Entity Details

Primary name NAKD2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ4G0N4
EntryNameNAKD2_HUMAN
FullNameNAD kinase 2, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length442
SequenceStatuscomplete
DateCreated2007-07-24
DateModified2021-06-02

Ontological Relatives

GenesNADK2

GO terms

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GOName
GO:0003951 NAD+ kinase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006741 NADP biosynthetic process
GO:0019674 NAD metabolic process
GO:0042803 protein homodimerization activity

Subcellular Location

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Subcellular Location
Mitochondrion

Domains

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DomainNameCategoryType
IPR002504 NAD kinaseFamilyFamily
IPR012355 NAD kinase 2, mitochondrialFamilyFamily
IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamilyFamilyHomologous superfamily
IPR017437 ATP-NAD kinase, PpnK-type, C-terminalFamilyHomologous superfamily
IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminalFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
616034 OMIM2,4-dienoyl-CoA reductase deficiency (DECRD)A rare, autosomal recessive, inborn error of polyunsaturated fatty acids and lysine metabolism, resulting in mitochondrial dysfunction. Affected individuals have a severe encephalopathy with neurologic and metabolic abnormalities beginning in early infancy. Laboratory studies show increased C10:2 carnitine levels and hyperlysinemia. The disease is caused by variants affecting the gene represented in this entry.

Interactions

0 interactions

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