Entity Details

Primary name RU17_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08621
EntryNameRU17_HUMAN
FullNameU1 small nuclear ribonucleoprotein 70 kDa
TaxID9606
Evidenceevidence at protein level
Length437
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesSNRNP70

GO terms

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GOName
GO:0000398 mRNA splicing, via spliceosome
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0016607 nuclear speck
GO:0017069 snRNA binding
GO:0030619 U1 snRNA binding
GO:0043462 regulation of ATPase activity
GO:0043484 regulation of RNA splicing
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0061084 negative regulation of protein refolding
GO:0071004 U2-type prespliceosome
GO:1904715 negative regulation of chaperone-mediated autophagy

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000504 RNA recognition motif domainDomainDomain
IPR012677 Nucleotide-binding alpha-beta plait domain superfamilyFamilyHomologous superfamily
IPR022023 U1 small nuclear ribonucleoprotein of 70kDa N-terminalDomainDomain
IPR034143 snRNP70, RNA recognition motifDomainDomain
IPR035979 RNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

81 interactions

InteractorPartnerSourcesPublicationsLink
RU17_HUMANRNF11_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANSMAD2_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANSMAD3_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANKPCD2_HUMANBioGRID, MINT15231748 details
RU17_HUMANSMUF2_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANSMAD5_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANPR40A_HUMANBioGRID, HPRD, MINT15231748 26344197 29802200 details
RU17_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANSMAD4_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANSMAD1_HUMANBioGRID, HPRD, MINT15231748 details
RU17_HUMANWBP4_HUMANBioGRID, MINT16055720 details
RU17_HUMANCEP63_HUMANBioGRID, IntAct17043677 31413325 details
RU17_HUMANSMN_HUMANBioGRID, DIP, IntAct, MINT19928837 24981860 26828962 28514442 29802200 details
RU17_HUMANMYC_HUMANBioGRID, IntAct20195357 details
RU17_HUMANCLK2_HUMANBioGRID, IntAct21988832 28514442 32296183 details
RU17_HUMANRGRF1_HUMANBioGRID, IntAct21988832 details
RU17_HUMANTF65_HUMANBioGRID, IntAct21988832 details
RU17_HUMANCDKL3_HUMANBioGRID, IntAct21988832 details
RU17_HUMANCSK21_HUMANBioGRID, IntAct22113938 29802200 details
RU17_HUMANCHERP_HUMANBioGRID, MINT22365833 29802200 details
RU17_HUMANANM5_HUMANBioGRID, MINT22365833 details
RU17_HUMANSRPK2_HUMANBioGRID, IntAct, MINT22365833 23602568 26167880 28514442 29802200 9472028 details
RU17_HUMANSRPK1_HUMANBioGRID, HPRD, IntAct12417631 23602568 29802200 9472028 details
RU17_HUMANSRRM4_HUMANBioGRID, IntAct32296183 details
RU17_HUMANGTPB2_HUMANBioGRID, IntAct32296183 details
RU17_HUMANSCAFB_HUMANBioGRID, HPRD, IntAct28514442 9447963 details
RU17_HUMANSRSF1_HUMANBioGRID, HPRD, IntAct, UniProt18559666 28514442 29802200 9685421 9799243 details
RU17_HUMANGEMI2_HUMANBioGRID, DIP, HPRD, IntAct24981860 26828962 28514442 29802200 9447963 details
RU17_HUMANPPM1G_HUMANDIP17572683 details
RU17_HUMANSRSF2_HUMANBioGRID, HPRD, UniProt18559666 29802200 8261509 details
RU17_HUMANSRSF3_HUMANBioGRID, UniProt18559666 26344197 29802200 details
RU17_HUMANCPSF5_HUMANBioGRID, HPRD14561889 29802200 details
RU17_HUMANZRAB2_HUMANBioGRID, HPRD11448987 29802200 details
RU17_HUMANLRP1_HUMANBioGRID20205790 details
RU17_HUMANSHBG_HUMANBioGRID15862967 details
RU17_HUMANTOP1_HUMANBioGRID12549820 29802200 details
RU17_HUMANA4_HUMANBioGRID21244100 21832049 details
RU17_HUMANIL32_HUMANBioGRID25178676 details
RU17_HUMANRU17_HUMANBioGRID29802200 details
RU17_HUMANCASP3_HUMANBioGRID8642305 details
RU17_HUMANCDC42_HUMANBioGRID31478661 details
RU17_HUMANOGT1_HUMANBioGRID32994395 details
RU17_HUMANARSF_HUMANHPRD9685421 details
RU17_HUMANSF3A2_HUMANBioGRID, MINT17332742 details
RU17_HUMANSFPQ_HUMANBioGRID, I2D11514619 29802200 details
RU17_HUMANCUL1_HUMANBioGRID, IntAct11850407 21145461 details
RU17_HUMANSNRPA_HUMANBioGRID, IntAct28514442 29802200 details
RU17_HUMANSMD1_HUMANBioGRID, DIP, IntAct22939629 26344197 26828962 28514442 29802200 details
RU17_HUMANRU1C_HUMANBioGRID, HPRD, IntAct28514442 29802200 29884807 9826776 details
RU17_HUMANSRS10_HUMANBioGRID, HPRD, IntAct14765198 28514442 29802200 details
RU17_HUMANCD2AP_HUMANIntAct31413325 details
RU17_HUMANEPHA1_HUMANIntAct31413325 details
RU17_HUMANFERM2_HUMANIntAct31413325 details
RU17_HUMANCELF1_HUMANIntAct31413325 details
RU17_HUMANKHDR1_HUMANBioGRID, IntAct29802200 31413325 details
RU17_HUMANUBAC1_HUMANIntAct31413325 details
RU17_HUMANEPHA4_HUMANIntAct31413325 details
RU17_HUMANPICK1_HUMANIntAct31413325 details
RU17_HUMANPICAL_HUMANIntAct31413325 details
RU17_HUMANOBI1_HUMANIntAct31413325 details
RU17_HUMANM4A6A_HUMANIntAct31413325 details
RU17_HUMANCASS4_HUMANIntAct31413325 details
RU17_HUMANTREM2_HUMANIntAct31413325 details
RU17_HUMANTAU_HUMANBioGRID, IntAct29802200 31413325 details
RU17_HUMANAPOE_HUMANIntAct31413325 details
RU17_HUMANPACN1_HUMANIntAct31413325 details
RU17_HUMANFYN_HUMANIntAct31413325 details
RU17_HUMANTIA1_HUMANIntAct12486009 details
RU17_HUMANDDX17_HUMANBioGRID12193588 29802200 details
RU17_HUMANCRP_HUMANBioGRID, HPRD2477447 details
RU17_HUMANFBW1A_HUMANBioGRID11850407 details
RU17_HUMANSKP1_HUMANBioGRID11850407 details
RU17_HUMANTERF2_HUMANBioGRID20811636 details
RU17_HUMANU2AF2_HUMANBioGRID22939629 26641092 29802200 details
RU17_HUMANROA2_HUMANBioGRID, HPRD1833625 29802200 details
RU17_HUMANTADBP_HUMANBioGRID29802200 details
RU17_HUMANHTSF1_HUMANBioGRID, HPRD11780068 29802200 details
RU17_HUMANLC7L3_HUMANBioGRID29802200 details
RU17_HUMANRBM25_HUMANBioGRID29802200 details
RU17_HUMANCTDP1_HUMANHPRD12560496 details