Entity Details

Primary name COP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8NHY2
EntryNameCOP1_HUMAN
FullNameE3 ubiquitin-protein ligase COP1
TaxID9606
Evidenceevidence at protein level
Length731
SequenceStatuscomplete
DateCreated2004-11-23
DateModified2021-06-02

Ontological Relatives

GenesCOP1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0010212 response to ionizing radiation
GO:0016607 nuclear speck
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043687 post-translational protein modification
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus speckle

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR042755 E3 ubiquitin-protein ligase COP1FamilyFamily

Diseases

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Interactions

59 interactions

InteractorPartnerSourcesPublicationsLink
COP1_HUMANJUND_HUMANBioGRID, HPRD, MINT12615916 23289756 details
COP1_HUMANP53_HUMANBioGRID, HPRD, I2D, MINT15103385 16931761 21625211 23736031 27534417 29379285 details
COP1_HUMAN1433S_HUMANBioGRID, I2D, Molecular Connections20843328 21625211 details
COP1_HUMANCSN6_HUMANBioGRID, I2D19295130 21625211 33101846 details
COP1_HUMANETS2_HUMANBioGRID, IntAct25117710 26496610 26871468 details
COP1_HUMANTRIB1_HUMANBioGRID, IntAct25117710 27041596 28089446 28514442 29296815 30692133 details
COP1_HUMANETS1_HUMANBioGRID, IntAct25117710 details
COP1_HUMANSTK40_HUMANBioGRID, IntAct26186194 28089446 28514442 details
COP1_HUMANCOP1_HUMANBioGRID, HPRD12615916 16931761 21135113 23289756 details
COP1_HUMANTCPD_HUMANBioGRID16497536 24298020 details
COP1_HUMANCUL4B_HUMANBioGRID17041588 19295130 31973889 details
COP1_HUMAN1433Z_HUMANBioGRID20843328 details
COP1_HUMAN1433B_HUMANBioGRID21135113 details
COP1_HUMANUB2D2_HUMANBioGRID15103385 16931761 21625211 details
COP1_HUMANRBCC1_HUMANBioGRID23289756 details
COP1_HUMANUB2D1_HUMANBioGRID21625211 25117710 details
COP1_HUMANPTN1_HUMANBioGRID23439647 details
COP1_HUMANCDN1B_HUMANBioGRID26254224 details
COP1_HUMANMLF1_HUMANBioGRID29296815 details
COP1_HUMANSOX2_HUMANBioGRID30405104 details
COP1_HUMANSIPA1_HUMANHPRD11461903 details
COP1_HUMANJUN_HUMANBioGRID, HPRD, IntAct, MINT12615916 14739464 15994960 25117710 25609649 27534417 28514442 31155351 details
COP1_HUMANCUL4A_HUMANBioGRID, IntAct14739464 17041588 17079684 19295130 21145461 25117710 32041890 details
COP1_HUMANDDB1_HUMANBioGRID, IntAct14739464 16949367 17041588 17079684 19295130 25117710 31155351 32041890 details
COP1_HUMANDET1_HUMANBioGRID, HPRD, IntAct14739464 17452440 21572435 25117710 28514442 30692133 31155351 32041890 details
COP1_HUMANETV4_HUMANBioGRID, IntAct20062082 21572435 25117710 28373072 details
COP1_HUMANMVP_HUMANBioGRID, IntAct15994960 25117710 details
COP1_HUMANDDA1_HUMANBioGRID, IntAct19295130 25117710 31155351 details
COP1_HUMANTRIB3_HUMANBioGRID, IntAct21572435 25117710 26186194 28514442 30692133 31125554 details
COP1_HUMANETV1_HUMANBioGRID, DIP, IntAct20062082 21572435 25117710 26186194 28514442 details
COP1_HUMANETV5_HUMANBioGRID, IntAct20062082 21572435 25117710 26186194 28514442 details
COP1_HUMANTRIB2_HUMANBioGRID, IntAct, MINT25311538 28514442 details
COP1_HUMANTCPH_HUMANBioGRID, IntAct16497536 28514442 details
COP1_HUMANTCPB_HUMANBioGRID, IntAct16497536 28514442 details
COP1_HUMANTCPG_HUMANBioGRID, IntAct16497536 28514442 details
COP1_HUMANTCPZ_HUMANBioGRID, IntAct16497536 28514442 details
COP1_HUMANRBX1_HUMANBioGRID14739464 19295130 32041890 details
COP1_HUMANFOXO1_HUMANBioGRID18815134 details
COP1_HUMANCRTC2_HUMANBioGRID17805301 details
COP1_HUMANHSP7C_HUMANBioGRID16497536 details
COP1_HUMANHSP76_HUMANBioGRID16497536 details
COP1_HUMANHSP72_HUMANBioGRID16497536 details
COP1_HUMANTCPA_HUMANBioGRID16497536 details
COP1_HUMANTCPE_HUMANBioGRID16497536 details
COP1_HUMANTCPQ_HUMANBioGRID16497536 details
COP1_HUMANWDR5_HUMANBioGRID17041588 details
COP1_HUMANCSN2_HUMANBioGRID12466024 19295130 details
COP1_HUMANCSN8_HUMANBioGRID12466024 19295130 details
COP1_HUMANMDM2_HUMANBioGRID20333547 details
COP1_HUMANMDM4_HUMANBioGRID20333547 details
COP1_HUMANZN363_HUMANBioGRID20333547 details
COP1_HUMANPTN11_HUMANBioGRID23269672 details
COP1_HUMANREG1A_HUMANBioGRID23269672 details
COP1_HUMANSTAT3_HUMANBioGRID27820701 details
COP1_HUMANPLPL2_HUMANBioGRID27658392 details
COP1_HUMANCEBPA_HUMANBioGRID30692133 details
COP1_HUMANSIR1_HUMANBioGRID31125554 details
COP1_HUMANTPR_HUMANBioGRID32041890 details
COP1_HUMANFOXO4_HUMANBioGRID33101846 details