Entity Details

Primary name WRN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14191
EntryNameWRN_HUMAN
FullNameWerner syndrome ATP-dependent helicase
TaxID9606
Evidenceevidence at protein level
Length1432
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesWRN

GO terms

Show/Hide Table
GOName
GO:0000287 magnesium ion binding
GO:0000400 four-way junction DNA binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000731 DNA synthesis involved in DNA repair
GO:0000781 chromosome, telomeric region
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0007420 brain development
GO:0007568 aging
GO:0007569 cell aging
GO:0008408 3'-5' exonuclease activity
GO:0009267 cellular response to starvation
GO:0009378 four-way junction helicase activity
GO:0010225 response to UV-C
GO:0010259 multicellular organism aging
GO:0016607 nuclear speck
GO:0016887 ATP hydrolysis activity
GO:0030145 manganese ion binding
GO:0031297 replication fork processing
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032405 MutLalpha complex binding
GO:0032508 DNA duplex unwinding
GO:0040009 regulation of growth rate
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043005 neuron projection
GO:0043138 3'-5' DNA helicase activity
GO:0044806 G-quadruplex DNA unwinding
GO:0044877 protein-containing complex binding
GO:0051345 positive regulation of hydrolase activity
GO:0051880 G-quadruplex DNA binding
GO:0061749 forked DNA-dependent helicase activity
GO:0061820 telomeric D-loop disassembly
GO:0061821 telomeric D-loop binding
GO:0061849 telomeric G-quadruplex DNA binding
GO:0070337 3'-flap-structured DNA binding
GO:0071480 cellular response to gamma radiation
GO:0090399 replicative senescence
GO:0090656 t-circle formation
GO:0098530 positive regulation of strand invasion
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902570 protein localization to nucleolus
GO:1905773 8-hydroxy-2'-deoxyguanosine DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR002121 HRDC domainDomainDomain
IPR002562 3'-5' exonuclease domainDomainDomain
IPR004589 DNA helicase, ATP-dependent, RecQ typeFamilyFamily
IPR010997 HRDC-like superfamilyFamilyHomologous superfamily
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR018982 RQC domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029491 Helicase Helix-turn-helix domainDomainDomain
IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
277700 OMIMWerner syndrome (WRN)A rare autosomal recessive progeroid syndrome characterized by the premature onset of multiple age-related disorders, including atherosclerosis, cancer, non-insulin-dependent diabetes mellitus, ocular cataracts and osteoporosis. The major cause of death, at a median age of 47, is myocardial infarction. The disease is caused by variants affecting the gene represented in this entry.
114500 OMIMColorectal cancer (CRC)A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
WRN_HUMANWRN_HUMANBioGRID, MINT10783163 details
WRN_HUMANXRCC5_HUMANBioGRID, HPRD, IntAct, MINT, Molecular Connections10783163 10880505 11328876 12177300 12937274 14734561 21679440 26496610 details
WRN_HUMANXRCC6_HUMANBioGRID, HPRD, IntAct, MINT10783163 10880505 11328876 12177300 14734561 26496610 28514442 30585729 details
