Entity Details

Primary name VPS11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H270
EntryNameVPS11_HUMAN
FullNameVacuolar protein sorting-associated protein 11 homolog
TaxID9606
Evidenceevidence at protein level
Length941
SequenceStatuscomplete
DateCreated2002-09-19
DateModified2021-06-02

Ontological Relatives

GenesVPS11

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0006886 intracellular protein transport
GO:0006904 vesicle docking involved in exocytosis
GO:0006914 autophagy
GO:0007032 endosome organization
GO:0007033 vacuole organization
GO:0008333 endosome to lysosome transport
GO:0016567 protein ubiquitination
GO:0019904 protein domain specific binding
GO:0019905 syntaxin binding
GO:0030136 clathrin-coated vesicle
GO:0030139 endocytic vesicle
GO:0030674 protein-macromolecule adaptor activity
GO:0030897 HOPS complex
GO:0031647 regulation of protein stability
GO:0031902 late endosome membrane
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0034058 endosomal vesicle fusion
GO:0035542 regulation of SNARE complex assembly
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
GO:1902115 regulation of organelle assembly
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:2000643 positive regulation of early endosome to late endosome transport

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Early endosome
Endosome
Late endosome membrane
Lysosome membrane

Domains

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DomainNameCategoryType
IPR000547 Clathrin, heavy chain/VPS, 7-fold repeatRepeatRepeat
IPR001841 Zinc finger, RING-typeDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR016528 Vacuolar protein sorting-associated protein 11FamilyFamily
IPR024763 Vacuolar protein sorting protein 11, C-terminalDomainDomain
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
VPS11_HUMANLSM1_HUMANBioGRID, HPRD, IntAct15231747 details
VPS11_HUMANBCAR1_HUMANBioGRID, HPRD, IntAct16169070 details
VPS11_HUMANMARK3_HUMANBioGRID, HPRD, IntAct16169070 details
VPS11_HUMANAP2B_HUMANHPRD, IntAct16169070 details
VPS11_HUMANTS101_HUMANBioGRID, IntAct19549727 details
VPS11_HUMANUBE2U_HUMANBioGRID, IntAct19549727 details
VPS11_HUMANMON1B_HUMANBioGRID, IntAct20434987 details
VPS11_HUMANBMI1_HUMANBioGRID, IntAct22493164 details
VPS11_HUMANTRI32_HUMANBioGRID, IntAct22493164 details
VPS11_HUMANRN181_HUMANBioGRID, IntAct22493164 details
VPS11_HUMANLRSM1_HUMANBioGRID, IntAct22493164 details
VPS11_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
VPS11_HUMANVPS18_HUMANBioGRID, HPRD, IntAct, UniProt11382755 23901104 25783203 26186194 26496610 28514442 28931724 details
VPS11_HUMANVPS39_HUMANBioGRID, IntAct22939629 23901104 26186194 26463206 28514442 32296183 33422265 details
VPS11_HUMANVPS16_HUMANBioGRID, HPRD, IntAct, UniProt11382755 23901104 26463206 26496610 details
VPS11_HUMANKR108_HUMANBioGRID, IntAct25416956 32296183 details
VPS11_HUMANRILP_HUMANBioGRID, UniProt25445562 details
VPS11_HUMANCLAT_HUMANIntAct32814053 details
VPS11_HUMANFGFR3_HUMANIntAct32814053 details
VPS11_HUMANGELS_HUMANIntAct32814053 details
VPS11_HUMANUBE2K_HUMANIntAct32814053 details
VPS11_HUMANRASH_HUMANIntAct32814053 details
VPS11_HUMANPECA1_HUMANIntAct32814053 details
VPS11_HUMANVIME_HUMANIntAct32814053 details
VPS11_HUMANKLF11_HUMANIntAct32814053 details
VPS11_HUMANDNJB6_HUMANIntAct32814053 details
VPS11_HUMANSPRE1_HUMANIntAct32814053 details
VPS11_HUMANA4_HUMANIntAct32814053 details
VPS11_HUMANGGA3_HUMANBioGRID16996030 details
VPS11_HUMANKR103_HUMANBioGRID25416956 details
VPS11_HUMANEZRI_HUMANBioGRID21148287 details
VPS11_HUMANRADI_HUMANBioGRID21148287 details
VPS11_HUMANMOES_HUMANBioGRID21148287 details
VPS11_HUMANRAB7A_HUMANBioGRID25445562 details
VPS11_HUMANUB2L3_HUMANBioGRID29643511 details
VPS11_HUMANUB2D2_HUMANBioGRID29643511 details
VPS11_HUMANSTX1A_HUMANBioGRID, HPRD14623309 17027648 details
VPS11_HUMANSTX7_HUMANBioGRID, HPRD, UniProt11382755 details
VPS11_HUMANVPS8_HUMANBioGRID, IntAct26463206 26496610 28931724 details
VPS11_HUMANTGFA1_HUMANBioGRID, IntAct, UniProt25266290 26186194 26463206 26496610 28514442 details
VPS11_HUMANVP33A_HUMANBioGRID, HPRD, IntAct, MINT11382755 26463206 26496610 29778605 details
VPS11_HUMANSTX17_HUMANBioGRID, UniProt24554770 details
VPS11_HUMANVPS41_HUMANBioGRID, IntAct26186194 26463206 28514442 28931724 33422265 details
VPS11_HUMANUVRAG_HUMANBioGRID, HPRD18552835 details
VPS11_HUMANEDNRA_HUMANBioGRID9645692 details
VPS11_HUMANSTX6_HUMANHPRD14623309 details
VPS11_HUMANSTX8_HUMANHPRD14623309 details
VPS11_HUMANVPS45_HUMANHPRD14623309 details