Entity Details

Primary name PRF1
Entity type gene
Source Source Link

Details

PrimaryID5551
RefseqGeneNG_009615
SymbolPRF1
Nameperforin 1
Chromosome10
Location10q22.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-01-14
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsPERF_HUMAN

GO terms

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GOName
GO:0001771 immunological synapse formation
GO:0001913 T cell mediated cytotoxicity
GO:0002357 defense response to tumor cell
GO:0002418 immune response to tumor cell
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006968 cellular defense response
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019835 cytolysis
GO:0022829 wide pore channel activity
GO:0031904 endosome lumen
GO:0042802 identical protein binding
GO:0044194 cytolytic granule
GO:0051260 protein homooligomerization
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of other organism

Diseases

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Interactions

10 interactions

InteractorPartnerSourcesPublicationsLink
PRF1DDX24HPRD, IntAct16169070 details
PRF1PRF1BioGRID, DIP, InnateDB21037563 21685908 details
PRF1KRT31BioGRID, IntAct25416956 32296183 details
PRF1CYSRT1BioGRID, IntAct32296183 details
PRF1NOTCH2NLABioGRID, IntAct32296183 details
PRF1CALRBioGRID, HPRD9671507 details
PRF1TRIM54BioGRID17360532 details
PRF1SRGNIntAct11911826 details
PRF1GZMBHPRD, IntAct11911826 8770355 details
PRF1FBXO6BioGRID22268729 details