Entity Details

Primary name SNP25_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP60880
EntryNameSNP25_HUMAN
FullNameSynaptosomal-associated protein 25
TaxID9606
Evidenceevidence at protein level
Length206
SequenceStatuscomplete
DateCreated2004-04-13
DateModified2021-06-02

Ontological Relatives

GenesSNAP25

GO terms

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GOName
GO:0001504 neurotransmitter uptake
GO:0001917 photoreceptor inner segment
GO:0005249 voltage-gated potassium channel activity
GO:0005484 SNAP receptor activity
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0006906 vesicle fusion
GO:0007268 chemical synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007626 locomotory behavior
GO:0008021 synaptic vesicle
GO:0008306 associative learning
GO:0010975 regulation of neuron projection development
GO:0016020 membrane
GO:0016079 synaptic vesicle exocytosis
GO:0016081 synaptic vesicle docking
GO:0016082 synaptic vesicle priming
GO:0017075 syntaxin-1 binding
GO:0019905 syntaxin binding
GO:0030426 growth cone
GO:0031201 SNARE complex
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane
GO:0035579 specific granule membrane
GO:0036477 somatodendritic compartment
GO:0042734 presynaptic membrane
GO:0043005 neuron projection
GO:0043312 neutrophil degranulation
GO:0048306 calcium-dependent protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0050796 regulation of insulin secretion
GO:0060291 long-term synaptic potentiation
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070821 tertiary granule membrane
GO:0098794 postsynapse
GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane
GO:0098978 glutamatergic synapse
GO:0099590 neurotransmitter receptor internalization

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Photoreceptor inner segment

Domains

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DomainNameCategoryType
IPR000727 Target SNARE coiled-coil homology domainDomainDomain
IPR000928 SNAP-25 domainDomainDomain
IPR039077 Synaptosomal-associated protein 25FamilyFamily

Diseases

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Disease IDSourceNameDescription
616330 OMIMMyasthenic syndrome, congenital, 18 (CMS18)A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS18 is an autosomal dominant presynaptic disorder clinically characterized by early-onset muscle weakness and easy fatigability associated with delayed psychomotor development and ataxia. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00083 Botulinum toxin type ADrugbankbiotech

Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
SNP25_HUMANZDH17_HUMANHPRD, IntAct15603740 details
SNP25_HUMANSTX1A_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10195194 10373452 10449403 10954418 11509230 11524423 11832227 16169070 17363971 20489724 20798282 30610939 7553862 7622514 7768895 7961655 8663154 9556632 9852078 details
SNP25_HUMANSTX11_HUMANBioGRID, HPRD, IntAct16169070 16189514 32296183 details
SNP25_HUMANITSN1_HUMANBioGRID, HPRD, MINT10373452 16874303 details
SNP25_HUMANSTX19_HUMANBioGRID, IntAct32296183 details
SNP25_HUMANCPLX1_HUMANBioGRID, DIP11832227 12200427 21785412 21785414 details
SNP25_HUMANEGFR_HUMANIntAct20029029 31980649 details
SNP25_HUMANPRRT2_HUMANBioGRID, HPRD, IntAct16169070 details
SNP25_HUMANSYT1_HUMANBioGRID, HPRD, MINT10692432 12062043 22890573 30610939 details
SNP25_HUMANZN177_HUMANBioGRID, IntAct32296183 details
SNP25_HUMANVAMP7_HUMANBioGRID, HPRD12853575 details
SNP25_HUMANUQCC2_HUMANBioGRID, IntAct32296183 details
SNP25_HUMANKINH_HUMANBioGRID, HPRD12475239 details
SNP25_HUMANWASC3_HUMANBioGRID, IntAct19060904 details
SNP25_HUMANHD_HUMANIntAct17500595 32814053 details
SNP25_HUMANSYT3_HUMANBioGRID, HPRD10692432 details
SNP25_HUMANVAMP2_HUMANBioGRID, DIP, HPRD, MINT, UniProt11524423 11832227 20798282 21785412 21785414 22890573 30610939 7961655 9030619 details
SNP25_HUMANSNAPN_HUMANBioGRID, HPRD10195194 22890573 details
SNP25_HUMANSTX3_HUMANBioGRID, HPRD7768895 8663154 9852078 details
SNP25_HUMANSNAA_HUMANBioGRID7622514 details
SNP25_HUMANHGS_HUMANBioGRID, HPRD10825299 12847087 details
SNP25_HUMANGOSR1_HUMANBioGRID9325254 details
SNP25_HUMANA4_HUMANBioGRID21832049 details
SNP25_HUMANSRCN1_HUMANBioGRID, HPRD10625663 details
SNP25_HUMANSTX4_HUMANBioGRID, HPRD10194441 8663154 8760387 9168999 9852078 details
SNP25_HUMANSCAM1_HUMANBioGRID10777571 details
SNP25_HUMANSTX5_HUMANBioGRID9325254 details
SNP25_HUMANKCNB1_HUMANBioGRID, HPRD12403834 details
SNP25_HUMANTRIM9_HUMANBioGRID, HPRD11524423 24778312 details
SNP25_HUMANSTX2_HUMANBioGRID, HPRD7768895 8663154 details
SNP25_HUMANFBX7_HUMANBioGRID27503909 details
SNP25_HUMANCENPF_HUMANHPRD16672379 details
SNP25_HUMANRP3A_HUMANBioGRID29367474 details
SNP25_HUMANARF1_HUMANMINT30610939 details
SNP25_HUMANSTX12_HUMANBioGRID, HPRD, MINT10886332 30610939 details
SNP25_HUMANUN13B_HUMANBioGRID8999968 details
SNP25_HUMANKAPCA_HUMANHPRD12459461 details
SNP25_HUMANKPCA_HUMANHPRD12459461 details
SNP25_HUMANSYT9_HUMANHPRD12062043 details
SNP25_HUMANVAMP8_HUMANHPRD10336434 details
SNP25_HUMANRIMS1_HUMANHPRD11438521 details
SNP25_HUMANDYN1_HUMANHPRD10373452 details
SNP25_HUMANSTXB6_HUMANHPRD12145319 details