Entity Details

Primary name COX2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00403
EntryNameCOX2_HUMAN
FullNameCytochrome c oxidase subunit 2
TaxID9606
Evidenceevidence at protein level
Length227
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesCOX2

GO terms

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GOName
GO:0004129 cytochrome-c oxidase activity
GO:0005507 copper ion binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
GO:0007595 lactation
GO:0009409 response to cold
GO:0010729 positive regulation of hydrogen peroxide biosynthetic process
GO:0010940 positive regulation of necrotic cell death
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042773 ATP synthesis coupled electron transport
GO:0045277 respiratory chain complex IV
GO:2001171 positive regulation of ATP biosynthetic process

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001505 Copper centre Cu(A)SiteBinding site
IPR002429 Cytochrome c oxidase subunit II-like C-terminalDomainDomain
IPR008972 CupredoxinFamilyHomologous superfamily
IPR011759 Cytochrome C oxidase subunit II, transmembrane domainDomainDomain
IPR014222 Cytochrome c oxidase, subunit IIDomainDomain
IPR034210 Cytochrome c oxidase subunit 2, C-terminalDomainDomain
IPR036257 Cytochrome C oxidase subunit II, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB02659 Cholic AcidDrugbanksmall molecule
DB04464 N-FormylmethionineDrugbanksmall molecule
DB05412 TalmapimodDrugbanksmall molecule