Entity Details

Primary name NPL4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8TAT6
EntryNameNPL4_HUMAN
FullNameNuclear protein localization protein 4 homolog
TaxID9606
Evidenceevidence at protein level
Length608
SequenceStatuscomplete
DateCreated2004-03-29
DateModified2021-06-02

Ontological Relatives

GenesNPLOC4

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007030 Golgi organization
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030970 retrograde protein transport, ER to cytosol
GO:0031625 ubiquitin protein ligase binding
GO:0032480 negative regulation of type I interferon production
GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex
GO:0036501 UFD1-NPL4 complex
GO:0039536 negative regulation of RIG-I signaling pathway
GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0070987 error-free translesion synthesis

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Nucleus

Domains

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DomainNameCategoryType
IPR001876 Zinc finger, RanBP2-typeDomainDomain
IPR007716 NPL4, zinc-binding putativeDomainDomain
IPR007717 Nuclear pore localisation protein NPL4, C-terminalDomainDomain
IPR016563 Nuclear protein localization protein 4FamilyFamily
IPR024682 Nuclear pore localisation protein Npl4, ubiquitin-like domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036443 Zinc finger, RanBP2-type superfamilyFamilyHomologous superfamily
IPR037518 MPN domainDomainDomain

Diseases

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Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
NPL4_HUMANUBC_HUMANBioGRID, MINT12644454 16196087 17070805 17550899 25752573 28190767 28525741 details
NPL4_HUMANTERA_HUMANBioGRID, DIP, IntAct, MINT15371428 16234241 17872946 18586029 18775313 20414249 21645854 23293021 23333620 26389662 26549226 27226613 27762274 27913212 28320958 28443643 29540532 29599191 30335548 30344098 31623962 32814053 details
NPL4_HUMANUFD1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11574150 15371428 16322459 17202270 18586029 18775313 20414249 21645854 22939629 24248593 26344197 26389662 28320958 32296183 details
NPL4_HUMANVP26B_HUMANBioGRID, IntAct32296183 details
NPL4_HUMANTGFR2_HUMANBioGRID, IntAct28443643 32814053 details
NPL4_HUMANGRAK_HUMANBioGRID20876349 details
NPL4_HUMANRAF1_HUMANBioGRID16364241 details
NPL4_HUMANM3K1_HUMANBioGRID25260751 details
NPL4_HUMANERPG3_HUMANBioGRID31722399 details
NPL4_HUMANERCC6_HUMANBioGRID31722399 details
NPL4_HUMANCDC42_HUMANBioGRID31478661 details
NPL4_HUMANFAF1_HUMANBioGRID, DIP, IntAct18775313 21645854 21914798 23293021 26389662 28443643 details
NPL4_HUMANSVIP_HUMANBioGRID17872946 details
NPL4_HUMANSELS_HUMANBioGRID17872946 details
NPL4_HUMANNSF1C_HUMANBioGRID18775313 26389662 details
NPL4_HUMANUBX11_HUMANBioGRID18775313 details
NPL4_HUMANASPC1_HUMANBioGRID18775313 26389662 details
NPL4_HUMANAMFR_HUMANBioGRID21636303 32614325 details
NPL4_HUMANSPRTN_HUMANBioGRID23042607 details
NPL4_HUMANUBXN6_HUMANBioGRID22337587 details
NPL4_HUMANIKBA_HUMANBioGRID24248593 details
NPL4_HUMANMPIP1_HUMANBioGRID24429874 details
NPL4_HUMANFBW1A_HUMANBioGRID24429874 details
NPL4_HUMANZFN2B_HUMANBioGRID24160817 details
NPL4_HUMANIFT74_HUMANBioGRID26389662 details
NPL4_HUMANIFT56_HUMANBioGRID26389662 details
NPL4_HUMANGLNA_HUMANBioGRID28320958 details
NPL4_HUMANSMUF1_HUMANBioGRID30335548 details
NPL4_HUMANDXO_HUMANBioGRID31164795 details
NPL4_HUMANST7_HUMANBioGRID29395067 details