Entity Details

Primary name PRP8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ6P2Q9
EntryNamePRP8_HUMAN
FullNamePre-mRNA-processing-splicing factor 8
TaxID9606
Evidenceevidence at protein level
Length2335
SequenceStatuscomplete
DateCreated2005-06-07
DateModified2021-06-02

Ontological Relatives

GenesPRPF8

GO terms

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GOName
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005682 U5 snRNP
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030623 U5 snRNA binding
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0070122 isopeptidase activity
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0071005 U2-type precatalytic spliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071356 cellular response to tumor necrosis factor
GO:0097157 pre-mRNA intronic binding

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000555 JAB1/MPN/MOV34 metalloenzyme domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR012591 PRO8NT domainDomainDomain
IPR012592 PROCN domainDomainDomain
IPR012984 PROCT domainDomainDomain
IPR019580 Pre-mRNA-processing-splicing factor 8, U6-snRNA-bindingDomainDomain
IPR019581 Pre-mRNA-processing-splicing factor 8, U5-snRNA-bindingDomainDomain
IPR019582 RNA recognition motif, spliceosomal PrP8DomainDomain
IPR021983 PRP8 domain IV coreDomainDomain
IPR027652 Pre-mRNA-processing-splicing factor 8FamilyFamily
IPR037518 MPN domainDomainDomain
IPR042516 Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamilyFamilyHomologous superfamily
IPR043172 Prp8 RNase domain IV, palm regionFamilyHomologous superfamily
IPR043173 Prp8 RNase domain IV, fingers regionFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
600059 OMIMRetinitis pigmentosa 13 (RP13)A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. The disease is caused by variants affecting the gene represented in this entry.

Interactions

64 interactions

InteractorPartnerSourcesPublicationsLink
PRP8_HUMANSNR40_HUMANBioGRID, IntAct, UniProt16723661 17353931 22939629 26186194 26344197 28514442 28515276 34079125 9774689 details
PRP8_HUMANU5S1_HUMANBioGRID, IntAct, UniProt16723661 17317632 22939629 25263594 26344197 27173435 28515276 34079125 9774689 unassigned1312 details
PRP8_HUMANU520_HUMANBioGRID, DIP, IntAct, UniProt16723661 17317632 22939629 23704370 26344197 27173435 28515276 31914407 34079125 9774689 unassigned1312 details
PRP8_HUMANSF3B4_HUMANBioGRID, MINT22365833 28515276 details
PRP8_HUMANSLU7_HUMANBioGRID, MINT22365833 details
PRP8_HUMANPCBP1_HUMANBioGRID, MINT22365833 28515276 details
PRP8_HUMANHNRH2_HUMANBioGRID, MINT22365833 details
PRP8_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
PRP8_HUMANPRP6_HUMANBioGRID, IntAct, UniProt16723661 22939629 26344197 27173435 28515276 34079125 unassigned1312 details
PRP8_HUMANSF3B2_HUMANBioGRID, MINT22365833 28515276 details
PRP8_HUMANTADBP_HUMANIntAct32814053 details
PRP8_HUMANPRP19_HUMANBioGRID, MINT22365833 22939629 26344197 28515276 34079125 details
PRP8_HUMANUBC_HUMANBioGRID20595234 details
PRP8_HUMANSPF27_HUMANBioGRID, MINT22365833 28515276 34079125 details
PRP8_HUMANPAI2_HUMANBioGRID, HPRD15346200 details
PRP8_HUMANPRP8_HUMANBioGRID16723661 17317632 28515276 details
PRP8_HUMANWDR83_HUMANBioGRID, MINT22365833 details
PRP8_HUMANZN830_HUMANBioGRID, MINT22365833 details
PRP8_HUMANSUMO2_HUMANBioGRID32786267 details
PRP8_HUMANECD_HUMANBioGRID, IntAct, UniProt22939629 26711270 28514442 28515276 28561026 34079125 details
PRP8_HUMANGPKOW_HUMANBioGRID, MINT22365833 details
PRP8_HUMANSND1_HUMANBioGRID, DIP17632523 details
PRP8_HUMANPRPF3_HUMANBioGRID20595234 22939629 26344197 28515276 details
PRP8_HUMANERG_HUMANBioGRID21575865 24591637 details
PRP8_HUMANUBC9_HUMANBioGRID19596686 details
PRP8_HUMANABCA1_HUMANBioGRID12054535 details
PRP8_HUMANATX1_HUMANIntAct32814053 details
PRP8_HUMANPIN1_HUMANBioGRID16055720 details
PRP8_HUMANH2B1C_HUMANBioGRID31152661 details
PRP8_HUMANPTEN_HUMANBioGRID31685992 details
PRP8_HUMANS22A2_HUMANBioGRID31318583 details
PRP8_HUMANNEDD4_HUMANBioGRID16055720 details
PRP8_HUMANH2B1D_HUMANBioGRID31152661 details
PRP8_HUMANP53_HUMANBioGRID31152661 32807901 details
PRP8_HUMANBRE1A_HUMANBioGRID31152661 details
PRP8_HUMANSF3A2_HUMANBioGRID, MINT17332742 22939629 details
PRP8_HUMANCD2B2_HUMANBioGRID, IntAct17353931 22939629 26344197 27173435 28514442 28515276 28561026 34079125 unassigned1312 details
PRP8_HUMANNFKB2_HUMANIntAct14743216 details
PRP8_HUMANRIOK1_HUMANBioGRID, IntAct21081503 27173435 unassigned1312 details
PRP8_HUMANSMU1_HUMANBioGRID, IntAct22939629 27173435 28515276 unassigned1312 details
PRP8_HUMANAAR2_HUMANBioGRID, IntAct22939629 26186194 26344197 28514442 28515276 28561026 34079125 details
PRP8_HUMANSNUT1_HUMANBioGRID, IntAct11350945 22939629 26344197 28515276 30021884 details
PRP8_HUMANSRRM1_HUMANBioGRID10809668 16159877 details
PRP8_HUMANZBT7B_HUMANBioGRID20810990 details
PRP8_HUMANDHX9_HUMANBioGRID, HPRD15034300 22939629 28515276 details
PRP8_HUMANSRPK1_HUMANBioGRID15034300 details
PRP8_HUMANU2AF2_HUMANBioGRID26641092 details
PRP8_HUMANTLS1_HUMANBioGRID26472760 28515276 details
PRP8_HUMANGGYF2_HUMANBioGRID20696395 details
PRP8_HUMANSIR6_HUMANBioGRID24169447 details
PRP8_HUMANANDR_HUMANBioGRID26371515 32814769 details
PRP8_HUMANTTC27_HUMANBioGRID26472760 28515276 details
PRP8_HUMANCA131_HUMANBioGRID26472760 details
PRP8_HUMANRPAP3_HUMANBioGRID28515276 34079125 details
PRP8_HUMANITA4_HUMANBioGRID22623428 details
PRP8_HUMANASCC1_HUMANBioGRID29997253 details
PRP8_HUMANRSMB_HUMANBioGRID17353931 28515276 34079125 details
PRP8_HUMANISG15_HUMANBioGRID33024031 details
PRP8_HUMANPRP31_HUMANBioGRID26344197 28088760 28515276 details
PRP8_HUMANZNHI2_HUMANBioGRID28515276 28561026 details
PRP8_HUMANRUVB1_HUMANBioGRID28515276 28561026 34079125 details
PRP8_HUMANHDAC5_HUMANBioGRID21081666 details
PRP8_HUMANRUVB2_HUMANBioGRID28515276 28561026 34079125 details
PRP8_HUMANPHF6_HUMANBioGRID22720776 details