Entity Details

Primary name TRAF3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13114
EntryNameTRAF3_HUMAN
FullNameTNF receptor-associated factor 3
TaxID9606
Evidenceevidence at protein level
Length568
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesTRAF3

GO terms

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GOName
GO:0001817 regulation of cytokine production
GO:0002224 toll-like receptor signaling pathway
GO:0004842 ubiquitin-protein transferase activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008063 Toll signaling pathway
GO:0008270 zinc ion binding
GO:0009898 cytoplasmic side of plasma membrane
GO:0016579 protein deubiquitination
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030162 regulation of proteolysis
GO:0031625 ubiquitin protein ligase binding
GO:0031996 thioesterase binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032648 regulation of interferon-beta production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0046330 positive regulation of JNK cascade
GO:0050688 regulation of defense response to virus
GO:0070534 protein K63-linked ubiquitination

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome
Mitochondrion

Domains

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DomainNameCategoryType
IPR001293 Zinc finger, TRAF-typeDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR002083 MATH/TRAF domainDomainDomain
IPR008974 TRAF-likeFamilyHomologous superfamily
IPR012227 TNF receptor-associated factor TRAF, metazoaFamilyFamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027128 TNF receptor-associated factor 3FamilyFamily
IPR037304 TRAF3, MATH domainDomainDomain
IPR043211 TNF receptor-associated factor TRAFFamilyFamily

Diseases

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Disease IDSourceNameDescription
614849 OMIMEncephalopathy, acute, infection-induced, Herpes-specific, 5 (IIAE5)A rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. It is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

