Entity Details

Primary name DCAF8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5TAQ9
EntryNameDCAF8_HUMAN
FullNameDDB1- and CUL4-associated factor 8
TaxID9606
Evidenceevidence at protein level
Length597
SequenceStatuscomplete
DateCreated2007-07-24
DateModified2021-06-02

Ontological Relatives

GenesDCAF8

GO terms

Show/Hide Table
GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016567 protein ubiquitination
GO:0043687 post-translational protein modification
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
610100 OMIMGiant axonal neuropathy 2, autosomal dominant (GAN2)An autosomal dominant peripheral axonal neuropathy characterized by onset of distal sensory impairment with lower extremity muscle weakness and atrophy after the second decade. Clinical features include foot deformities apparent in childhood, and cardiomyopathy in severely affected individuals. Sural nerve biopsy shows giant axonal swelling with neurofilament accumulation. The disease is caused by variants affecting the gene represented in this entry.

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
DCAF8_HUMANGTPB3_HUMANBioGRID, HPRD, IntAct16189514 details
DCAF8_HUMANMDFI_HUMANBioGRID, HPRD, IntAct16189514 19060904 21516116 25416956 details
DCAF8_HUMANCUL4B_HUMANBioGRID, IntAct16949367 21145461 28514442 31155351 31973889 details
DCAF8_HUMANSUV91_HUMANBioGRID, MINT23455924 details
DCAF8_HUMANANM8_HUMANBioGRID, MINT23455924 details
DCAF8_HUMANANM1_HUMANBioGRID, MINT23455924 details
DCAF8_HUMANTNS2_HUMANBioGRID, IntAct25814554 details
DCAF8_HUMANP55G_HUMANBioGRID, IntAct25814554 details
DCAF8_HUMANRBPMS_HUMANBioGRID, IntAct25416956 details
DCAF8_HUMANTHAP1_HUMANBioGRID, IntAct25416956 details
DCAF8_HUMANDDB1_HUMANBioGRID, DIP, HPRD, IntAct16949367 16964240 19295130 19966799 24500646 28514442 31155351 31257023 31391242 32235678 details
DCAF8_HUMANTRI54_HUMANBioGRID, IntAct31391242 details
DCAF8_HUMANGSK3A_HUMANBioGRID, UniProt30824926 details
DCAF8_HUMANNC2B_HUMANIntAct32814053 details
DCAF8_HUMANGRN_HUMANIntAct32814053 details
DCAF8_HUMANTF2B_HUMANIntAct32814053 details
DCAF8_HUMANHSPB1_HUMANIntAct32814053 details
DCAF8_HUMANNFL_HUMANIntAct32814053 details
DCAF8_HUMANMERL_HUMANIntAct32814053 details
DCAF8_HUMANPRKN_HUMANIntAct32814053 details
DCAF8_HUMANPEX1_HUMANIntAct32814053 details
DCAF8_HUMANVHL_HUMANIntAct32814053 details
DCAF8_HUMANWFS1_HUMANIntAct32814053 details
DCAF8_HUMANTF3C3_HUMANIntAct32814053 details
DCAF8_HUMANKIF1B_HUMANIntAct32814053 details
DCAF8_HUMANRNF11_HUMANIntAct32814053 details
DCAF8_HUMANHTRA2_HUMANIntAct32814053 details
DCAF8_HUMANJPH3_HUMANIntAct32814053 details
DCAF8_HUMANSPRE1_HUMANIntAct32814053 details
DCAF8_HUMANTADBP_HUMANIntAct32814053 details
DCAF8_HUMANRAF1_HUMANBioGRID16364241 details
DCAF8_HUMANRAN_HUMANMINT22500989 details
DCAF8_HUMANIMA5_HUMANBioGRID, MINT22500989 details
DCAF8_HUMANIMB1_HUMANBioGRID, MINT22500989 details
DCAF8_HUMANXPO1_HUMANBioGRID, MINT22500989 26673895 details
DCAF8_HUMANCUL4A_HUMANBioGRID, IntAct16949367 19295130 21145461 28514442 31155351 31973889 32235678 details
DCAF8_HUMANTRI63_HUMANIntAct31391242 details
DCAF8_HUMANSQSTM_HUMANIntAct31391242 details
DCAF8_HUMANDDA1_HUMANBioGRID19295130 31155351 details
DCAF8_HUMANCSN2_HUMANBioGRID19295130 details
DCAF8_HUMANCSN3_HUMANBioGRID19295130 details
DCAF8_HUMANMPIP1_HUMANBioGRID27462461 details