Entity Details

Primary name GCYB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02153
EntryNameGCYB1_HUMAN
FullNameGuanylate cyclase soluble subunit beta-1
TaxID9606
Evidenceevidence at protein level
Length619
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesGUCY1B1

GO terms

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GOName
GO:0004383 guanylate cyclase activity
GO:0005525 GTP binding
GO:0006182 cGMP biosynthetic process
GO:0007263 nitric oxide mediated signal transduction
GO:0008015 blood circulation
GO:0008074 guanylate cyclase complex, soluble
GO:0019934 cGMP-mediated signaling
GO:0020037 heme binding
GO:0038023 signaling receptor activity
GO:0038060 nitric oxide-cGMP-mediated signaling pathway
GO:0046872 metal ion binding
GO:0048786 presynaptic active zone
GO:0071732 cellular response to nitric oxide
GO:0099555 trans-synaptic signaling by nitric oxide, modulating synaptic transmission

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclaseDomainDomain
IPR011644 Heme NO-bindingDomainDomain
IPR011645 Haem NO binding associatedDomainDomain
IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved siteSiteConserved site
IPR024096 NO signalling/Golgi transport ligand-binding domain superfamilyFamilyHomologous superfamily
IPR029787 Nucleotide cyclaseFamilyHomologous superfamily
IPR038158 H-NOX domain superfamilyFamilyHomologous superfamily
IPR042463 Haem NO binding associated domain superfamilyFamilyHomologous superfamily

Diseases

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