Entity Details

Primary name ABR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12979
EntryNameABR_HUMAN
FullNameActive breakpoint cluster region-related protein
TaxID9606
Evidenceevidence at protein level
Length859
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesABR

GO terms

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GOName
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005829 cytosol
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0016020 membrane
GO:0030424 axon
GO:0043065 positive regulation of apoptotic process
GO:0043197 dendritic spine
GO:0050804 modulation of chemical synaptic transmission
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0090630 activation of GTPase activity
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse

Subcellular Location

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Subcellular Location
Cell junction
Cell projection

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001849 Pleckstrin homology domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR037769 Abr/BcrFamilyFamily
IPR037865 Active breakpoint cluster region-related protein, PH domainDomainDomain

Diseases

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