Entity Details

Primary name DHX58_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96C10
EntryNameDHX58_HUMAN
FullNameProbable ATP-dependent RNA helicase DHX58
TaxID9606
Evidenceevidence at protein level
Length678
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesDHX58

GO terms

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GOName
GO:0003677 DNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0008270 zinc ion binding
GO:0009615 response to virus
GO:0009617 response to bacterium
GO:0016032 viral process
GO:0016787 hydrolase activity
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032728 positive regulation of interferon-beta production
GO:0039534 negative regulation of MDA-5 signaling pathway
GO:0039536 negative regulation of RIG-I signaling pathway
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0045824 negative regulation of innate immune response
GO:0051607 defense response to virus
GO:1900245 positive regulation of MDA-5 signaling pathway
GO:1900246 positive regulation of RIG-I signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR021673 RIG-I-like receptor, C-terminal regulatory domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR038557 RIG-I-like receptor, C-terminal domain superfamilyFamilyHomologous superfamily
IPR041204 RIG-I receptor, C-terminalDomainDomain

Diseases

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