Entity Details

Primary name TAP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03518
EntryNameTAP1_HUMAN
FullNameAntigen peptide transporter 1
TaxID9606
Evidenceevidence at protein level
Length808
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesTAP1

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005524 ATP binding
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006952 defense response
GO:0015031 protein transport
GO:0015433 ABC-type peptide antigen transporter activity
GO:0015440 ABC-type peptide transporter activity
GO:0015833 peptide transport
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0023029 MHC class Ib protein binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030670 phagocytic vesicle membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0034451 centriolar satellite
GO:0042288 MHC class I protein binding
GO:0042605 peptide antigen binding
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042803 protein homodimerization activity
GO:0042824 MHC class I peptide loading complex
GO:0042825 TAP complex
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0046967 cytosol to endoplasmic reticulum transport
GO:0046978 TAP1 binding
GO:0046979 TAP2 binding
GO:0055085 transmembrane transport
GO:1904680 peptide transmembrane transporter activity
GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR013305 ABC transporter Tap-likeFamilyFamily
IPR013306 Antigen peptide transporter 1FamilyFamily
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily
IPR039421 Type 1 protein exporterFamilyFamily

Diseases

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Disease IDSourceNameDescription
604571 OMIMBare lymphocyte syndrome 1 (BLS1)A HLA class I deficiency. Contrary to bare lymphocyte syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life. Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of life, are restricted to the respiratory tract. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB01259 LapatinibDrugbanksmall molecule

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
TAP1_HUMANKR412_HUMANBioGRID, HPRD, IntAct16189514 details
TAP1_HUMANMDFI_HUMANBioGRID, HPRD, IntAct16189514 details
TAP1_HUMANPSB9_HUMANIntAct15488952 details
TAP1_HUMANPSB8_HUMANBioGRID, HPRD, IntAct15488952 details
TAP1_HUMANTPSN_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt11823531 11884415 12213826 16828748 17055437 18802093 19201886 details
TAP1_HUMANTAP2_HUMANBioGRID, DIP, HPIDb, HPRD, IntAct, MINT, UniProt11133832 11381133 12213826 16828748 17055437 18802093 19201886 19297616 26789246 28514442 30833792 details
TAP1_HUMANTHOC5_HUMANMINT19165146 details
TAP1_HUMANNUP42_HUMANMINT19165146 details
TAP1_HUMANCREB3_HUMANBioGRID, MINT21516116 details
TAP1_HUMANTYDP2_HUMANBioGRID, IntAct21988832 details
TAP1_HUMANMUL1_HUMANBioGRID, IntAct21988832 details
TAP1_HUMANGEMI4_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANTM14B_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANSOAT_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANRN19B_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANERGI3_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANSSMM1_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANGP152_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANNTCP_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANSYCY2_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANLCE2C_HUMANBioGRID, IntAct32296183 details
TAP1_HUMANTAP1_HUMANDIP19297616 details
TAP1_HUMANACM3_HUMANBioGRID, MINT28298427 details
TAP1_HUMANLMNA_HUMANBioGRID24623722 details
TAP1_HUMANPSB5_HUMANHPRD15488952 details
TAP1_HUMANPDIA3_HUMANBioGRID, HPRD, IntAct11823531 17055437 30833792 9545232 details
TAP1_HUMANCALR_HUMANBioGRID, IntAct11823531 17055437 details
TAP1_HUMANPDIA1_HUMANIntAct17055437 details
TAP1_HUMANCALX_HUMANBioGRID, IntAct11823531 30833792 details
TAP1_HUMANHLAG_HUMANBioGRID, HPRD9103419 details
TAP1_HUMANCOPB_HUMANBioGRID11884415 details
TAP1_HUMANCOPG1_HUMANBioGRID11884415 details
TAP1_HUMANHLAA_HUMANBioGRID11884415 17055437 details
TAP1_HUMANPDIA2_HUMANBioGRID17055437 details
TAP1_HUMANHLAB_HUMANBioGRID11823531 details
TAP1_HUMANATG5_HUMANBioGRID33024031 details
TAP1_HUMANISG15_HUMANBioGRID33024031 details
TAP1_HUMANESR1_HUMANHPRD9774463 details
TAP1_HUMANHLAF_HUMANHPRD11169396 details