Entity Details

Primary name ATPA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25705
EntryNameATPA_HUMAN
FullNameATP synthase subunit alpha, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length553
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesATP5F1A

GO terms

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GOName
GO:0001937 negative regulation of endothelial cell proliferation
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0005759 mitochondrial matrix
GO:0005886 plasma membrane
GO:0006629 lipid metabolic process
GO:0006754 ATP biosynthetic process
GO:0015986 ATP synthesis coupled proton transport
GO:0016020 membrane
GO:0042288 MHC class I protein binding
GO:0042407 cristae formation
GO:0042776 mitochondrial ATP synthesis coupled proton transport
GO:0043531 ADP binding
GO:0043532 angiostatin binding
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cell membrane
Mitochondrion
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domainDomainDomain
IPR000793 ATP synthase, alpha subunit, C-terminalDomainDomain
IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domainDomainDomain
IPR005294 ATP synthase, F1 complex, alpha subunitFamilyFamily
IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active siteSiteActive site
IPR023366 ATP synthase subunit alpha, N-terminal domain-like superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR033732 ATP synthase, F1 complex, alpha subunit nucleotide-binding domainDomainDomain
IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamilyFamilyHomologous superfamily
IPR038376 ATP synthase, alpha subunit, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615228 OMIMMitochondrial complex V deficiency, nuclear type 4 (MC5DN4)A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. The disease is caused by variants affecting the gene represented in this entry.
616045 OMIMCombined oxidative phosphorylation deficiency 22 (COXPD22)A mitochondrial disorder characterized by intrauterine growth retardation, microcephaly, hypotonia, pulmonary hypertension, failure to thrive, encephalopathy, and heart failure. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04216 QuercetinDrugbanksmall molecule
DB07384 1-ACETYL-2-CARBOXYPIPERIDINEDrugbanksmall molecule
DB07394 AUROVERTIN BDrugbanksmall molecule
DB08399 PiceatannolDrugbanksmall molecule
DB08629 N1-(2-AMINO-4-METHYLPENTYL)OCTAHYDRO-PYRROLO[1,2-A] PYRIMIDINEDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
ATPA_HUMANATPF2_HUMANBioGRID, HPRD, IntAct11410595 27499296 details
ATPA_HUMANKS6B2_HUMANBioGRID, IntAct21988832 25324306 details
ATPA_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
ATPA_HUMANAP2A_HUMANIntAct24835590 details
ATPA_HUMANHSPB2_HUMANbhf-ucl, BioGRID26465331 details
ATPA_HUMANATPB_HUMANBioGRID, IntAct22939629 25416956 26344197 27499296 28514442 30021884 31536960 details
ATPA_HUMANNPSR1_HUMANBioGRID, MINT28298427 details
ATPA_HUMANA4_HUMANBioGRID, UniProt21832049 30664241 details
ATPA_HUMANHD_HUMANIntAct32814053 details
ATPA_HUMAN1433T_HUMANBioGRID15161933 20618440 details
ATPA_HUMANSHBG_HUMANBioGRID, HPRD15862967 details
ATPA_HUMANPTEN_HUMANBioGRID26561776 details
ATPA_HUMANHCD2_HUMANBioGRID22496890 details
ATPA_HUMANMRP1_HUMANBioGRID22188235 details
ATPA_HUMANSNF5_HUMANBioGRID27229929 details
ATPA_HUMANPTPRF_HUMANBioGRID25458010 details
ATPA_HUMANSEGN_HUMANBioGRID21528130 details
ATPA_HUMANOGT1_HUMANBioGRID32994395 details
ATPA_HUMANM3K3_HUMANIntAct14743216 details
ATPA_HUMANM3K14_HUMANIntAct14743216 details
ATPA_HUMANTF65_HUMANIntAct14743216 details
ATPA_HUMANTBK1_HUMANIntAct14743216 details
ATPA_HUMANTNR1A_HUMANIntAct14743216 details
ATPA_HUMANTNR1B_HUMANIntAct14743216 details
ATPA_HUMAN1433Z_HUMANBioGRID, HPRD, MINT15161933 15324660 20618440 details
ATPA_HUMANSIR3_HUMANBioGRID, IntAct19343720 31108370 details
ATPA_HUMANBL1S1_HUMANUniProt22309213 details
ATPA_HUMANATPG_HUMANBioGRID, HPRD, IntAct22939629 26344197 27499296 8065448 details
ATPA_HUMANGDAS1_HUMANIntAct30021884 details
ATPA_HUMANMLH1_HUMANBioGRID17148452 details
ATPA_HUMANPSMD4_HUMANBioGRID12601813 details
ATPA_HUMANHDAC5_HUMANBioGRID21081666 details
ATPA_HUMANRN146_HUMANBioGRID21825151 details
ATPA_HUMANSH3K1_HUMANBioGRID19531213 details
ATPA_HUMANISG15_HUMANBioGRID16009940 33024031 details
ATPA_HUMANCAH9_HUMANBioGRID23181366 details
ATPA_HUMANPARP1_HUMANBioGRID24140708 details
ATPA_HUMANSPRTN_HUMANBioGRID23254330 details
ATPA_HUMANADX_HUMANBioGRID20547883 details
ATPA_HUMANFACD2_HUMANBioGRID28687786 31180492 details
ATPA_HUMANCETN3_HUMANBioGRID30251372 details
ATPA_HUMANAIMP1_HUMANHPRD11741979 details