Entity Details

Primary name INAVA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ3KP66
EntryNameINAVA_HUMAN
FullNameInnate immunity activator protein
TaxID9606
Evidenceevidence at protein level
Length663
SequenceStatuscomplete
DateCreated2006-10-03
DateModified2021-06-02

Ontological Relatives

GenesINAVA

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0002221 pattern recognition receptor signaling pathway
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031398 positive regulation of protein ubiquitination
GO:0032494 response to peptidoglycan
GO:0032495 response to muramyl dipeptide
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032733 positive regulation of interleukin-10 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0034334 adherens junction maintenance
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0060729 intestinal epithelial structure maintenance
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:1903409 reactive oxygen species biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR021774 Domain of unknown function DUF3338DomainDomain
IPR039106 Innate immunity activator proteinFamilyFamily
IPR043447 CCDC120/INAVAFamilyFamily

Diseases

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Disease IDSourceNameDescription
618077 OMIMInflammatory bowel disease 29 (IBD29)A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Disease susceptibility is associated with variants affecting the gene represented in this entry.