Entity Details

Primary name NAL12_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP59046
EntryNameNAL12_HUMAN
FullNameNACHT, LRR and PYD domains-containing protein 12
TaxID9606
Evidenceevidence at protein level
Length1061
SequenceStatuscomplete
DateCreated2002-10-19
DateModified2021-06-02

Ontological Relatives

GenesNLRP12

GO terms

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GOName
GO:0001818 negative regulation of cytokine production
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0009968 negative regulation of signal transduction
GO:0031953 negative regulation of protein autophosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032661 regulation of interleukin-18 production
GO:0032692 negative regulation of interleukin-1 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045345 positive regulation of MHC class I biosynthetic process
GO:0045751 negative regulation of Toll signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0071345 cellular response to cytokine stimulus
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR004020 DAPIN domainDomainDomain
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029495 NACHT-associated domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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Disease IDSourceNameDescription
611762 OMIMFamilial cold autoinflammatory syndrome 2 (FCAS2)A rare autosomal dominant systemic inflammatory disease characterized by recurrent episodes of maculopapular rash associated with arthralgias, myalgias, fever and chills, swelling of the extremities, and conjunctivitis after generalized exposure to cold. The disease is caused by variants affecting the gene represented in this entry.

Interactions

71 interactions

InteractorPartnerSourcesPublicationsLink
NAL12_HUMANPYDC2_HUMANUniProt17178784 details
NAL12_HUMANFLNA_HUMANI2D32226298 details
NAL12_HUMANMT2_HUMANI2D32226298 details
NAL12_HUMANDAZP2_HUMANI2D32226298 details
NAL12_HUMANDNJB1_HUMANI2D32226298 details
NAL12_HUMANCD14_HUMANI2D32226298 details
NAL12_HUMANDDX5_HUMANI2D32226298 details
NAL12_HUMANTLN1_HUMANI2D32226298 details
NAL12_HUMANCAMLG_HUMANI2D32226298 details
NAL12_HUMANSNUT1_HUMANI2D32226298 details
NAL12_HUMANRANB9_HUMANI2D32226298 details
NAL12_HUMANT3JAM_HUMANI2D32226298 details
NAL12_HUMANTRIP4_HUMANI2D32226298 details
NAL12_HUMANRS20_HUMANI2D32226298 details
NAL12_HUMANCOR1A_HUMANI2D32226298 details
NAL12_HUMANGLNA_HUMANI2D32226298 details
NAL12_HUMANACTB_HUMANI2D32226298 details
NAL12_HUMANWAC_HUMANI2D32226298 details
NAL12_HUMANRNC_HUMANI2D32226298 details
NAL12_HUMANDNJA3_HUMANI2D32226298 details
NAL12_HUMANPTPRE_HUMANI2D32226298 details
NAL12_HUMANUBQL1_HUMANI2D32226298 details
NAL12_HUMANBIRC3_HUMANI2D32226298 details
NAL12_HUMANTNR6C_HUMANI2D32226298 details
NAL12_HUMANPPBT_HUMANI2D32226298 details
NAL12_HUMANPRP6_HUMANI2D32226298 details
NAL12_HUMANUBX2B_HUMANI2D32226298 details
NAL12_HUMANBAG6_HUMANI2D32226298 details
NAL12_HUMANSCTM1_HUMANI2D32226298 details
NAL12_HUMANSAT2_HUMANI2D32226298 details
NAL12_HUMANZN426_HUMANI2D32226298 details
NAL12_HUMANHLAB_HUMANI2D32226298 details
NAL12_HUMANFBN2_HUMANI2D32226298 details
NAL12_HUMAN3BP2_HUMANI2D32226298 details
NAL12_HUMANMYO1F_HUMANI2D32226298 details
NAL12_HUMANFRIH_HUMANI2D32226298 details
NAL12_HUMANLRC42_HUMANI2D32226298 details
NAL12_HUMANURP2_HUMANI2D32226298 details
NAL12_HUMANLEG9B_HUMANI2D32226298 details
NAL12_HUMANSODM_HUMANI2D32226298 details
NAL12_HUMANCHSTF_HUMANI2D32226298 details
NAL12_HUMANHAX1_HUMANI2D32226298 details
NAL12_HUMANHLAC_HUMANI2D32226298 details
NAL12_HUMANAK17A_HUMANI2D32226298 details
NAL12_HUMANIL8_HUMANI2D32226298 details
NAL12_HUMANHCK_HUMANI2D32226298 details
NAL12_HUMANCAP1_HUMANI2D32226298 details
NAL12_HUMANAKIP1_HUMANI2D32226298 details
NAL12_HUMANUBQL2_HUMANI2D32226298 details
NAL12_HUMANFAF1_HUMANBioGRID17046979 details
NAL12_HUMANFKBP5_HUMANIntAct25036637 details
NAL12_HUMANMLF1_HUMANIntAct25036637 details
NAL12_HUMANMLF2_HUMANIntAct25036637 details
NAL12_HUMANHSF2_HUMANIntAct25036637 details
NAL12_HUMANNUDC3_HUMANIntAct25036637 details
NAL12_HUMANSGTA_HUMANIntAct25036637 details
NAL12_HUMANPSMD2_HUMANIntAct25036637 details
NAL12_HUMANFKBPL_HUMANIntAct25036637 details
NAL12_HUMANSTIP1_HUMANIntAct25036637 details
NAL12_HUMANHS90A_HUMANBioGRID, IntAct17947705 25036637 details
NAL12_HUMANPTG3L_HUMANIntAct25036637 details
NAL12_HUMANAASD1_HUMANIntAct25036637 details
NAL12_HUMANCYBP_HUMANIntAct25036637 details
NAL12_HUMANCHIP_HUMANIntAct25036637 details
NAL12_HUMANCDC37_HUMANIntAct25036637 details
NAL12_HUMANTTC1_HUMANIntAct25036637 details
NAL12_HUMANIRAK1_HUMANBioGRID, HPRD16203735 details
NAL12_HUMANHSP74_HUMANBioGRID17947705 details
NAL12_HUMANHSP7C_HUMANBioGRID17947705 details
NAL12_HUMANTRI25_HUMANBioGRID30902577 details
NAL12_HUMANASC_HUMANHPRD12019269 details