Entity Details

Primary name ITB4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16144
EntryNameITB4_HUMAN
FullNameIntegrin beta-4
TaxID9606
Evidenceevidence at protein level
Length1822
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesITGB4

GO terms

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GOName
GO:0001664 G protein-coupled receptor binding
GO:0005178 integrin binding
GO:0005604 basement membrane
GO:0005730 nucleolus
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006914 autophagy
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008305 integrin complex
GO:0009611 response to wounding
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0016477 cell migration
GO:0030054 cell junction
GO:0030056 hemidesmosome
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0031252 cell leading edge
GO:0031581 hemidesmosome assembly
GO:0031965 nuclear membrane
GO:0032290 peripheral nervous system myelin formation
GO:0033627 cell adhesion mediated by integrin
GO:0035878 nail development
GO:0043235 receptor complex
GO:0043589 skin morphogenesis
GO:0046847 filopodium assembly
GO:0048333 mesodermal cell differentiation
GO:0048870 cell motility
GO:0061450 trophoblast cell migration
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR003644 Na-Ca exchanger/integrin-beta4DomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR012013 Integrin beta-4 subunitFamilyFamily
IPR012896 Integrin beta subunit, tailDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR033760 Integrin beta N-terminalDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR038081 CalX-like domain superfamilyFamilyHomologous superfamily
IPR040622 Integrin beta, epidermal growth factor-like domain 1DomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB05122 R1295Drugbanksmall molecule

Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
ITB4_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 details
ITB4_HUMANLOX12_HUMANBioGRID, HPRD, IntAct10727209 26037302 details
ITB4_HUMANPLEC_HUMANBioGRID, HPRD, MINT11328943 14668477 19242489 22939629 details
ITB4_HUMANSRBP2_HUMANBioGRID, IntAct20936779 details
ITB4_HUMANAP2C_HUMANIntAct24835590 details
ITB4_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANTRIM1_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANMTUS2_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANTGM1_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKR123_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANNT2NC_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKR109_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANECM1_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKRA42_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANMDFI_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANK1C40_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKRA93_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKR108_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKRA92_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKRA24_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANTRIP6_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANATL4_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANMYF5_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANOBF1_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKR151_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKR107_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANKR171_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANPLS4_HUMANBioGRID, IntAct32296183 details
ITB4_HUMANX3CL1_HUMANIntAct24789099 details
ITB4_HUMANSHC1_HUMANBioGRID, HPRD11044453 details
ITB4_HUMANIF6_HUMANBioGRID, HPRD9374518 details
ITB4_HUMANERBIN_HUMANBioGRID, HPRD11375975 details
ITB4_HUMANCOHA1_HUMANBioGRID, HPRD14668477 9500991 9660880 details
ITB4_HUMANDYST_HUMANBioGRID, HPRD10637308 14668477 details
ITB4_HUMANSDC1_HUMANBioGRID20181947 details
ITB4_HUMANSDC2_HUMANBioGRID20181947 details
ITB4_HUMANSDC3_HUMANBioGRID20181947 details
ITB4_HUMANKRA23_HUMANBioGRID32296183 details
ITB4_HUMANKRA13_HUMANBioGRID32296183 details
ITB4_HUMANNT2NA_HUMANBioGRID32296183 details
ITB4_HUMAN1433T_HUMANHPRD12919677 details
ITB4_HUMAN1433B_HUMANHPRD12919677 details
ITB4_HUMANFLNA_HUMANMINT15225631 details
ITB4_HUMANITA6_HUMANHPRD, IntAct21880726 2649503 9660880 details
ITB4_HUMANARRD3_HUMANBioGRID, I2D20603614 details
ITB4_HUMANFABPH_HUMANI2D20802519 details
ITB4_HUMANCADM1_HUMANIntAct21880726 details
ITB4_HUMANS1PR2_HUMANIntAct24851274 details
ITB4_HUMANS1PR3_HUMANIntAct24851274 details
ITB4_HUMANFAK1_HUMANMINT27178753 details
ITB4_HUMANCD151_HUMANIntAct10811835 details
ITB4_HUMANITA3_HUMANBioGRID16878156 details
ITB4_HUMANENPP2_HUMANBioGRID21696367 details
ITB4_HUMANLPAR1_HUMANBioGRID21696367 details
ITB4_HUMANSE1L1_HUMANBioGRID24324549 details
ITB4_HUMANMUC5A_HUMANBioGRID26751774 details
ITB4_HUMANTGM2_HUMANBioGRID27780825 details
ITB4_HUMANGRB2_HUMANHPRD9171350 details
ITB4_HUMANFYN_HUMANHPRD11684709 details
ITB4_HUMANMET_HUMANHPRD11733063 14602071 details
ITB4_HUMANYES_HUMANHPRD11684709 details
ITB4_HUMANKPCA_HUMANHPRD10477766 12919677 15121854 details
ITB4_HUMANVIME_HUMANHPRD12441134 details
ITB4_HUMANCLCA1_HUMANHPRD12110680 14512419 details
ITB4_HUMANCLCA2_HUMANHPRD12110680 14512419 details
ITB4_HUMANERBB2_HUMANHPRD11375975 details
ITB4_HUMANKPCD_HUMANHPRD11389095 details