152 interactions

InteractorPartnerSourcesPublicationsLink
TRAF3_HUMANTRADD_HUMANBioGRID, HPRD, IntAct, MINT30561431 8565075 details
TRAF3_HUMANRIPK1_HUMANBioGRID, HPRD, IntAct, MINT32296183 8612133 details
TRAF3_HUMANM3K14_HUMANBioGRID, HPRD, IntAct11278268 14743216 15084608 15208311 18997792 18997794 20348096 23543740 25246529 28514442 30833792 31980649 32296183 33198776 9275204 details
TRAF3_HUMANTANK_HUMANBioGRID, HPRD, IntAct12005438 14517219 14743216 17823124 21903422 22079989 26779844 30561431 8710854 details
TRAF3_HUMANTNR14_HUMANBioGRID, HPRD, IntAct9162022 details
TRAF3_HUMANTNR5_HUMANBioGRID, HPRD, IntAct10352240 10984535 11562359 12220533 12637493 14517219 16260598 17878343 19667091 20614026 21041727 24260396 24810049 26779844 27716849 32041822 7527023 7530216 7533327 7859281 9168896 9384571 9718306 9990007 details
TRAF3_HUMANMIPT3_HUMANBioGRID, HPRD, UniProt10791955 22079989 details
TRAF3_HUMANZMY11_HUMANBioGRID, MINT20138174 details
TRAF3_HUMANIL15_HUMANBioGRID, IntAct21988832 details
TRAF3_HUMANSAR1A_HUMANBioGRID, IntAct21988832 details
TRAF3_HUMANDAXX_HUMANBioGRID, IntAct21988832 details
TRAF3_HUMANEWS_HUMANBioGRID, IntAct21988832 details
TRAF3_HUMANMRP1_HUMANBioGRID, IntAct21988832 details
TRAF3_HUMANABC3C_HUMANBioGRID, IntAct21988832 details
TRAF3_HUMANTNR3_HUMANBioGRID, HPRD, IntAct12571250 14517219 20348096 20732415 26186194 28514442 7859281 9122217 9162022 9388227 details
TRAF3_HUMANTRAF5_HUMANBioGRID, HPRD, IntAct15383523 21903422 25241761 32296183 9718306 details
TRAF3_HUMANBIRC3_HUMANBioGRID, MINT20097753 23524849 23612708 details
TRAF3_HUMANRIPK2_HUMANBioGRID, I2D23333941 details
TRAF3_HUMANTRAF3_HUMANBioGRID, HPRD, IntAct10781837 14517219 15383523 32296183 7533327 9122217 9388227 9718306 details
TRAF3_HUMANASCC1_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANBIVM_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANRIPP1_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANPSB8_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANGMEB2_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANIFT25_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANCJ062_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANCDC37_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANZSCA4_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANIP6K3_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANCCD13_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANPIAS2_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANNTAQ1_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANCC184_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANZBT49_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANP121A_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANRD23A_HUMANBioGRID, IntAct32296183 details
TRAF3_HUMANSNP29_HUMANBioGRID, IntAct22792062 26186194 28514442 32296183 details
TRAF3_HUMANTNR8_HUMANBioGRID, HPRD, IntAct28514442 8662842 8943059 9168896 details
TRAF3_HUMANMAVS_HUMANBioGRID, DIP16858409 19419966 19893624 20080758 21200404 22022264 22079989 22792062 22901541 22908223 23545497 24622840 26221961 26519536 27348524 27980081 29125880 30267576 30527812 31390091 31806368 32324863 32366851 32511263 33411856 details
TRAF3_HUMANTBK1_HUMANBioGRID, HPRD, IntAct17991829 20174559 22079989 22330071 22792062 22908223 23308279 23717208 23986588 24622840 24763515 26928339 27135603 28049150 29125880 29920243 31404116 32324863 32779804 33372174 33411856 details
TRAF3_HUMANTRAF2_HUMANBioGRID, IntAct15383523 21903422 30561431 9718306 details
TRAF3_HUMANT3JAM_HUMANBioGRID, HPRD, MINT14572659 31390091 32366851 details
TRAF3_HUMANGMEB1_HUMANUniProt32514408 details
TRAF3_HUMANCASP3_HUMANBioGRID, HPRD11098060 11261798 details
TRAF3_HUMANTNR9_HUMANBioGRID, HPRD15941918 9464265 details
TRAF3_HUMANTNR18_HUMANBioGRID, HPRD10037686 15944293 details
TRAF3_HUMANTNR11_HUMANBioGRID, HPRD10025951 9774460 9852070 details
TRAF3_HUMANNUP62_HUMANBioGRID, HPRD10781837 details
TRAF3_HUMANTRI37_HUMANBioGRID, HPRD11279055 details
TRAF3_HUMANUBP7_HUMANBioGRID, HPRD11279055 31666375 details
TRAF3_HUMANRN216_HUMANBioGRID19893624 27026194 details
TRAF3_HUMANZBP1_HUMANBioGRID21903422 details
TRAF3_HUMANIRF1_HUMANBioGRID21903422 details
TRAF3_HUMANAZI2_HUMANBioGRID21903422 details
TRAF3_HUMANTNR1B_HUMANBioGRID, HPRD7859281 details
TRAF3_HUMANTNR1A_HUMANBioGRID7859281 details
TRAF3_HUMANTNR6_HUMANBioGRID7859281 details
TRAF3_HUMANPDLI7_HUMANBioGRID21864338 details
TRAF3_HUMANTR13C_HUMANBioGRID, HPRD12471121 15585864 21041452 details
