Entity Details

Primary name GRDN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ3V6T2
EntryNameGRDN_HUMAN
FullNameGirdin
TaxID9606
Evidenceevidence at protein level
Length1871
SequenceStatuscomplete
DateCreated2007-05-15
DateModified2021-06-02

Ontological Relatives

GenesCCDC88A

GO terms

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GOName
GO:0001932 regulation of protein phosphorylation
GO:0001965 G-protein alpha-subunit binding
GO:0003779 actin binding
GO:0005080 protein kinase C binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005092 GDP-dissociation inhibitor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005158 insulin receptor binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0008017 microtubule binding
GO:0010975 regulation of neuron projection development
GO:0016020 membrane
GO:0016477 cell migration
GO:0030027 lamellipodium
GO:0030032 lamellipodium assembly
GO:0030142 COPI-coated Golgi to ER transport vesicle
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0031122 cytoplasmic microtubule organization
GO:0031410 cytoplasmic vesicle
GO:0031682 G-protein gamma-subunit binding
GO:0031929 TOR signaling
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0035091 phosphatidylinositol binding
GO:0036064 ciliary basal body
GO:0042127 regulation of cell population proliferation
GO:0042169 SH2 domain binding
GO:0042803 protein homodimerization activity
GO:0043184 vascular endothelial growth factor receptor 2 binding
GO:0043422 protein kinase B binding
GO:0045724 positive regulation of cilium assembly
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0051496 positive regulation of stress fiber assembly
GO:0051959 dynein light intermediate chain binding
GO:0061024 membrane organization
GO:0072660 maintenance of protein location in plasma membrane
GO:1903566 positive regulation of protein localization to cilium

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle

Domains

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DomainNameCategoryType
IPR001715 Calponin homology domainDomainDomain
IPR027717 GirdinFamilyFamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR043936 HOOK, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
617507 OMIMPEHO-like syndrome (PEHOL)An autosomal recessive syndrome characterized by microcephaly and moderately severe hypotonia manifesting at birth, seizures that progress into infantile spasms with hypsarrhythmia, brain atrophy with bilateral polymicrogyria and pachygyria, thin corpus callosum, and mild reduction in cerebellar vermis volume. Patients also display optic atrophy, severe cognitive delay, puffiness of the maxillary region of the face, and edema of the dorsum of the hands and feet. The disease is caused by variants affecting the gene represented in this entry.

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
GRDN_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
GRDN_HUMANNDEL1_HUMANBioGRID, IntAct17043677 31413325 details
GRDN_HUMANBRAF_HUMANBioGRID, IntAct20936779 details
GRDN_HUMANKAPCA_HUMANBioGRID, IntAct20936779 details
GRDN_HUMANHD_HUMANIntAct17500595 details
GRDN_HUMANEXOC1_HUMANBioGRID, IntAct17043677 31413325 details
GRDN_HUMANAKT1_HUMANBioGRID, HPRD15753085 16139227 details
GRDN_HUMANGNAI3_HUMANBioGRID21209316 25187647 26186194 details
GRDN_HUMANEGFR_HUMANBioGRID15882442 25187647 details
GRDN_HUMANPTN6_HUMANBioGRID21799016 details
GRDN_HUMANVGFR2_HUMANBioGRID25187647 details
GRDN_HUMANINSR_HUMANBioGRID25187647 details
GRDN_HUMANAAKB1_HUMANIntAct17353931 details
GRDN_HUMANPPARG_HUMANIntAct20195357 details
GRDN_HUMANVIP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANSC24B_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANUB2D2_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANPLEC_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANAAK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANQSER1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANEYA4_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANLUZP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANURGCP_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANDVL3_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANNUP88_HUMANBioGRID, IntAct27173435 unassigned1312 details
GRDN_HUMANFMR1_HUMANIntAct31413325 details
GRDN_HUMANMT21A_HUMANBioGRID23349634 details
GRDN_HUMANMT21C_HUMANBioGRID23349634 details
GRDN_HUMANGRDN_HUMANBioGRID16139227 details
GRDN_HUMANSNX1_HUMANBioGRID15882442 details
GRDN_HUMANHEY1_HUMANBioGRID27129302 details
GRDN_HUMANDYHC1_HUMANBioGRID28718761 details
GRDN_HUMANDCTN1_HUMANBioGRID28718761 details