Entity Details

Primary name B2CL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92843
EntryNameB2CL2_HUMAN
FullNameBcl-2-like protein 2
TaxID9606
Evidenceevidence at protein level
Length193
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesBCL2L2

GO terms

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GOName
GO:0005741 mitochondrial outer membrane
GO:0007283 spermatogenesis
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0046982 protein heterodimerization activity
GO:0097136 Bcl-2 family protein complex
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097718 disordered domain specific binding
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR002475 Bcl2-likeFamilyFamily
IPR003093 Apoptosis regulator, Bcl-2 protein, BH4DomainDomain
IPR013280 Apoptosis regulator, Bcl-WFamilyFamily
IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved siteSiteConserved site
IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved siteSiteConserved site
IPR020731 Apoptosis regulator, Bcl-2, BH4 motif, conserved siteSiteConserved site
IPR026298 Bcl-2 familyFamilyFamily
IPR036834 Bcl-2-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12340 NavitoclaxDrugbanksmall molecule

Interactions

65 interactions

InteractorPartnerSourcesPublicationsLink
B2CL2_HUMANB2L11_HUMANBioGRID, HPRD, IntAct15694340 16697956 17289999 21199865 28514442 32296183 9430630 9731710 details
B2CL2_HUMANBBC3_HUMANBioGRID, HPRD, IntAct15694340 16697956 28514442 details
B2CL2_HUMANBAD_HUMANBioGRID, DIP, HPRD, IntAct10381646 11483855 12115603 15694340 16697956 20603619 22000515 32296183 details
B2CL2_HUMANBIK_HUMANBioGRID, HPRD, IntAct10381646 15694340 16697956 25416956 27107012 30217970 32296183 details
B2CL2_HUMANHRK_HUMANBioGRID, HPRD, IntAct15694340 details
B2CL2_HUMANBID_HUMANBioGRID, HPRD, IntAct15694340 16697956 17289999 28514442 details
B2CL2_HUMANAPR_HUMANIntAct15694340 details
B2CL2_HUMANASPP2_HUMANDIP, MINT18448430 18719108 details
B2CL2_HUMANBAX_HUMANBioGRID, DIP, IntAct10381646 17289999 18981409 21199865 25115399 28514442 details
B2CL2_HUMANBAK_HUMANBioGRID, IntAct10381646 25115399 25416956 32296183 details
B2CL2_HUMANITF2_HUMANBioGRID, IntAct25416956 details
B2CL2_HUMANKASH5_HUMANBioGRID, IntAct25416956 27107012 32296183 details
B2CL2_HUMANFATE1_HUMANBioGRID, IntAct25416956 32296183 details
B2CL2_HUMANBMF_HUMANBioGRID, HPRD, IntAct11546872 25416956 32296183 details
B2CL2_HUMANTEX11_HUMANBioGRID, IntAct27107012 details
B2CL2_HUMANS100B_HUMANBioGRID, IntAct27107012 details
B2CL2_HUMANIKZF1_HUMANIntAct27107012 details
B2CL2_HUMANT179B_HUMANIntAct32296183 details
B2CL2_HUMANLRP10_HUMANIntAct32296183 details
B2CL2_HUMANSAR1A_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANFGF14_HUMANIntAct32296183 details
B2CL2_HUMANRHBD2_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANERGI3_HUMANIntAct32296183 details
B2CL2_HUMANBNIP5_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANS39A6_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANSYCY2_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANGPX8_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANG0S2_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANATP5J_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANS35C2_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANMUC1_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANCD79A_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANCISD2_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANGP151_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANTMX1_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANSTOM_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANCJ067_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANCHODL_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANAPOC1_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANSGPL1_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANGORAB_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANTM139_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANSUSD3_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANANKS6_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANS35E3_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANS39A2_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANKCNJ6_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANPANX1_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANCLD7_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANBHA09_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANAPOC4_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANCIDEB_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANMGST2_HUMANBioGRID, IntAct32296183 details
B2CL2_HUMANB2CL2_HUMANDIP22000515 details
B2CL2_HUMANPP1A_HUMANBioGRID, HPRD12115603 details
B2CL2_HUMANP53_HUMANBioGRID24491548 25115399 details
B2CL2_HUMANLMNA_HUMANBioGRID24623722 details
B2CL2_HUMANBNIP3_HUMANBioGRID30217970 details
B2CL2_HUMANLRIQ1_HUMANBioGRID32296183 details
B2CL2_HUMANPSCA_HUMANBioGRID32296183 details
B2CL2_HUMANAPOC2_HUMANBioGRID32296183 details
B2CL2_HUMANBOP_HUMANIntAct23055042 details
B2CL2_HUMANPRKN_HUMANBioGRID24999239 details
B2CL2_HUMANPINK1_HUMANBioGRID24999239 details
B2CL2_HUMANBBC3B_HUMANBioGRID, HPRD15694340 16697956 28514442 details