Entity Details

Primary name DCK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP27707
EntryNameDCK_HUMAN
FullNameDeoxycytidine kinase
TaxID9606
Evidenceevidence at protein level
Length260
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesDCK

GO terms

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GOName
GO:0004136 deoxyadenosine kinase activity
GO:0004137 deoxycytidine kinase activity
GO:0004138 deoxyguanosine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006220 pyrimidine nucleotide metabolic process
GO:0008144 drug binding
GO:0019136 deoxynucleoside kinase activity
GO:0042803 protein homodimerization activity
GO:0043097 pyrimidine nucleoside salvage
GO:0043101 purine-containing compound salvage

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR002624 Deoxynucleoside kinaseFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR031314 Deoxynucleoside kinase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00242 CladribineDrugbanksmall molecule
DB00441 GemcitabineDrugbanksmall molecule
DB00631 ClofarabineDrugbanksmall molecule
DB00642 PemetrexedDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00879 EmtricitabineDrugbanksmall molecule
DB00943 ZalcitabineDrugbanksmall molecule
DB00987 CytarabineDrugbanksmall molecule
DB01073 FludarabineDrugbanksmall molecule
DB01262 DecitabineDrugbanksmall molecule
DB01280 NelarabineDrugbanksmall molecule
DB02594 2'-DeoxycytidineDrugbanksmall molecule
DB04961 TroxacitabineSwissprotsmall molecule
DB05494 ElacytarabineDrugbanksmall molecule

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
DCK_HUMANMED19_HUMANBioGRID, HPRD, IntAct16169070 details
DCK_HUMANDD19B_HUMANBioGRID, HPRD, IntAct16169070 details
DCK_HUMANGOLM1_HUMANBioGRID, HPRD, IntAct16169070 details
DCK_HUMANTFEC_HUMANBioGRID, IntAct21988832 details
DCK_HUMANDCK_HUMANBioGRID, MINT21900206 details
DCK_HUMANRXRG_HUMANBioGRID, MINT21900206 details