Entity Details

Primary name SYK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15046
EntryNameSYK_HUMAN
FullNameLysine--tRNA ligase
TaxID9606
Evidenceevidence at protein level
Length597
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesKARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0002276 basophil activation involved in immune response
GO:0002863 positive regulation of inflammatory response to antigenic stimulus
GO:0003877 ATP adenylyltransferase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
GO:0008033 tRNA processing
GO:0010165 response to X-ray
GO:0015966 diadenosine tetraphosphate biosynthetic process
GO:0016032 viral process
GO:0016597 amino acid binding
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043032 positive regulation of macrophage activation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0070371 ERK1 and ERK2 cascade

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Mitochondrion
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR002313 Lysine-tRNA ligase, class IIFamilyFamily
IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)DomainDomain
IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-typeDomainDomain
IPR006195 Aminoacyl-tRNA synthetase, class IIDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR018149 Lysyl-tRNA synthetase, class II, C-terminalDomainDomain
IPR034762 Bacterial/eukaryotic lysine-tRNA ligase, class IIFamilyFamily
IPR044136 Lysine-tRNA ligase, class II, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00123 L-LysineDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
SYK_HUMANEF1G_HUMANBioGRID, HPRD, IntAct16169070 details
SYK_HUMANLIS1_HUMANBioGRID, HPRD, IntAct16169070 details
SYK_HUMANADT3_HUMANBioGRID, HPRD, IntAct16169070 details
SYK_HUMANFRS3_HUMANHPRD, IntAct16169070 details
SYK_HUMANAIMP2_HUMANBioGRID, DIP, HPRD, IntAct, MINT12819782 16189514 19584093 21536907 21900206 21988832 22751010 22939629 24212136 25416956 26264872 26344197 28514442 29997244 31116475 31792442 32296183 32814053 9878398 details
SYK_HUMANG3P_HUMANBioGRID, MINT21900206 details
SYK_HUMANP55G_HUMANBioGRID, MINT21900206 details
SYK_HUMANVIME_HUMANBioGRID, MINT21900206 details
SYK_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
SYK_HUMANRSSA_HUMANBioGRID, DIP, MINT22751010 24212136 24983501 details
SYK_HUMANLAMB1_HUMANMINT24983501 details
SYK_HUMANSYK_HUMANDIP18272479 21536907 24212136 details
SYK_HUMANSODC_HUMANHPRD, IntAct18715867 32814053 details
SYK_HUMANSYDM_HUMANBioGRID26344197 9878398 details
SYK_HUMANMK01_HUMANBioGRID22751010 details
SYK_HUMANESR1_HUMANBioGRID20348541 details
SYK_HUMANSPTN1_HUMANBioGRID17607528 details
SYK_HUMANCDC42_HUMANBioGRID31478661 details
SYK_HUMANSUMO2_HUMANBioGRID32786267 details
SYK_HUMANOGT1_HUMANBioGRID32994395 details
SYK_HUMANGEMI4_HUMANHPRD12869526 details
SYK_HUMANEF1D_HUMANHPRD11829477 details
SYK_HUMANTANK_HUMANIntAct14743216 details
SYK_HUMANIKKE_HUMANIntAct17353931 details
SYK_HUMANSYEP_HUMANBioGRID, DIP, IntAct21220307 22386318 22751010 22939629 26344197 28514442 31536960 details
SYK_HUMANOFD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
SYK_HUMANCELF1_HUMANIntAct31413325 details
SYK_HUMANSH3R2_HUMANBioGRID24130170 details
SYK_HUMANABCE1_HUMANBioGRID25659154 details
SYK_HUMANCA131_HUMANBioGRID26472760 details
SYK_HUMANGCR_HUMANBioGRID28611094 details
SYK_HUMANANDR_HUMANBioGRID28611094 details