMANTCRG1_HUMANBioGRID16055720 details
WASP_HUMANPR40A_HUMANBioGRID16055720 details
WASP_HUMANAPBB1_HUMANBioGRID16055720 details
WASP_HUMANRBP2_HUMANBioGRID26261240 details
WASP_HUMANC5AR1_HUMANBioGRID, HPRD12600272 details
WASP_HUMANCBP_HUMANBioGRID32238831 details
WASP_HUMANRHG01_HUMANHPRD8805223 details
WASP_HUMANCIB1_HUMANHPRD16582881 details
WASP_HUMANSNX33_HUMANMINT19487689 details
WASP_HUMANSRC8_HUMANmbinfo15169891 details
WASP_HUMANRAC2_HUMANmbinfo14521508 details
WASP_HUMANRAC3_HUMANmbinfo14521508 details
WASP_HUMANRHOQ_HUMANmbinfo14521508 details
WASP_HUMANHCLS1_HUMANHPRD, mbinfo15166239 21398607 details
WASP_HUMANEGFR_HUMANBioGRID9307968 details
WASP_HUMANFYB1_HUMANBioGRID, HPRD10747096 details
WASP_HUMANLCP2_HUMANBioGRID, HPRD10747096 details
WASP_HUMANPACN1_HUMANBioGRID19041431 details
WASP_HUMANPACN2_HUMANBioGRID19041431 details
WASP_HUMANPACN3_HUMANBioGRID19041431 details
WASP_HUMANFNBP1_HUMANBioGRID16418535 19041431 details
WASP_HUMANSRGP2_HUMANBioGRID19041431 details
WASP_HUMANRBBP5_HUMANBioGRID20574068 details
WASP_HUMANJMJD6_HUMANBioGRID20574068 details
WASP_HUMANKDM4A_HUMANBioGRID20574068 details
WASP_HUMANKDM6B_HUMANBioGRID20574068 details
WASP_HUMANITSN1_HUMANBioGRID15824104 18539136 details
WASP_HUMANCBL_HUMANBioGRID23684068 details
WASP_HUMANCBLB_HUMANBioGRID23684068 details
WASP_HUMANCSK22_HUMANHPRD12769847 details
WASP_HUMANACTC_HUMANHPRD12029088 details
WASP_HUMANDLG1_HUMANHPRD15699074 details
WASP_HUMANSPN90_HUMANHPRD14559906 details
WASP_HUMANARHG7_HUMANHPRD14559906 details
WASP_HUMANEVL_HUMANHPRD16055720 details
WASP_HUMANENAH_HUMANHPRD16055720 details