Entity Details

Primary name IBP4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22692
EntryNameIBP4_HUMAN
FullNameInsulin-like growth factor-binding protein 4
TaxID9606
Evidenceevidence at protein level
Length258
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesIGFBP4

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005788 endoplasmic reticulum lumen
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0010906 regulation of glucose metabolic process
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
GO:0043410 positive regulation of MAPK cascade
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044342 type B pancreatic cell proliferation
GO:0090090 negative regulation of canonical Wnt signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000716 Thyroglobulin type-1DomainDomain
IPR000867 Insulin-like growth factor-binding protein, IGFBPDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved siteSiteConserved site
IPR022321 Insulin-like growth factor-binding protein family 1-6, chordataFamilyFamily
IPR022327 Insulin-like growth factor-binding protein 4FamilyFamily
IPR036857 Thyroglobulin type-1 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01277 MecaserminDrugbankbiotech