Entity Details

Primary name STX1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61266
EntryNameSTX1B_HUMAN
FullNameSyntaxin-1B
TaxID9606
Evidenceevidence at protein level
Length288
SequenceStatuscomplete
DateCreated2004-05-10
DateModified2021-06-02

Ontological Relatives

GenesSTX1B

GO terms

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GOName
GO:0000149 SNARE binding
GO:0001956 positive regulation of neurotransmitter secretion
GO:0005102 signaling receptor binding
GO:0005484 SNAP receptor activity
GO:0005634 nucleus
GO:0005652 nuclear lamina
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006886 intracellular protein transport
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0006906 vesicle fusion
GO:0008021 synaptic vesicle
GO:0010468 regulation of gene expression
GO:0010807 regulation of synaptic vesicle priming
GO:0010977 negative regulation of neuron projection development
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016081 synaptic vesicle docking
GO:0017157 regulation of exocytosis
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030424 axon
GO:0031201 SNARE complex
GO:0031594 neuromuscular junction
GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane
GO:0048278 vesicle docking
GO:0048787 presynaptic active zone membrane
GO:0048791 calcium ion-regulated exocytosis of neurotransmitter
GO:0060025 regulation of synaptic activity
GO:0061669 spontaneous neurotransmitter secretion
GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane
GO:1903422 negative regulation of synaptic vesicle recycling
GO:1904050 positive regulation of spontaneous neurotransmitter secretion
GO:1905302 negative regulation of macropinocytosis
GO:2000463 positive regulation of excitatory postsynaptic potential

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000727 Target SNARE coiled-coil homology domainDomainDomain
IPR006011 Syntaxin, N-terminal domainDomainDomain
IPR006012 Syntaxin/epimorphin, conserved siteSiteConserved site
IPR010989 SNAREFamilyHomologous superfamily
IPR028669 Syntaxin 1FamilyFamily

Diseases

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Disease IDSourceNameDescription
616172 OMIMGeneralized epilepsy with febrile seizures plus 9 (GEFSP9)An autosomal dominant neurologic disorder characterized by febrile and/or afebrile seizures manifesting in early childhood. Seizure are variable and include generalized tonic-clonic, atonic, myoclonic, complex partial, and absence types. Most patients have remission of seizures later in childhood with no residual neurologic deficits. Rarely, patients may show mild developmental delay or mild intellectual disabilities. The disease is caused by variants affecting the gene represented in this entry.

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
STX1B_HUMANSNP23_HUMANBioGRID, IntAct12651853 26359495 details
STX1B_HUMANSNP47_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANSNAB_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANTXLNA_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANVAMP5_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANBET1_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANSTX2_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANVAMP1_HUMANBioGRID, HPRD, IntAct12093152 32296183 details
STX1B_HUMANF161B_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANACBD5_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANFA81A_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANKCNN4_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANEMC5_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANGP152_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANEBP_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANSTX4_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANSNP29_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANVAMP2_HUMANBioGRID, HPRD, IntAct12093152 32296183 details
STX1B_HUMANFBX28_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANABHGA_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANCXA8_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANKISHB_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANFIBA_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANF209A_HUMANBioGRID, IntAct32296183 details
STX1B_HUMANSTXB1_HUMANBioGRID, HPRD, IntAct12093152 31413325 details
STX1B_HUMANUN13B_HUMANBioGRID, HPRD8999968 details
STX1B_HUMANVAPB_HUMANBioGRID12651853 24885147 details
STX1B_HUMANUBC9_HUMANBioGRID32296183 details
STX1B_HUMANDISC1_HUMANIntAct31413325 details
STX1B_HUMANVAMP8_HUMANHPRD11112705 details