TRAF3_HUMANTNR4_HUMANBioGRID, HPRD15941918 9418902 details
TRAF3_HUMANUBC9_HUMANBioGRID24260396 32296183 details
TRAF3_HUMANM3K7_HUMANBioGRID26882989 details
TRAF3_HUMANKC1E_HUMANBioGRID26928339 32779804 details
TRAF3_HUMANDDX3X_HUMANBioGRID27980081 details
TRAF3_HUMANSTK38_HUMANBioGRID28219902 details
TRAF3_HUMANPDZD4_HUMANBioGRID32296183 details
TRAF3_HUMANHEMGN_HUMANBioGRID32296183 details
TRAF3_HUMANTIF1A_HUMANBioGRID32324863 details
TRAF3_HUMANPTN6_HUMANBioGRID32779804 details
TRAF3_HUMANTNR12_HUMANHPRD11728344 details
TRAF3_HUMANTNR27_HUMANBioGRID, HPRD, IntAct12270937 15280356 26186194 28514442 details
TRAF3_HUMANEDAR_HUMANHPRD, IntAct11035039 details
TRAF3_HUMANPPBT_HUMANHPRD, MINT15208311 details
TRAF3_HUMANUSO1_HUMANBioGRID, IntAct21903422 22792062 details
TRAF3_HUMANBRAF_HUMANIntAct23153539 details
TRAF3_HUMANBIRC2_HUMANBioGRID, IntAct, MINT20097753 23524849 30561431 details
TRAF3_HUMANPTN22_HUMANIntAct23871208 details
TRAF3_HUMANWDR5_HUMANBioGRID, DIP20080758 details
TRAF3_HUMANMALT1_HUMANIntAct19917778 details
TRAF3_HUMANDISC1_HUMANIntAct31413325 details
TRAF3_HUMANSHAN3_HUMANMINT21653829 details
TRAF3_HUMANSRC_HUMANBioGRID, HPRD10635328 19419966 details
TRAF3_HUMANM3K5_HUMANBioGRID32445435 9774977 details
TRAF3_HUMANTNF14_HUMANBioGRID12571250 details
TRAF3_HUMANTYDP2_HUMANBioGRID, HPRD10764746 details
TRAF3_HUMANTNR16_HUMANBioGRID10514511 details
TRAF3_HUMANCD27_HUMANBioGRID, HPRD9582383 9794406 details
TRAF3_HUMANCFLAR_HUMANBioGRID10837247 details
TRAF3_HUMANTNR17_HUMANBioGRID, HPRD10903733 details
TRAF3_HUMANCIKS_HUMANBioGRID, HPRD12089335 15485634 24120361 details
TRAF3_HUMANOTUD5_HUMANBioGRID, HPRD17991829 24763515 details
TRAF3_HUMANTRAIP_HUMANBioGRID17544371 22945920 details
TRAF3_HUMANOTUB1_HUMANBioGRID19996094 24763515 31386800 details
TRAF3_HUMANOTUB2_HUMANBioGRID19996094 details
TRAF3_HUMANNLRX1_HUMANBioGRID21703539 details
TRAF3_HUMANTNIP1_HUMANBioGRID21885437 details
TRAF3_HUMANTAXB1_HUMANBioGRID21885437 details
TRAF3_HUMANTCAM1_HUMANBioGRID, HPRD14982987 16306936 16306937 17991829 24577058 28747347 31511519 details
TRAF3_HUMANOPTN_HUMANBioGRID20174559 details
TRAF3_HUMANCBLB_HUMANBioGRID17878343 details
TRAF3_HUMANMYD88_HUMANBioGRID22011580 details
TRAF3_HUMANTR13B_HUMANBioGRID12471121 details
TRAF3_HUMANTRAF1_HUMANBioGRID25996949 9718306 details
TRAF3_HUMANIKKE_HUMANBioGRID22079989 23308279 24763515 26519536 27980081 29125880 29920243 32656094 details
TRAF3_HUMANIRF3_HUMANBioGRID22079989 27980081 details
TRAF3_HUMANNF2IP_HUMANBioGRID11435475 details
TRAF3_HUMANPP2BA_HUMANBioGRID22715070 details
TRAF3_HUMANCANB1_HUMANBioGRID22715070 details
TRAF3_HUMANUBE2O_HUMANBioGRID23381138 details
TRAF3_HUMANTFG_HUMANBioGRID22792062 33411856 details
TRAF3_HUMANSC16A_HUMANBioGRID22792062 details
TRAF3_HUMANUCHL1_HUMANBioGRID23717208 details
TRAF3_HUMANKSYK_HUMANBioGRID23962979 details
TRAF3_HUMANNEMO_HUMANBioGRID22901541 details
TRAF3_HUMANPP1G_HUMANBioGRID24586659 details
TRAF3_HUMANSTING_HUMANBioGRID24622840 27716849 details
TRAF3_HUMANNMRL1_HUMANBioGRID24763515 details
TRAF3_HUMANIFIT3_HUMANBioGRID21813773 details
TRAF3_HUMANRN166_HUMANBioGRID26456228 details
TRAF3_HUMANESR1_HUMANBioGRID26186972 details
TRAF3_HUMANCREB1_HUMANBioGRID26755589 details
TRAF3_HUMANTRI14_HUMANBioGRID24379373 details
TRAF3_HUMANFOSL1_HUMANBioGRID28049150 details
TRAF3_HUMANVAV3_HUMANBioGRID27507811 details
TRAF3_HUMANOSTP_HUMANBioGRID27026194 details
TRAF3_HUMANI17RA_HUMANBioGRID28219902 details
TRAF3_HUMANKAPCB_HUMANBioGRID28934360 details
TRAF3_HUMANUBP1_HUMANBioGRID29138248 details
TRAF3_HUMANWDR82_HUMANBioGRID26519536 details
TRAF3_HUMANZC12A_HUMANBioGRID29920243 details
TRAF3_HUMANU17L2_HUMANBioGRID30038267 details
TRAF3_HUMANCACO2_HUMANBioGRID29146913 details
TRAF3_HUMANCASP2_HUMANBioGRID29875129 details
TRAF3_HUMANDHX58_HUMANBioGRID29661858 details
TRAF3_HUMANPRKN_HUMANBioGRID29903906 details
TRAF3_HUMANUBP25_HUMANBioGRID30579117 details
TRAF3_HUMANABCF1_HUMANBioGRID30770245 details
TRAF3_HUMANPINK1_HUMANBioGRID31139191 details
TRAF3_HUMANLG3BP_HUMANBioGRID31404116 details
TRAF3_HUMANMSRE_HUMANBioGRID31386800 details
TRAF3_HUMANR144B_HUMANBioGRID31509299 details
TRAF3_HUMANCRTC1_HUMANBioGRID33411856 details
TRAF3_HUMANBLK_HUMANBioGRID32779804 details
TRAF3_HUMANOTU7B_HUMANBioGRID33198776 details
TRAF3_HUMANMP2K1_HUMANHPRD8626767 details
TRAF3_HUMANRRAS2_HUMANHPRD10557073 details
TRAF3_HUMANNMDE4_HUMANHPRD10862698 details
TRAF3_HUMANTNR19_HUMANHPRD10809768 details
TRAF3_HUMANNMDZ1_HUMANHPRD10862698 details
TRAF3_HUMANBEX3_HUMANHPRD10514511 details