Entity Details

Primary name SMC1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14683
EntryNameSMC1A_HUMAN
FullNameStructural maintenance of chromosomes protein 1A
TaxID9606
Evidenceevidence at protein level
Length1233
SequenceStatuscomplete
DateCreated2003-03-25
DateModified2021-06-02

Ontological Relatives

GenesSMC1A

GO terms

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GOName
GO:0000070 mitotic sister chromatid segregation
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000794 condensed nuclear chromosome
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0008278 cohesin complex
GO:0009314 response to radiation
GO:0016363 nuclear matrix
GO:0016887 ATP hydrolysis activity
GO:0019827 stem cell population maintenance
GO:0030893 meiotic cohesin complex
GO:0036033 mediator complex binding
GO:0046982 protein heterodimerization activity
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0072423 response to DNA damage checkpoint signaling
GO:0090307 mitotic spindle assembly
GO:0097431 mitotic spindle pole

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR003395 RecF/RecN/SMC, N-terminalDomainDomain
IPR010935 SMCs flexible hingeDomainDomain
IPR024704 Structural maintenance of chromosomes proteinFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR028468 Smc1, ATP-binding cassette domainDomainDomain
IPR029683 Structural maintenance of chromosomes protein 1A, metazoanFamilyFamily
IPR036277 SMCs flexible hinge superfamilyFamilyHomologous superfamily