WRN_HUMANRFA1_HUMANBioGRID, HPRD, IntAct, MINT10373438 15735006 15965237 24126761 24332808 26474068 27723720 30279242 details
WRN_HUMANPARP1_HUMANBioGRID, HPRD, IntAct, MINT14596914 14734561 details
WRN_HUMANH2AX_HUMANBioGRID, HPRD, MINT15733840 20802463 details
WRN_HUMANRAD52_HUMANBioGRID, HPRD, IntAct12750383 17118963 details
WRN_HUMANTERF2_HUMANBioGRID, HPRD, IntAct12181313 18212065 details
WRN_HUMANBLM_HUMANBioGRID, HPRD, IntAct11919194 details
WRN_HUMANFEN1_HUMANBioGRID, HPRD, IntAct11598021 12356323 14657243 14688284 16326861 details
WRN_HUMANP53_HUMANBioGRID, HPRD, IntAct11399766 11427532 12080066 15735006 details
WRN_HUMANSIR1_HUMANBioGRID, IntAct, UniProt18203716 19343720 details
WRN_HUMANRAD51_HUMANBioGRID, DIP17118963 18562274 details
WRN_HUMANBRCA1_HUMANBioGRID, UniProt16714450 24709898 29656893 details
WRN_HUMANMDC1_HUMANBioGRID14578343 details
WRN_HUMANATM_HUMANBioGRID, HPRD10608806 10839545 11252893 details
WRN_HUMANATR_HUMANBioGRID10608806 17118963 22159421 details
WRN_HUMANPRKDC_HUMANBioGRID, HPRD10608806 11889123 details
WRN_HUMANPCNA_HUMANBioGRID, HPRD10871373 12633936 12750383 20600238 details
WRN_HUMANWRIP1_HUMANBioGRID, HPRD11301316 details
WRN_HUMANCAF1A_HUMANBioGRID17173071 details
WRN_HUMANDPOLB_HUMANBioGRID17173071 details
WRN_HUMANDHX9_HUMANBioGRID15995249 17498979 details
WRN_HUMANATRX_HUMANBioGRID17118963 details
WRN_HUMANFSBP_HUMANBioGRID17118963 details
WRN_HUMANRA54B_HUMANBioGRID17118963 details
WRN_HUMANCDN2A_HUMANBioGRID15355988 details
WRN_HUMANARF_HUMANBioGRID, HPRD15355988 details
WRN_HUMANSUMO1_HUMANBioGRID16524884 details
WRN_HUMANSUMO2_HUMANBioGRID16524884 details
WRN_HUMANPOLK_HUMANBioGRID25294835 details
WRN_HUMANRAD9A_HUMANBioGRID22002307 details
WRN_HUMANRAD1_HUMANBioGRID22002307 details
WRN_HUMANBARD1_HUMANBioGRID16714450 details
WRN_HUMANMDM2_HUMANBioGRID30532073 details
WRN_HUMANMIB1_HUMANBioGRID32652764 details
WRN_HUMANKAP1_HUMANHPRD12067711 details
WRN_HUMANNALP2_HUMANMINT15733840 details
WRN_HUMANTERA_HUMANBioGRID, HPRD, IntAct12937274 15037256 details
WRN_HUMANUBC_HUMANMINT18588880 details
WRN_HUMANRFA2_HUMANBioGRID, MINT20802463 24126761 24332808 30279242 details
WRN_HUMANRFA3_HUMANBioGRID, IntAct, MINT24126761 24332808 27173435 30279242 unassigned1312 details
WRN_HUMANARL3_HUMANBioGRID, IntAct27173435 unassigned1312 details
WRN_HUMANDPOLL_HUMANBioGRID, IntAct27173435 unassigned1312 details
WRN_HUMANSP16H_HUMANBioGRID, IntAct27173435 unassigned1312 details
WRN_HUMANCBX5_HUMANDIP25931448 details
WRN_HUMANRPAC1_HUMANBioGRID, HPRD11971179 details
WRN_HUMANNBN_HUMANBioGRID15733840 20600238 details
WRN_HUMANCDC5L_HUMANBioGRID16223718 details
WRN_HUMANPML_HUMANBioGRID21639834 details
WRN_HUMANNKX21_HUMANBioGRID28192407 details
WRN_HUMANHERC2_HUMANBioGRID30279242 details
WRN_HUMANHDAC1_HUMANBioGRID27672210 details
WRN_HUMANHDAC2_HUMANBioGRID27672210 details
WRN_HUMANMOV10_HUMANBioGRID29395067 details
WRN_HUMANNXF1_HUMANBioGRID29395067 details
WRN_HUMANCPSF1_HUMANBioGRID29395067 details
WRN_HUMANSMG7_HUMANBioGRID29395067 details
WRN_HUMANILF3_HUMANBioGRID29395067 details
WRN_HUMANSHLD2_HUMANBioGRID30154076 details
WRN_HUMANDPOD2_HUMANHPRD11027336 details