Entity Details

Primary name PTH
Entity type gene
Source Source Link

Details

PrimaryID5741
RefseqGeneNG_008962
SymbolPTH
Nameparathyroid hormone
Chromosome11
Location11p15.3
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1991-07-03
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPTHY_HUMAN

GO terms

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GOName
GO:0001501 skeletal system development
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007266 Rho protein signal transduction
GO:0007267 cell-cell signaling
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0010288 response to lead ion
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010960 magnesium ion homeostasis
GO:0030501 positive regulation of bone mineralization
GO:0031856 parathyroid hormone receptor binding
GO:0031857 type 1 parathyroid hormone receptor binding
GO:0032331 negative regulation of chondrocyte differentiation
GO:0033280 response to vitamin D
GO:0034645 cellular macromolecule biosynthetic process
GO:0042493 response to drug
GO:0045453 bone resorption
GO:0045471 response to ethanol
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046058 cAMP metabolic process
GO:0046326 positive regulation of glucose import
GO:0046686 response to cadmium ion
GO:0047485 protein N-terminus binding
GO:0048018 receptor ligand activity
GO:0048873 homeostasis of number of cells within a tissue
GO:0051428 peptide hormone receptor binding
GO:0055062 phosphate ion homeostasis
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0071107 response to parathyroid hormone
GO:0071774 response to fibroblast growth factor
GO:0071864 positive regulation of cell proliferation in bone marrow
GO:0071866 negative regulation of apoptotic process in bone marrow cell
GO:0090290 positive regulation of osteoclast proliferation
GO:1900158 negative regulation of bone mineralization involved in bone maturation

Diseases

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Disease IDSourceNameDescription
146200 OMIMHypoparathyroidism, familial isolated, 1 (FIH1)A form of hypoparathyroidism, a disorder characterized by hypocalcemia and hyperphosphatemia due to a deficiency of parathyroid hormone. Clinical features include seizures, tetany and cramps. FIH1 inheritance can be autosomal dominant or recessive. The disease is caused by variants affecting the gene represented in this entry.

Interactions

9 interactions

InteractorPartnerSourcesPublicationsLink
PTHBAG6BioGRID, HPRD, IntAct16169070 details
PTHFEZ1BioGRID, HPRD, IntAct16169070 details
PTHASPHBioGRID, IntAct32296183 details
PTHPTH1RBioGRID, HPRD, IntAct19674967 9108031 details
PTHMEP1ABioGRID, HPRD11278902 details
PTHPTH2RBioGRID, HPRD9482662 details
PTHARFGEF3BioGRID11551928 details
PTHPTHHPRD10837469 details
PTHTP53BioGRID32807901 details