Diseases

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Interactions

88 interactions

InteractorPartnerSourcesPublicationsLink
SMC1A_HUMANMCM7_HUMANBioGRID, HPRD, IntAct16438930 22939629 details
SMC1A_HUMANSTAG1_HUMANBioGRID, DIP, IntAct, UniProt10931856 11076961 17112726 17113138 26344197 26496610 29867216 31010829 details
SMC1A_HUMANRAD21_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10931856 11590136 15737063 17112726 17113138 19308699 20818333 21043528 22145905 22885700 22939629 23242214 24981860 26344197 26496610 28514442 31010829 details
SMC1A_HUMANATM_HUMANBioGRID, HPRD, UniProt11877376 11877377 details
SMC1A_HUMANNDC80_HUMANBioGRID, HPRD, MINT23361318 26344197 9295362 details
SMC1A_HUMANAMOT_HUMANBioGRID, IntAct23414517 details
SMC1A_HUMANSUMO2_HUMANBioGRID32786267 details
SMC1A_HUMANFGF14_HUMANBioGRID, IntAct32296183 details
SMC1A_HUMANRPGR_HUMANBioGRID, HPRD16043481 details
SMC1A_HUMANMSH6_HUMANBioGRID14657349 details
SMC1A_HUMANMET_HUMANHPRD15546961 details
SMC1A_HUMANPCNA_HUMANUniProt26030842 details
SMC1A_HUMANESR1_HUMANBioGRID20348541 details
SMC1A_HUMANRFC1_HUMANBioGRID, HPRD, IntAct16438930 26344197 details
SMC1A_HUMANMCM6_HUMANBioGRID, HPRD, IntAct16438930 27173435 unassigned1312 details
SMC1A_HUMANDPOLA_HUMANBioGRID, HPRD, IntAct16438930 details
SMC1A_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
SMC1A_HUMANWAPL_HUMANBioGRID, DIP, IntAct, UniProt17112726 17113138 20360068 23242214 26496610 31010829 details
SMC1A_HUMANNEK6_HUMANIntAct17353931 details
SMC1A_HUMANSMC3_HUMANBioGRID, DIP, HPRD, IntAct, UniProt10931856 11076961 11590136 11877376 12759374 17112726 17113138 17349791 18832153 21111234 21880767 22885700 22939629 23242214 24981860 26344197 26496610 27173435 30021884 31010829 9789013 unassigned1312 details
SMC1A_HUMANSTAG2_HUMANBioGRID, DIP, IntAct, MINT, UniProt10931856 17112726 17113138 19629043 23242214 24981860 26344197 26496610 29263825 29867216 31010829 details
SMC1A_HUMANPDS5B_HUMANBioGRID, DIP, IntAct, UniProt15855230 17112726 17113138 23242214 26344197 26496610 31010829 details
SMC1A_HUMANPDS5A_HUMANBioGRID, DIP, IntAct, UniProt15855230 17112726 17113138 23242214 26344197 26496610 31010829 details
SMC1A_HUMANBRCA1_HUMANBioGRID, HPRD, UniProt11877377 25184681 26831064 details
SMC1A_HUMANHSF1_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC1A_HUMANNS1BP_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC1A_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC1A_HUMANCDCA5_HUMANBioGRID, DIP, IntAct22885700 23242214 26186194 26496610 31010829 details
SMC1A_HUMANCTCF_HUMANBioGRID, MINT18219272 details
SMC1A_HUMANTF3C4_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC1A_HUMANMCM2_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC1A_HUMANCTF18_HUMANBioGRID12930902 details
SMC1A_HUMANATRX_HUMANBioGRID, UniProt20159591 details
SMC1A_HUMANPLK1_HUMANBioGRID, IntAct26344197 27173435 unassigned1312 details
SMC1A_HUMANNUMA1_HUMANBioGRID, HPRD11590136 details
SMC1A_HUMANSMC1A_HUMANBioGRID16438930 18832153 details
SMC1A_HUMANMLH1_HUMANBioGRID17148452 details
SMC1A_HUMANAIRE_HUMANBioGRID20085707 details
SMC1A_HUMANEP15R_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC1A_HUMANPHF1_HUMANBioGRID18385154 details
SMC1A_HUMANMCM4_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC1A_HUMANSMRCD_HUMANBioGRID21549307 details
SMC1A_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
SMC1A_HUMANSTAG3_HUMANBioGRID11483963 details
SMC1A_HUMANRPB1_HUMANBioGRID21880767 details
SMC1A_HUMANRAE1L_HUMANBioGRID, DIP18832153 details
SMC1A_HUMANSRRM1_HUMANBioGRID16159877 details
SMC1A_HUMANSF3B3_HUMANBioGRID22939629 26344197 31010829 details
SMC1A_HUMANSGO1_HUMANDIP23242214 details
SMC1A_HUMANPAXI1_HUMANBioGRID17925232 details
SMC1A_HUMANSYCP3_HUMANBioGRID12759374 details
SMC1A_HUMANTHA_HUMANBioGRID17242407 details
SMC1A_HUMANMGMT_HUMANBioGRID16226712 details
SMC1A_HUMANSIR6_HUMANBioGRID24169447 details
SMC1A_HUMANSMCA5_HUMANBioGRID12198550 details
SMC1A_HUMANBARD1_HUMANBioGRID16391231 details
SMC1A_HUMANTHB_HUMANBioGRID17242407 details
SMC1A_HUMANABCE1_HUMANBioGRID25659154 details
SMC1A_HUMANNSE2_HUMANBioGRID22751501 details
SMC1A_HUMANEHMT2_HUMANBioGRID20670891 details
SMC1A_HUMANBRD4_HUMANBioGRID24945803 31239290 32416067 details
SMC1A_HUMANATR_HUMANBioGRID15640246 details
SMC1A_HUMANEFMT3_HUMANBioGRID23349634 details
SMC1A_HUMANWFDC5_HUMANBioGRID17112726 details
SMC1A_HUMANU5S1_HUMANBioGRID28515276 31010829 details
SMC1A_HUMANKDM1B_HUMANBioGRID20670891 details
SMC1A_HUMANDERL1_HUMANBioGRID28137758 details
SMC1A_HUMANNIPBL_HUMANBioGRID20720539 31010829 details
SMC1A_HUMANDCA15_HUMANBioGRID31452512 details
SMC1A_HUMANHDAC5_HUMANBioGRID21081666 details
SMC1A_HUMANANR55_HUMANBioGRID31620119 details
SMC1A_HUMANCDK8_HUMANBioGRID20720539 details
SMC1A_HUMANSF3B1_HUMANBioGRID31010829 details
SMC1A_HUMANDDX47_HUMANBioGRID31010829 details
SMC1A_HUMANBLM_HUMANHPRD11877377 details
SMC1A_HUMANFBX6_HUMANBioGRID22268729 details
SMC1A_HUMANEP300_HUMANBioGRID24945803 details
SMC1A_HUMANRN126_HUMANBioGRID26508657 details
SMC1A_HUMANH2AX_HUMANBioGRID26095369 details
SMC1A_HUMANRRP5_HUMANBioGRID31010829 details
SMC1A_HUMANTRI29_HUMANBioGRID26095369 details
SMC1A_HUMANHSP7C_HUMANBioGRID31010829 details
SMC1A_HUMANPRP31_HUMANBioGRID31010829 details
SMC1A_HUMANRBM15_HUMANBioGRID31010829 details
SMC1A_HUMANDSRAD_HUMANBioGRID31010829 details
SMC1A_HUMANU520_HUMANBioGRID31010829 details
SMC1A_HUMANMSH2_HUMANHPRD14657349 details
SMC1A_HUMANHNRH1_HUMANBioGRID31010829 details