Entity Details

Primary name DGKA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23743
EntryNameDGKA_HUMAN
FullNameDiacylglycerol kinase alpha
TaxID9606
Evidenceevidence at protein level
Length735
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesDGKA

GO terms

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GOName
GO:0003951 NAD+ kinase activity
GO:0004143 diacylglycerol kinase activity
GO:0005509 calcium ion binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006654 phosphatidic acid biosynthetic process
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0008289 lipid binding
GO:0016020 membrane
GO:0016301 kinase activity
GO:0030168 platelet activation
GO:0035556 intracellular signal transduction
GO:0046339 diacylglycerol metabolic process
GO:0046486 glycerolipid metabolic process
GO:0046834 lipid phosphorylation

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000756 Diacylglycerol kinase, accessory domainDomainDomain
IPR001206 Diacylglycerol kinase, catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamilyFamilyHomologous superfamily
IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminalFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR029477 Diacylglycerol kinase type I, N-terminalDomainDomain
IPR037607 Diacylglycerol kinaseFamilyFamily
IPR038199 DGK type I, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00163 Vitamin EDrugbanksmall molecule
DB14001 alpha-Tocopherol succinateDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
DGKA_HUMANSREK1_HUMANHPRD14559993 details
DGKA_HUMANSRC_HUMANHPRD, MINT15122338 17700527 details
DGKA_HUMANIL21_HUMANBioGRID, HPRD, IntAct25241761 8626603 details