Entity Details

Primary name XPNPEP2
Entity type gene
Source Source Link

Details

PrimaryID7512
RefseqGeneNG_011479
SymbolXPNPEP2
NameX-prolyl aminopeptidase 2
ChromosomeX
LocationXq26.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsXPP2_HUMAN

GO terms

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GOName
GO:0004177 aminopeptidase activity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
GO:0070062 extracellular exosome

Diseases

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Disease IDSourceNameDescription
300909 OMIMAngioedema induced by ACE inhibitors (AEACEI)A potentially life-threatening side effect of ACE inhibitors that appears in a subset of patients taking these drugs for hypertension and cardiovascular disease treatment. AEACEI is characterized by swelling of the face, lips, tongue, and airway that can lead to suffocation and death if severe. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
XPNPEP2PXNBioGRID12611588 details
XPNPEP2H1-5BioGRID, IntAct30021884 details