Entity Details

Primary name DRD5
Entity type gene
Source Source Link

Details

PrimaryID1816
RefseqGeneNG_012024
SymbolDRD5
Namedopamine receptor D5
Chromosome4
Location4p16.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-12-16
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsDRD5_HUMAN

GO terms

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GOName
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
GO:0001963 synaptic transmission, dopaminergic
GO:0001975 response to amphetamine
GO:0001992 regulation of systemic arterial blood pressure by vasopressin
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004952 dopamine neurotransmitter receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0008306 associative learning
GO:0019226 transmission of nerve impulse
GO:0031526 brush border membrane
GO:0033861 negative regulation of NAD(P)H oxidase activity
GO:0035240 dopamine binding
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0045202 synapse
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045776 negative regulation of blood pressure
GO:0045924 regulation of female receptivity
GO:0046960 sensitization
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060170 ciliary membrane
GO:0060292 long-term synaptic depression
GO:0071870 cellular response to catecholamine stimulus
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0072593 reactive oxygen species metabolic process
GO:0097730 non-motile cilium

Diseases

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Disease IDSourceNameDescription
606798 OMIMBenign essential blepharospasm (BEB)A primary focal dystonia affecting the orbicularis oculi muscles. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. BEB usually begins in middle age. Initial symptoms include eye irritation and frequent blinking, progressing to involuntary spasms of eyelid closure. Patients have normal eyes. The visual disturbance is due solely to the forced closure of the eyelids. In severe cases, this can lead to functional blindness. Disease susceptibility may be associated with variants affecting the gene represented in this entry.

Interactions

7 interactions

InteractorPartnerSourcesPublicationsLink
DRD5NOTCH2NLABioGRID, IntAct32296183 details
DRD5GABRG2BioGRID, HPRD10659839 details
DRD5GNASBioGRID9603210 details
DRD5GNAZBioGRID, HPRD9603210 details
DRD5NCS1HPRD12351722 details
DRD5GNA13BioGRID, HPRD12623966 details
DRD5GNA12BioGRID, HPRD12623966 details